Neural substrate for vergence eye movements

• Project/Area Number: 22500355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SUGIUCHI Yuriko 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30251523)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 眼球運動 / 運動制御 / 外眼筋 / 輻輳 / 核上性ニューロン / 上丘 / 開散 / 核上性細胞

Research Abstract

This study was aimed at analyzing the neural substrate for vergence eye movements. The results suggested that the pathway from the rostral part of the superior colliculus to medial rectus motoneurons via the area dorsal to the oculomotor nucleiand the adjacent reticular formation is involved in vergence eye movements.

Research Products

• [Journal Article] Input-output organization of inhibitory neurons in the interstitial nucleus of Cajalprojecting to the contralateral trochlear and oculomotor nucleus (2013)
  • Author(s): Sugiuchi Y, Takahashi M, and Shinoda Y
  • Journal Title: Journal of Neurophysiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] 前庭脊髄路 (2012)
  • Author(s): 杉内友理子
  • Journal Title: ClinicalNeuroscience, めまい Vertigo,Dizziness orElse? Volume: Vol.30 (1) Pages: 37-42
  • NAID: 10009387415
• [Journal Article] 眼球運動系の抑制ニューロ ン,抑制性シナプスの基礎と臨床 (2012)
  • Author(s): 杉内友理子
  • Journal Title: Clinical Neuroscience Volume: Vol.30 (12) Pages: 1363-1368
• [Journal Article] 前庭脊髄路 (2012)
  • Author(s): 杉内友理子
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 37-42
  • NAID: 10009387415
• [Journal Article] 眼球運動系の抑制ニューロン (2012)
  • Author(s): 杉内友理子
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 1363-1368
• [Journal Article] Input-output organization of inhibitory burst neurons in the interstitial nucleus of Cajal (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, and Shinoda Y
  • Journal Title: Annals of the New York Academy of Sciences Suppl 1233 Pages: 133-151
  • Peer Reviewed
• [Journal Article] Commissural inhibition between bilateral superior colliculi for saccades and bilateral vestibular nuclei for vestibulo-ocular reflex (VOR) (2011)
  • Author(s): Takahashi M, Sugiuchi Y, and Shinoda Y
  • Journal Title: Annals of the New York Academyof Sciences Suppl 1233 Pages: 152-174
  • Peer Reviewed
• [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades (2011)
  • Author(s): Shinoda Y, Sugiuchi Y, Takahashi M, and Izawa Y
  • Journal Title: Annals of the New York Academy of Sciences 1233 Pages: 100-106
  • Peer Reviewed
• [Journal Article] 急速眼球運動の神経機構-前庭系との接点- (2011)
  • Author(s): 杉内友理子,高橋真有
  • Journal Title: Equilibrium Research 70 Pages: 89-94
  • NAID: 10029512309
  • Peer Reviewed
• [Journal Article] Neural substrate for suppression of omnipause neurons at the onset of saccades (2011)
  • Author(s): Shinoda, Y., Sugiuchi, Y., Takahashi, M., Izawa, Y.
  • Journal Title: Ann.N.Y.Acad.Sci. Volume: 1233 Issue: 1 Pages: 100-106
  • DOI: 10.1111/j.1749-6632.2011.06171.x
  • Peer Reviewed
• [Journal Article] Input-output organization of inhibitory burst neurons in the interstitial nucleus of Cajal (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y
  • Journal Title: Annals of the New York Academy of Sciences Supplement Volume: 1233 Pages: 133-151
  • Peer Reviewed
• [Journal Article] Commissural inhibition between bilateral superior colliculi for saccades and bilateral vestibular nuclei for vestibulo-ocular reflex (VOR) (2011)
  • Author(s): Takahashi M, Sugiuchi Y, Shinoda Y
  • Journal Title: Annals of the New York Academy of Sciences Supplement Volume: 1233 Pages: 152-174
  • Peer Reviewed
• [Journal Article] 急速眼球運動の神経機構-前庭系との接点- (2011)
  • Author(s): 杉内友理子, 高橋真有
  • Journal Title: Equilibrium Research Volume: 70 Pages: 89-94
  • NAID: 10029512309
  • Peer Reviewed
• [Journal Article] 急速眼球運動の神経機構-前庭系との接点- (2011)
  • Author(s): 杉内友理子, 高橋真有
  • Journal Title: Equilibrium Res Volume: Vol.70 in press
  • NAID: 10029512309
  • Peer Reviewed
• [Journal Article] Topographic organization of excitatory and inhibitory commissural connections in the superior colliculi and their functional roles in saccade generation (2010)
  • Author(s): Takahashi M, Sugiuchi Y. and Shinoda Y
  • Journal Title: Journal of Neurophysiology Volume: 104 Pages: 3146-3167
  • Peer Reviewed
• [Journal Article] 上丘における機能局在について (2010)
  • Author(s): 杉内友理子,高橋真有
  • Journal Title: Equilibrium Research 69 Pages: 58-63
  • NAID: 10026088717
  • Peer Reviewed
• [Journal Article] Topographic organization of excitatory and Inhibitory commissural connections in the superior colliculi and their functional roles in saccade generation. (2010)
  • Author(s): M.Takahashi, Y.Sugiuchi, Y.Shinoda
  • Journal Title: J Neurophysiol Volume: Vol.104 Pages: 3146-3167
  • Peer Reviewed
• [Journal Article] 上丘における機能局在について (2010)
  • Author(s): 杉内友理子, 高橋真有
  • Journal Title: Equilibrium Res Volume: Vol.69 Pages: 58-63
  • NAID: 10026088717
  • Peer Reviewed
• [Presentation] 垂直性サッケード生成に関与する抑制性核上性ニューロン (2012)
  • Author(s): 杉内友理子、高橋真有、伊澤佳子、篠田義一
  • Organizer: 第71回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 東京
• [Presentation] サッケード系の座標軸とListingの法則の中枢性神経基盤 (2012)
  • Author(s): 高橋真有、杉内友理子、篠田義一
  • Organizer: 第71回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 東京
• [Presentation] 上丘間交連性結合の機能的役割と前庭動眼反射系およびListingの法則との関わりFunctional roles of commissural inhibition and excitation between the superior colliculi for control of vertical saccades in relation to the VOR and Listing's law (2012)
  • Author(s): 高橋真有、杉内友理子、篠田義一
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Functional roles of commissural inhibition and excitation between the superiorcolliculi for control of saccades in relationto Listings law and the VOR (2012)
  • Author(s): Takahashi M, Shinoda Y. and Sugiuchi Y
  • Organizer: NeuralControl of Movement 22nd Annual Meeting
  • Place of Presentation: Venice, Italy
• [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of saccades in relation to Listing s law and the VOR. (2012)
  • Author(s): Takahashi M,Shinoda Y,Sugiuchi Y
  • Organizer: Neural Control of Movement 22nd Annual Meeting
  • Place of Presentation: Venice, Italy
• [Presentation] Functional roles of commissural inhibition and excitation between the superior colliculi for control of vertical saccades in relation to the VOR and Listing's law. (2012)
  • Author(s): Takahashi M,Shinoda Y,Sugiuchi Y
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 垂直性サッケード生成における上丘交連性結合の機能的役割と前庭動眼反射(VOR)系との相似 (2011)
  • Author(s): 高橋真有、杉内友理子、篠田義一
  • Organizer: 第70回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 千葉
• [Presentation] 垂直性サッケードと水平性サッケード生成に関わる神経回路の相同性 (2011)
  • Author(s): 杉内友理子、高橋真有、伊澤佳子、篠田義一
  • Organizer: 第70回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 千葉
• [Presentation] Neural circuits for vertical saccades and their similarity to the vestibulooculomotor system (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, and Shinoda Y
  • Place of Presentation: University of New England, Biddeford, Maine, USA.
• [Presentation] Functional roles of tectal commissural inhibition and excitation for generation of horizontal and vertical saccades (2011)
  • Author(s): Takahashi M, Sugiuchi Y, and Shinoda Y
  • Place of Presentation: University of New England, Biddeford, Maine, USA.
• [Presentation] Input-output organization of excitatory and inhibitory premotor neurons in the vertical saccade system (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, and Shinoda Y
  • Organizer: Basic and Clinical Ocular Motor and Vestibular Research: A Tribute to John Leigh
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Commissural inhibition between bilateral superior colliculi for saccades and bilateral vestibular nuclei for VOR (2011)
  • Author(s): Takahashi M, Sugiuchi Y, and Shinoda Y
  • Organizer: Basic and Clinical Ocular Motor and Vestibular Research: A Tribute to John Leigh
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Input-output organization of excitatory and inhibitory premotor neurons in the vertical saccade system (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y
  • Organizer: Basic and Clinical Ocular Motor and Vestibular Research : A Tribute to John Leigh
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Commissural inhibition between bilateral superior colliculi for saccades and bilateral vestibular nuclei for VOR (2011)
  • Author(s): Takahashi M, Sugiuchi Y, Shinoda Y
  • Organizer: Basic and Clinical Ocular Motor and Vestibular Research : A Tribute to John Leigh
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] Neural circuits for vertical saccades and their similarity to the vestibulooculomotor system (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Maine, U.S.A.
• [Presentation] Functional roles of tectal commissural inhibition and excitation for generation of horizontal and vertical saccades (2011)
  • Author(s): Takahashi M, Sugiuchi Y, Shinoda Y
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Maine, U.S.A.
• [Presentation] 垂直性サッケード生成における上丘交連性結合の機能的役割と前庭動眼反射(.VOR)系との相似 (2011)
  • Author(s): 高橋真有、杉内友理子、伊澤佳子、篠田義一
  • Organizer: 第70回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 千葉
• [Presentation] Input-output organization of excitatory and inhibitory premotor neurons in the vertical saccade system. (2011)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y.
  • Organizer: Symposium on 'Basic and Clinical Ocular Motor and Vestibular Research : in honor of Prof.John Leigh'
  • Place of Presentation: Argentinian Catholic University(Buenos Aires,Argentina)
• [Presentation] Commissural inhibition between bilateral superior colliculi for saccades and bilateral vestibular nuclei for VOR. (2011)
  • Author(s): Takahashi, M., Sugiuchi, Y., Shinoda, Y.
  • Organizer: Symposium on 'Basic and Clinical Ocular Motor and Vestibular Research : in honor of Prof.John Leigh'
  • Place of Presentation: Argentinian Catholic University(Buenos Aires,Argentina)
• [Presentation] 左右上丘間の交連性結合の形態と垂直系および水平系サッケード生成における機能的役割について..Topographic organization of commissural connections between the two superior colliculi and their functional rolesfor generating horizontal and vertical saccades (2010)
  • Author(s): 高橋真有,杉内友理子,篠田義一
  • Organizer: 第33回日本神経科学大会(第53回日本神経化学会大会および第20回日本神経回路学会大会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-24
• [Presentation] 「急速眼球運動の神経機構-前庭系とのかかわり-」シンポジウム1「前庭系の最先端研究-分子生物学からシステムニューロサイエンスまで」 (2010)
  • Author(s): 杉内友理子
  • Organizer: 第69回日本めまい平衡医学会総会・学術講演会
  • Place of Presentation: 京都
• [Presentation] 垂直性サッケード生成に関わる左右上丘間の興奮性・抑制性交連性細胞の同定 (2010)
  • Author(s): 高橋真有、杉内友理子、篠田義一
  • Organizer: 第69回日本めまい平衡医学会総会
  • Place of Presentation: 京都
• [Presentation] Neural circuit for generation of vertical saccades ?Input-output organization of neurons in the interstitial nucleus of Cajal? (2010)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y
  • Organizer: Advances in Oculomotor and Vestibular Systems, A Tribute to Professor Edward Keller, A Satellite Meeting of the Society for the Neural Control of Movement 20th Annual Meeting
  • Place of Presentation: Naples, Florida, U.S.A.
• [Presentation] Neural circuit for generation of vertical saccades -Input-output organization of neurons in the interstitial nucleus of Cajal- (2010)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y.
  • Organizer: Symposium on "Advances in Oculomotor and VestibularSystems" in honor of Prof.Edward Keller
  • Place of Presentation: Naples(Florida,USA)
• [Presentation] Neural Circuit for Generation of Vertical Saccades -Role of Commissural Excitation and Inhibition in the Superior Colliculi- (2010)
  • Author(s): Takahashi, M., Sugiuchi, Y., Shinoda, Y.
  • Organizer: Symposium on "Advances in Oculomotor and Vestibular Systems" in honor of Prof.Edward Keller
  • Place of Presentation: Naples(Florida,USA)
• [Presentation] 左右上丘間の交連性結合の形態と垂直系および水平系サッケード生成における機能的役割について (2010)
  • Author(s): 高橋真有, 杉内友理子, 篠田義一
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 国際会議場(神戸)
• [Presentation] 急速眼球運動の神経機構-前庭系とのかかわり- (2010)
  • Author(s): 杉内友理子
  • Organizer: 第69回日本めまい平衡医学会総会
  • Place of Presentation: 国際会議場(京都)
• [Presentation] 垂直性サッケード生成に関わる左右上丘間の興奮性・抑制性交連性細胞の同定 (2010)
  • Author(s): 高橋真有、杉内友理子、篠田義一
  • Organizer: 第69回日本めまい平衡医学会総会
  • Place of Presentation: 国際会議場(京都)
• [Remarks] 動眼神経核
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 平衡感覚
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 前庭神経核
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 前庭脊髄路
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 半規管と耳石器
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 動眼神経核
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 平衡感覚
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 前庭神経核
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 前庭脊髄路
  • URL: http://bsd.neuroinf.jp/wiki/
• [Remarks] 半規管と耳石器
  • URL: http://bsd.neuroinf.jp/wiki/