Analysis of molecular integration by basal membrane in synapse formation and maintenance.

• Project/Area Number: 22500356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kyoto University
• Principal Investigator: HOSOKAWA Hiroshi 京都大学, 大学院・情報学研究科, 講師 (90359779)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ニューロン / シナプス / 神経回路 / 基底膜 / 神経科学 / 精神疾患 / スカフォールド / 行動 / 情動 / 集積

Research Abstract

A physiological roles of molecular integration in synapse was studied by analysis of MAGI1 which indirectly binds to basal membrane. Biochemical and histochemical analysis revealed that MAGI1 was expressed in neuronal cells and localized on post synapse in brain. MAGI1 knockout mice showed abnormal anxiety -like and attention behaviour. In conlusion, molecular integration was required for normal synapse function and behavior.

Research Products

• [Journal Article] Intragastric administration of allyl isothiocyanate reduces hyperglycemia in intraperitoneal glucose tolerance test (IPGTT) by enhancing blood glucose consumption in mice. (2013)
  • Author(s): Mori N, Kurata M, Yamazaki H, Hosokawa H, Nadamoto T, Inoue K, Fushiki T
  • Journal Title: J Nutr Sci Vitaminol Volume: 59 Pages: 56-63
  • NAID: 130003368149
  • Peer Reviewed
• [Journal Article] The distribution of transient receptor potential melastatin-8in the rat soft palate, epiglottis, and pharynx. (2013)
  • Author(s): Sato T, Fujita M, Kano M, Hosokawa H, Kondo T, Suzuki T, Kasahara E, Shoji N, Sasano T, Ichikawa H.
  • Journal Title: Cell Mol Neurobiol Volume: 33 Issue: 2 Pages: 161-5
  • DOI: 10.1007/s10571-012-9888-1
  • Peer Reviewed
• [Journal Article] Intragastric Administration of Allyl Isothiocyanate Reduces Hyperglycemia in Intraperitoneal Glucose Tolerance Test (IPGTT) by Enhancing Blood Glucose Consumption in Mice. (2013)
  • Author(s): Mori N, Kurata M, Yamazaki H, Hosokawa H, Nadamoto T, Inoue K, Fushiki T. (MoriN)
  • Journal Title: J Nutr Sci Vitaminol (Tokyo). Volume: 59 Pages: 56-63
  • NAID: 130003368149
  • Peer Reviewed
• [Journal Article] Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice. (2011)
  • Author(s): Mori N, Kawabata F, Matsumura S, Hosokawa H, Kobayashi S, Inoue K, Fushiki T
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 300 Pages: 494-505
• [Journal Article] Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling. (2011)
  • Author(s): Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S.
  • Journal Title: PLoS One Volume: 6
  • NAID: 120002970854