| Project/Area Number |
22500361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Takahiro 久留米大学, 分子生命科学研究所, 准教授 (50368883)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | グレリン / 自律神経機能 / 血圧調節機構 / グレリン遺伝子欠損マウス / 日内リズム / テレメトリー自動計測システム / 血圧調節 / 体温調節 |
|---|
| Research Abstract |
Ghrelin, the only circulating orexigenic hormone, increases appetite and food intake by stimulating the hypothalamic arcuate nucleus through vagal afferent neurons. Although ghrelin has been reported to play a crucial role in the regulation of the autonomic nervous system, its precise mechanisms or physiological relevance is not completely elucidated yet. Here we explored the existence of an abnormal circadian rhythm of blood pressure (BP), heart rate (HR) and body temperature (BT) in ghrelin knockout (ghrl-/-) mice using telemetric automatic analysis system. It has been demonstrated that ghrelin, secreted from stomach, controls the tone balance of BP, HR, and BT through the regulation of central autonomic nervous system. Thus, ghrelin is a hormone to maintain the homeostasis of the autonomic nervous system as well as anaccelerating factor of food intake.
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