Properties of intercellular signal transmission determined by the fine structure of synapses
| Project/Area Number |
22500362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
MATSUI Ko 生理学研究所, 大脳皮質機能研究系, 准教授 (20435530)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMASAWA Naomi 生理学研究所, 大脳皮質機能研究系, 特任助教 (50455218)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳・神経 / 神経科学 / 生理学 / シナプス / 伝達物質 / シミュレーション / 細胞形態学 / 微細形態学 |
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| Research Abstract |
There exists a gap between cells and neurons communicate with each other by crossing signals through this gap. In this study, we estimated the amount of transmitter molecules packed within a synaptic vesicle and the speed of diffusion of these molecules in the extracellular space. Using these estimates, we evaluated the amount of transmitter that would spillover from a synapse and the effect of these transmitters on the neighboring synapses. The visual relay synapse has specific structure that promotes such intersynaptic interactions, and we found that filtering of visual information is accomplished through these interactions.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012
Author(s)
K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
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Journal Title
Cell Reports
Volume: 2
Issue: 2
Pages: 397-406
DOI
Related Report
Peer Reviewed
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