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Properties of intercellular signal transmission determined by the fine structure of synapses

Research Project

Project/Area Number 22500362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

MATSUI Ko  生理学研究所, 大脳皮質機能研究系, 准教授 (20435530)

Co-Investigator(Renkei-kenkyūsha) KAMASAWA Naomi  生理学研究所, 大脳皮質機能研究系, 特任助教 (50455218)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳・神経 / 神経科学 / 生理学 / シナプス / 伝達物質 / シミュレーション / 細胞形態学 / 微細形態学
Research Abstract

There exists a gap between cells and neurons communicate with each other by crossing signals through this gap. In this study, we estimated the amount of transmitter molecules packed within a synaptic vesicle and the speed of diffusion of these molecules in the extracellular space. Using these estimates, we evaluated the amount of transmitter that would spillover from a synapse and the effect of these transmitters on the neighboring synapses. The visual relay synapse has specific structure that promotes such intersynaptic interactions, and we found that filtering of visual information is accomplished through these interactions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held2013

    • Author(s)
      Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R Matsui K
    • Journal Title

      Journal of Physiology

      Volume: 591 Issue: 1 Pages: 219-239

    • DOI

      10.1113/jphysiol.2012.241398

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative localization of Ca(v)2.1 (P/Q-type) voltage-dependent calcium channels in Purkinje cells: somatodendritic gradient and distinct somatic coclustering with calcium-activated potassium channels2013

    • Author(s)
      Indriati DW, Kamasawa N, Matsui K, Meredith AL, Watanabe M, Shigemoto R
    • Journal Title

      Journal of Neuroscience

      Volume: 33 Issue: 8 Pages: 3668-3678

    • DOI

      10.1523/jneurosci.2921-12.2013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation2012

    • Author(s)
      Sasaki T, Beppu K, Tanaka KF, Fukazawa Y, Shigemoto R, Matsui K
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Pages: 20720-20725

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012

    • Author(s)
      K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
    • Journal Title

      Cell Reports

      Volume: 2 Issue: 2 Pages: 397-406

    • DOI

      10.1016/j.celrep.2012.06.011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity2012

    • Author(s)
      Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio DA
    • Journal Title

      Neuron

      Volume: 73 Issue: 6 Pages: 1159-1172

    • DOI

      10.1016/j.neuron.2012.01.027

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kv4.2 potassium channels segregate to extrasynaptic domains in amygdala intercalated neurons and influence intrasynaptic NMDA receptor NR2B subunit expression2012

    • Author(s)
      Kaufmann WA, Matsui K, Jeromin A, Nerbonne J, Ferraguti F
    • Journal Title

      Brain Structure and Function

      Volume: - Issue: 5 Pages: 1-18

    • DOI

      10.1007/s00429-012-0450-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative regional and ultrastructural localization of the Cav2.3 subunit of R-type calcium channels in mouse brain2012

    • Author(s)
      Parajuli L, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 39 Pages: 13555-13567

    • DOI

      10.1523/jneurosci.1142-12.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABAA receptors in cortical pyramidal cells2012

    • Author(s)
      Sumegi M, Fukazawa Y, Matsui K, Lorincz A, Eyre MD, Nusser Z, Shigemoto R
    • Journal Title

      Journal of Physiology

      Volume: 590 Issue: 7 Pages: 1517-1534

    • DOI

      10.1113/jphysiol.2012.227538

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying signal filtering at a multi-synapse contact2012

    • Author(s)
      Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R
    • Journal Title

      Journal of Neuroscience

      Volume: 32 Issue: 7 Pages: 2357-2376

    • DOI

      10.1523/jneurosci.5243-11.2012

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of an optogenetic byway for perturbing neuronal activity via glialphotostimulation.2012

    • Author(s)
      T. Sasaki. K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui
    • Journal Title

      Proceedings National Academy of Sciences of the USA

      Volume: 109 Issue: 50 Pages: 20720-20725

    • DOI

      10.1073/pnas.1213458109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生きたままのマウスの脳細胞を光で操作する技術の開発2012

    • Author(s)
      松井 広
    • Journal Title

      OplusE

      Volume: 396 Pages: 1085-1090

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 視床:単なる中継核ではない‐生理学的基礎2012

    • Author(s)
      松井 広
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 24-26

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Presynaptic, postsynaptic, and morphological determinants of signal transmission at the retinogeniculate synapse2010

    • Author(s)
      Ko Matsui, Timotheus Budisantoso, Naomi Kamasawa, Yugo Fukazawa, Ryuichi Shigemoto
    • Journal Title

      Neuroscience Research

      Volume: 68S

    • Related Report
      2010 Annual Research Report
  • [Presentation] Exploring the causal relationship between glial activity and mind2013

    • Author(s)
      松井 広
    • Organizer
      日本生理学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Exploring the causal relationship between glial activity and mind2013

    • Author(s)
      松井 広
    • Organizer
      日本生理学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] グリア細胞刺激による神経活動および個体行動の制御2013

    • Author(s)
      別府 薫
    • Organizer
      日本生理学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neuronal activity and behavior driven by astrocytes2012

    • Author(s)
      Ko Matsui
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Neuronal activity and behavior driven by astrocytes2012

    • Author(s)
      松井 広
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuronal activity and behavior driven by astrocytes2012

    • Author(s)
      松井 広
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Estimation of the concentration and the time course of glutamate in the synaptic cleft2012

    • Author(s)
      Timotheus Budisantoso
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] High resolution analysis of presynaptic protein distribution patterns with freeze‐fracture replica immunolabeling.2012

    • Author(s)
      Harada Harumi
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 定量的分子局在解析と計算論的手法によるシナプス構造-機能連関の解析2011

    • Author(s)
      深澤有吾、松井広
    • Organizer
      日本顕微鏡学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網膜‐外側膝状体シナプスにおける信号伝達特性を規定する要因の解明2010

    • Author(s)
      松井 広、Timotheus Budisantoso、釜澤 尚美、深澤 有吾、重本 隆一
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 網膜-外側膝状体シナプスにおける信号伝達特性を規定する要因の解明2010

    • Author(s)
      松井広、Timotheus Budisantoso、釜澤尚美、深澤有吾、重本隆一
    • Organizer
      日本神経科学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] シナプス微細構造が定める信号伝達特性の解明2010

    • Author(s)
      松井広
    • Organizer
      生理学研究所研究会「シナプス可塑性の動作原理」
    • Place of Presentation
      生理学研究所(愛知)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Presynaptic, postsynaptic, and morphological determinants of signal transmission at a central synapse2010

    • Author(s)
      Ko Matsui
    • Organizer
      NIPS International Workshop
    • Place of Presentation
      岡崎コンファレンスセンター(愛知)
    • Year and Date
      2010-06-02
    • Related Report
      2010 Annual Research Report
  • [Book] オプトジェネティクス―光工学と遺伝学による行動抑制技術の最前線2013

    • Author(s)
      神取 秀樹
    • Total Pages
      288
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2012 Annual Research Report
  • [Remarks] プレスリリース「目から入ってくる溢れるような視覚情報を "くっきり"させて脳に伝える仕組みの一端を解明」

    • URL

      http://www.nips.ac.jp/contents/release/entry/2012/02/post-202.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 目から入ってくる溢れるような視覚情報を "くっきり"させて脳に伝える仕組みの一端を解明

    • URL

      http://www.nips.ac.jp/contents/release/entry/2012/02/post-202.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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