Investigation of the role of astrocytic Ca2+ signaling in higher brain functions
| Project/Area Number |
22500369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TANAKA Mika 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 専門職研究員 (70311347)
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| Research Collaborator |
ALEXEY Semyanov 独立行政法人理化学研究所, シナプス外シグナル伝達研究ユニット, ユニットリーダー
PEI-YU Shih 独立行政法人理化学研究所, セミアノフリサーチユニット, リサーチアソシエイト
吉田 崇将 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, 研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アストロサイト / カルシウムイオン / トリパータイトシナプス / カルシウム / シナプス / IP3 / 海馬 / LTP |
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| Research Abstract |
To examine the role of astrocytic Ca^<2+> signaling in higher brain functions, we generated an inducible transgenic mouse model in which astrocytic Ca^<2+> signaling is attenuated. Attenuated Ca2+ activity correlated with reduced astrocytic coverage of asymmetric synapses in the hippocampal CA1 region in these animals. The decreased astrocytic ‘protection’ of the synapses facilitated glutamate ‘spillover’, and these mice exhibited behavioral impairments in which hippocampal circuits are involved.
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Report
(4 results)
Research Products
(8 results)
