| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
In the present study, we used rat brain slice preparations to investigate the sleep/wake-state dependent synaptic plasticity in inhibitory synapses in the neocortex. Pharmacological analyses, dual whole-cell recordings and non-steady state noise analyses revealed the molecular and cellular mechanisms of the state-dependent plasticity induced in inhibitory synapses at the apical dendrite and/or soma of cortical pyramidal neurons.
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