| Project/Area Number |
22500371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | Niigata University (2011-2012)
National Center of Neurology and Psychiatry (2010) |
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Principal Investigator |
NAKAHARA Kiyoshi 新潟大学, 研究推進機構・超域学術院, 准教授 (50372363)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA Takashi 国立精神・神経医療研究センター, 神経研究所, 室長 (00326828)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルスベクター / 光脳科学 / 皮質脳波 / 霊長類 / 長期記憶 / 内側側頭葉 / 記憶システム / 視覚野 / 線条体 / 遺伝子導入 / 連合記憶 |
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| Research Abstract |
To explore the spatio-temporal dynamics of cortical activities associated with long-term memory retrieval, we aimed to combine optogenetic methods and multi-channel electrocorticogram (ECoG) recordings from the inferior and medial temporal cortices in macaque monkeys. In the first part of the project, we optogenetically stimulated the rat V1 at various stimulus frequencies, and performed spatiotemporal analysis of evoked cortical activity using a micro-ECoG array. We revealed the spatio-temporal dynamics of ECoG responses induced by optogenetic methods. In the second part of the project, we conducted multi-channel ECoG recordings from the medial temporal cortices, in two macaque monkeys while they performed a visual pair-association task. Time-frequency analyses of the ECoG responses suggested that the neural oscillation in the medial temporal lobe are involved in mechanisms of memory retrieval.
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