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Role of positive emotion on stress responses in adolescent rats

Research Project

Project/Area Number 22500378
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional social brain science
Research InstitutionFoundation for Advancement of International Science

Principal Investigator

HORI Miyo  公益財団法人国際科学振興財団, バイオ研究所, 専任研究員 (90399329)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Kazuo  (公財)国際科学振興財団, バイオ研究所, 所長 (70110517)
SAKAMOTO Shigeko  (公財)国際科学振興財団, バイオ研究所, 専任研究員 (60419869)
OHNISHI Eriko  (公財)国際科学振興財団, バイオ研究所, 専任研究員 (90396284)
OHNISHI Junji  東京家政大学, 東京家政大学, 准教授 (40261276)
ICHITANI Yukio  筑波大学, 人間系 (80176289)
YAMADA Kazuo  筑波大学, 人間系 (30282312)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords幼若期 / 隔離ストレス / 快情動 / Tickling / 情動 / ストレス / 恐怖条件づけ / モリス水迷路 / ドパミン / 遺伝子発現 / Ticling
Research Abstract

In order to demonstrate that a positive affective state, such as play during adolescence, contributes to reverse the changes caused by isolation stress, we analyzed the effects of tickling through behavioral and biochemical indices in post-weaning isolated rats. Tickling stimulation, resembles the rough-and-tumble play behavior in rats, triggers the dopamine release in the nucleus accumbens. Additionally, the tickling could modulate fear-related behavior and sympatho-adrenal response, and recovered the behavioral changes, that were caused by isolated rearing. In conclusion, positive emotion alters directly and/or indirectly neuronal circuitry and behaviors through the play in adolescence.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Products Report
  • Research Products

    (29 results)

All 2013 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (20 results) (of which Invited: 4 results) Remarks (2 results)

  • [Journal Article] Ticklingは幼若期のラットの情動応答に作用する2013

    • Author(s)
      堀美代
    • Journal Title

      日本生理学雑誌

    • URL

      http://phvsiologv.jp/exec/nisseishi/

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tickling increases dopamine release in the nucleus accumbens and 50 kHz ultrasonic vocalizations in adolescent rats2013

    • Author(s)
      Hori M, Shimoju R, Tokunaga R, Ohkubo M, Miyabe S, Ohnishi J, Murakami K, Kurosawa M.
    • Journal Title

      Neuroreport

      Volume: 24(5) Issue: 5 Pages: 241-245

    • DOI

      10.1097/wnr.0b013e32835edbfa

    • Related Report
      2012 Annual Research Report 2012 Final Research Report Products Report
    • Peer Reviewed
  • [Journal Article] Effects of repeated tickling on conditioned fear and hormonal responses in socially isolated rats2013

    • Author(s)
      Hori M, Yamada K, Ohnishi J, Sakamoto S, Takimoto-Ohnishi E, Miyabe S, Murakami K, Ichitani Y
    • Journal Title

      Neurosci Lett

      Volume: 536 Pages: 85-89

    • DOI

      10.1016/j.neulet.2012.12.054

    • Related Report
      2012 Annual Research Report 2012 Final Research Report Products Report
    • Peer Reviewed
  • [Journal Article] Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat2013

    • Author(s)
      Yamamuro T, Hori M, Nakagawa Y, Hayashi T, Sakamoto S, Ohnishi J, Takeuchi S, Mihara Y, Shiga T, Murakami K, Urayama O
    • Journal Title

      Behav Brain Res

      Volume: 236(1) Issue: 1 Pages: 236-243

    • DOI

      10.1016/j.bbr.2012.09.001

    • Related Report
      2012 Final Research Report Products Report
    • Peer Reviewed
  • [Journal Article] Ticklingは幼若期のラットの情動応答に作用する2013

    • Author(s)
      堀 美代
    • Journal Title

      日本生理学雑誌

    • Related Report
      Products Report
  • [Journal Article] 社会隔離飼育された幼若ラットの恐怖条件づけに及ぼすticklingの効果2011

    • Author(s)
      堀美代・山田一夫・大西淳之・坂本成子・村上和雄・一谷幸男
    • Journal Title

      動物心理学研究

      Volume: 61巻2号 Pages: 236-236

    • Related Report
      2012 Final Research Report Products Report
  • [Journal Article] 社会隔離飼育された幼若ラットの恐怖条件づけに及ぼすticklingの効果2011

    • Author(s)
      堀美代
    • Journal Title

      動物心理学研究

      Volume: 61巻2号 Pages: 236-236

    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular insights into mind-body medicine : Effect of "laughter" on gene expression.2013

    • Author(s)
      Ohnishi Junji
    • Organizer
      4th World Gene Convention-2013
    • Place of Presentation
      Hainan International Convention & Exhibition Center(中国・海南)
    • Year and Date
      2013-11-13 – 2013-11-16
    • Related Report
      Products Report
  • [Presentation] Molecular insights into mind-body medicine : Effect of "laughter" on gene expression.2013

    • Author(s)
      Takimoto-Ohnishi Eriko
    • Organizer
      3rd Annual World ongress of Molecular Medicine-2013,
    • Place of Presentation
      Hainan International Convention & Exhibition Center(中国・海南)
    • Year and Date
      2013-11-13 – 2013-11-16
    • Related Report
      Products Report
  • [Presentation] Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats.2013

    • Author(s)
      Hori Miyo
    • Organizer
      Society for Neuroscience Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center(米国・カルフォルニア)
    • Year and Date
      2013-11-09 – 2013-11-13
    • Related Report
      Products Report
  • [Presentation] 側坐核のドパミンの分泌及ぼすticklingの効果2013

    • Author(s)
      堀 美代
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Year and Date
      2013-09-14 – 2013-09-16
    • Related Report
      Products Report
  • [Presentation] 隔離飼育ラットにおける快情動刺激(Tickling)の効果2013

    • Author(s)
      堀美代
    • Organizer
      第45回筑波実験動物研究会講演会
    • Place of Presentation
      文部科学省研究交流センター(招待講演)
    • Year and Date
      2013-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 隔離飼育ラットにおける快情動刺激(Tickling)の効果2013

    • Author(s)
      堀 美代
    • Organizer
      第45回筑波実験動物研究会講演会
    • Place of Presentation
      文部科学省研究交流センター(茨城県つくば市)
    • Year and Date
      2013-06-07
    • Related Report
      Products Report
    • Invited
  • [Presentation] Tickling alters emotional responses in adolescent rats.2013

    • Author(s)
      Hori Miyo
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2013-03-27 – 2013-03-29
    • Related Report
      Products Report
    • Invited
  • [Presentation] Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats2013

    • Author(s)
      Hori M, et al.
    • Organizer
      Society for Neuroscience Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular insights into mind-body medicine: Effect of "laughter" on gene expression2013

    • Author(s)
      Ohnishi J et al.
    • Organizer
      4th World Gene Convention-2013
    • Place of Presentation
      Hainan International Convention & Exhibition Center
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular insights into mind-body medicine: Effect of "laughter" on gene expression2013

    • Author(s)
      Takimoto-Ohnishi E et al.
    • Organizer
      3rd Annual World ongress of Molecular Medicine-2013
    • Place of Presentation
      Hainan International Convention & Exhibition Center
    • Related Report
      2012 Final Research Report
  • [Presentation] 側坐核のドパミンの分泌及ぼすticklingの効果2013

    • Author(s)
      堀美代ら
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      筑波大学
    • Related Report
      2012 Final Research Report
  • [Presentation] Tickling alters emotional responses in adolescent rats2013

    • Author(s)
      Hori M.
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(招待講演)
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of tickling on hormonal responses to restraint stress and conditioned fear in socially isolated rats2013

    • Author(s)
      Miyo HORI
    • Organizer
      Society for Neuroscience Neuroscience 2013
    • Place of Presentation
      USA California
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tickling刺激は側坐核のドパミンの分泌と50-kHz音声表出に作用する2013

    • Author(s)
      堀 美代
    • Organizer
      第73回日本動物心理学会大会
    • Place of Presentation
      日本 つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 隔離飼育ラットにおける 快情動刺激(Tickling)の効果2013

    • Author(s)
      堀 美代
    • Organizer
      第45回筑波実験動物研究会講演会
    • Place of Presentation
      日本 つくば市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tickling alters emotional responses in adolescent rats2013

    • Author(s)
      Miyo HORI
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      日本 東京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 社会隔離飼育された幼若ラットの恐怖条件づけに及ぼすticklingの効果2011

    • Author(s)
      堀美代
    • Organizer
      Animal2011
    • Place of Presentation
      慶応義塾大学三田キャンパス
    • Year and Date
      2011-09-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 社会隔離飼育された幼若ラットの恐怖条件づけに及ぼすticklingの効果2011

    • Author(s)
      堀 美代
    • Organizer
      Animal2011日本動物心理学会・日本動物行動学会・応用動物行動学会/日本家畜管理学会合同学会
    • Place of Presentation
      慶應義塾大学(東京都港区)
    • Year and Date
      2011-09-08 – 2011-09-11
    • Related Report
      Products Report
  • [Presentation] 社会隔離飼育された幼若ラットの恐怖条件づけに及ぼすticklingの効果2011

    • Author(s)
      堀美代ら
    • Organizer
      Animal2011日本動物心理学会・日本動物行動学会・応用動物行動学会/日本家畜管理学会合同学会
    • Place of Presentation
      慶應義塾大学
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会隔離ストレスに対する快情動に及ぼす効果の解析2010

    • Author(s)
      堀美代
    • Organizer
      人体科学会第20回大会
    • Place of Presentation
      倫理文化センター
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://mind-vene.com/

    • Related Report
      2012 Final Research Report
  • [Remarks] 心と遺伝子研究会

    • URL

      http://mind-gene.com/

    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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