Neuronal mechanisms for the postnatal development of prosocial behavior

• Project/Area Number: 22500379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fusional social brain science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YOKOYAMA Chihiro 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (90264754)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 陽電子断層撮影(PET) / コモンマーモセット / 社会的環境 / 社会行動 / セロトニン / 向社会行動 / 脳機能イメージング / 養育環境 / セロトニントランスポーター / 背内側前頭皮質 / 前帯状回 / 後帯状回 / 内側前頭前野

Research Abstract

We developed the tests for evaluating behavior traits constructing interpersonal relationship in non-human primate species, common marmosets, and examined the brain mechanisms underlying them. The positron emission tomography (PET) for in vivo brain imaging in common marmosets suggested the functional role of serotonin in the midline cortical structures as a part of the social and default mode networks.

Research Products

• [Journal Article] Evaluation of dopamine D_2/D_3 and serotonin 5-HT_2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography (2013)
  • Author(s): Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H
  • Journal Title: Psychopharmacol Volume: 225 Pages: 329-339
  • Peer Reviewed
• [Journal Article] Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography. (2013)
  • Author(s): Shunsuke Nakazawa
  • Journal Title: Psychopharmacology Volume: 225 Issue: 2 Pages: 329-339
  • DOI: 10.1007/s00213-012-2815-9
  • Peer Reviewed
• [Journal Article] The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey (2012)
  • Author(s): Asakawa T, Sugiyama K, Akamine S, Yokoyama C, Shukuri M, Mizuma H, Tsukada H, Onoe H, Namba H
  • Journal Title: Neurosci Res Volume: 74 Pages: 122-128
  • Peer Reviewed
• [Journal Article] Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets (2012)
  • Author(s): Yokoyama C, Kawasaki A, Hayashi T, Onoe H.
  • Journal Title: Cereb Cortex Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease (2012)
  • Author(s): Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N
  • Journal Title: J Neural Transm Volume: 119 Pages: 933-941
  • Peer Reviewed
• [Journal Article] The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey. (2012)
  • Author(s): Tetsuya Asakawa
  • Journal Title: Neuroscience Research Volume: 74 Issue: 2 Pages: 122-128
  • DOI: 10.1016/j.neures.2012.07.006
  • Peer Reviewed
• [Journal Article] Linkage between the midline cortical serotonergic system and social behavior traits: Positron emission tomography studies of common marmosets. (2012)
  • Author(s): Chihiro Yokoyama
  • Journal Title: Cerebral Cortex Volume: in press
  • Peer Reviewed
• [Journal Article] Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease. (2012)
  • Author(s): Kazunori Adachi
  • Journal Title: Journal of Neural Transmission Volume: 119 Issue: 8 Pages: 933-941
  • DOI: 10.1007/s00702-012-0768-0
  • Peer Reviewed
• [Journal Article] Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior (2011)
  • Author(s): Watanabe Y, Tsujimura A, Takao K, Nishi K, Ito Y, Yasuhara Y, Nakatomi Y, Yokoyama C, Fukui K, Miyakawa T, Tanaka M
  • Journal Title: Front Behav Neurosci Volume: 5 Pages: 50-50
  • Peer Reviewed
• [Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir (2011)
  • Author(s): Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
  • Journal Title: J Nucl Med Volume: 52 Pages: 950-957
  • Peer Reviewed
• [Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole (2011)
  • Author(s): Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
  • Journal Title: Neuroreport Volume: 22 Pages: 326-330
  • Peer Reviewed
• [Journal Article] Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys (2010)
  • Author(s): Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H
  • Journal Title: Synapse Volume: 64 Pages: 594-601
  • Peer Reviewed
• [Journal Article] Mapping of serotonin transporters by positron emission tomography with [(11)C]DASB in conscious common marmosets : comparison with rhesus monkeys. (2010)
  • Author(s): Yokoyama C
  • Journal Title: Synapse Volume: 64 Pages: 594-601
  • Peer Reviewed
• [Presentation] The midline cortical serotonergic system in social behavior traits: Positron emission tomography studies of common marmosets (2012)
  • Author(s): Yokoyama C, Kawasaki A, Hayashi K, Onoe H
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-12
• [Presentation] 早期養育環境がコモンマーモセットの社会行動へ及ぼす影響 (2012)
  • Author(s): 横山 ちひろ、川崎 章弘、武田 千穂、尾上 浩隆
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] コモンマーモセットにおける音声の個体識別と脳活動の相関 (2012)
  • Author(s): 加藤 真樹、横山 ちひろ、川崎 章弘、武田 千穂、小池 巧、尾上 浩隆、入來 篤史
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] Social behavior traits represented by serotonin function in midline cortical structures (2012)
  • Author(s): Yokoyama C, Kawasaki A, Hayashi K,Onoe H
  • Organizer: Frontiers in Biomedical Researches on Marmosets as a Primate Model
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-02-21
• [Presentation] Social behavior traits represented by serotonin function in midline cortical structures (2012)
  • Author(s): Chihiro Yokoyama
  • Organizer: Frontiers in Biomedical Researches on Marmosets as a Primate Model
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2012-02-21
• [Presentation] Social behavior and serotonin in the midline cortex: Positron emission tomography studies of common marmosets (2012)
  • Author(s): Yokoyama C
  • Organizer: 14th Conference of Peace through Mind Brain Science
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2012-02-14
• [Presentation] Social behavior and serotonin in the midline cortex : Positron emission tomography studies of common marmosets (2012)
  • Author(s): Chihiro Yokoyama
  • Organizer: 14th Mind Brain Science Symposium
  • Place of Presentation: ホテルクラウンパレス浜松(浜松市)(招待講演)
  • Year and Date: 2012-02-14
• [Presentation] Dopamine D2 receptor occupancies of olanzapine and novel antipsychotic lurasidone; study in conscious common marmosets using small-animal positron emission tomography (2011)
  • Author(s): Nakazawa S, Yokoyama C, Nishimura N, Kawasaki A, Kirai S, Doi H, Onoe H
  • Organizer: 41th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-13
• [Presentation] 他者との社会的関係性の個体差に関わる神経学的要因:コモンマーモセットを用いたPET研究 (2011)
  • Author(s): 横山ちひろ、川崎章弘、林拓也、尾上浩隆
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] マーモセットにおけるボイス刺激を用いたGo-Nogo課題 (2011)
  • Author(s): 彦坂和雄、難波文恵、横山ちひろ、尾上浩隆
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 他者との社会的関係性の個体差に係る神経学的要因:コモンマーモセットを用いたPET研究 (2011)
  • Author(s): 横山ちひろ
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-09-16
• [Presentation] マーモセットにおけるボイス刺激を用いたGo-Nogo課題 (2011)
  • Author(s): 彦坂和雄
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-09-16
• [Presentation] 脳内アロマテース活性とコモンマーモセットの社会行動特性との関連:11C-cetrozole を用いたPET研究 (2011)
  • Author(s): 横山ちひろ、川崎章弘、高橋佳代、細谷孝充、渡辺恭良、尾上浩隆
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-26
• [Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング -[11C]AZ10419369を用いたPET研究- (2011)
  • Author(s): 山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-26
• [Presentation] 無麻酔下コモンマーモセットPETを用いた抗精神病薬ルラシドンとオランザピンのドパミンD2受容体占有率の評価 (2011)
  • Author(s): 中澤俊介、西村直浩、横山ちひろ、川崎章弘、倉井佐知、土居久志、矢野恒夫、渡辺恭良、尾上浩隆
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-26
• [Presentation] 脳内アロマテース活性とコモンマーモセットの社会行動特性との関連:11C-cetrozoleを用いたPET研究 (2011)
  • Author(s): 横山ちひろ
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2011-05-26
• [Presentation] 無麻酔下コモンマーモセットPETを用いた抗精神病薬ルラシドンとオランザピンのドパミンD2受容体占有率の評価 (2011)
  • Author(s): 中澤俊介
  • Organizer: 第6回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2011-05-26
• [Presentation] Father's energetic cost during parental care period in cooperatively breeding common marmosets (2010)
  • Author(s): Tatsuta I, Kutsukake N, Yokoyama C, Onoe H, Hasegawa M
  • Organizer: 13th International Behavioral Ecology Congress
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-09-30
• [Presentation] Father's energetic cost during parental care period in cooperatively breeding common marmosets. (2010)
  • Author(s): Tatsuta I
  • Organizer: 13th International Behavioral Ecology Congress
  • Place of Presentation: Perth, Australia.
  • Year and Date: 2010-09-28
• [Presentation] Paternal changes in body weight during parental care period in cooperatively breeding common marmosets. (2010)
  • Author(s): Tatsuta I
  • Organizer: International Primatology Society XXIII Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-14
• [Presentation] Molecular brain imaging of personality traits in common marmosets (2010)
  • Author(s): Yokoyama C, Onoe H
  • Organizer: International Primatology Society XXIII Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-13
• [Presentation] Paternal changes in body weight during parental care period in cooperatively breeding common marmosets (2010)
  • Author(s): Tatsuta I, Kutsukake N, Kawasaki A, Yokoyama C, Onoe H, Hasegawa M
  • Organizer: International Primatology Society XXIII Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-13
• [Presentation] Molecular brain imaging of personality traits in common marmosets. (2010)
  • Author(s): Yokoyama C
  • Organizer: International Primatology Society XXIII Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-13
• [Presentation] Influence of propofol anesthesia on regional functional state of brain serotonin transporter; PET study with [11C]DASB in macaque monkeys (2010)
  • Author(s): Yamanaka H, Onoe K, Yokoyama C, Onoe H
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-10
• [Presentation] Functional associations of aromatase and serotonin transporters with social behavior: PET study with [11C] cetrozole and [11C] DASB in common marmosets (2010)
  • Author(s): Yokoyama C, Kawasaki A, Takahashi K, Hosoya T, Watanabe Y, Onoe H
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-10
• [Presentation] Influence of propofol anesthesia on regional functional state of brain serotonin transporter ; PET study with [^<11>C]DASB in macaque monkeys. (2010)
  • Author(s): Yamanaka H
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-10
• [Presentation] Functional associations of aromatase and serotonin transporters with social behavior : PET study with [^<11>C] cetrozole and [^<11>C] DASB in common marmosets. (2010)
  • Author(s): Yokoyama C
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-10
• [Presentation] Developmental Changes in p-glycoprotein function in the blood-brain barrier of non-human primates: PET study with R-[11C]verapamil (2010)
  • Author(s): Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Katayama Y, Wada Y, Onoe K, Nagata H, Doi H, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-09
• [Presentation] Developmental Changes in p-glycoprotein function in the blood-brain barrier of non-human primates : PET study with R-[^<11>C]verapamil. (2010)
  • Author(s): Takashima T
  • Organizer: 2010 World Molecular Imaging Congress
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-09-09
• [Presentation] プロポフォール麻酔は[11C]DASBのセロトニントランスポーターへの結合を上昇させる:マカクザルを用いたPET研究 (2010)
  • Author(s): 山中創、尾上嘉代、横山ちひろ、尾上浩隆
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 社会行動特性と脳内モノアミントランスポーターとの機能的関連:コモンマーモセットを用いたPET研究 (2010)
  • Author(s): 横山 ちひろ、川崎 章弘、 尾上 嘉代、尾上 浩隆
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] プロポフォール麻酔は[^<11>C]DASBのセロトニントランスポーターへの結合を上昇させる:マカクザルを用いたPET研究 (2010)
  • Author(s): 山中創
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 早期養育環境がコモンマーモセットの社会行動へ及ぼす影響
  • Author(s): 横山 ちひろ
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] コモンマーモセットにおける音声の個体識別と脳活動の相関
  • Author(s): 加藤 真樹
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] The midline cortical serotonergic system in social behavior traits: Positron emission tomography studies of common marmosets.
  • Author(s): Chihiro Yokoyama
  • Organizer: 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Book] From Genes to Animal Behavior (2011)
  • Author(s): Yokoyama C
  • Publisher: Springer
• [Remarks] 理化学研究所ホームページ 広報活動 プレスリリース(2012)
  • URL: http://www.riken.go.jp/pr/press/2012/20120718/
• [Remarks] サルの個性に脳のセロトニンが関係 －PETによる分子イメージングがヒトの社会性行動の原点を明らかに－
  • URL: http://www.riken.go.jp/pr/press/2012/20120718/
• [Remarks]
  • URL: http://www.cmis.riken.jp/lab03/laboratory03_content.html