| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
It is known that there is strain difference in the laboratory mice in the resistance/susceptibility to Sendai virus infection. It is, further, known that three QTLs are identified to be responsible for the resistance/susceptibility to Sendai virus infection, based on the QTL analysis using C57BL/6 (B6) and DBA/2 (D2) mice as a representative of the resistant and susceptible strains, respectively. In this research, we produced 6 congenic strains, in which 3 QTLS were introgressed into B6 and D2 mice, respectively. Further, we produced 2 congenic strains, in which 2 QTLs showing epistatic interaction were simultaneously introgressed into B6 and D2 mice, respectively. Using these 8 congenic strains, we conducted infection experiments with Sendai virus. We obtained results that these three introgressed QTLs invested resistance to D2 mice, thus confirming that genes responsible for resistance to Sendai virus infection should exist in these three QTLs.
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