Identification of genes responsible for resistance/susceptibility toSendai virus infection in the strain difference in mice.
| Project/Area Number |
22500381
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
AGUI Takashi 北海道大学, 大学院・獣医学研究科, 教授 (00212457)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | センダイウイルス / マウス / 感染抵抗性因子 / コンジェニックマウス / QTL / Quantitative trait loci / 感染抵抗性/感受性 |
|---|
| Research Abstract |
It is known that there is strain difference in the laboratory mice in the resistance/susceptibility to Sendai virus infection. It is, further, known that three QTLs are identified to be responsible for the resistance/susceptibility to Sendai virus infection, based on the QTL analysis using C57BL/6 (B6) and DBA/2 (D2) mice as a representative of the resistant and susceptible strains, respectively. In this research, we produced 6 congenic strains, in which 3 QTLS were introgressed into B6 and D2 mice, respectively. Further, we produced 2 congenic strains, in which 2 QTLs showing epistatic interaction were simultaneously introgressed into B6 and D2 mice, respectively. Using these 8 congenic strains, we conducted infection experiments with Sendai virus. We obtained results that these three introgressed QTLs invested resistance to D2 mice, thus confirming that genes responsible for resistance to Sendai virus infection should exist in these three QTLs.
|
Report
(4 results)
Research Products
(8 results)
-
-
[Journal Article] Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice.2011
Author(s)
Simon, A.Y., Sasaki, N., Ichii, O., Kajino, K., Kon, Y., and Agui, T.
-
Journal Title
Microbes Infect.
Volume: 13
Pages: 783-797
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
