Analysis of autoantibodies induced during progression to AIDS
| Project/Area Number |
22500387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
KUWATA Takeo 熊本大学, エイズ学研究センター, 助教 (70346063)
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| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Tatsuhiko 京都大学, ウイルス研究所, 教授 (90467431)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HIV / SIV / アカゲザル / エイズ / モノクローナル抗体 / ウイルス / 感染症 / 免疫学 |
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| Research Abstract |
The role of autoantibodies in CD4+T cell depletion during HIVinfection remains unclear. In this study, many antibodies against SIV and self antigenswere isolated by phage display method. Analysis of these antibodies revealed that theinduction of autoantibdies was not due to the cross-reactivity to SIV and suggested alow cytotoxic activity of autoantibodies in SIV infection.
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Report
(4 results)
Research Products
(18 results)
