Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levels
| Project/Area Number |
22500392
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
ABE Koichiro 東海大学, 医学部, 講師 (90294123)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKAMATSU Nobuhiko 北里大学, 理学部, 教授 (40206876)
ITO Michihiko 北里大学, 理学部, 准教授 (90240994)
KIMURA Minoru 東海大学, 医学部, 教授 (10146706)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 疾患モデル / 実験動物学 / 病態モデル / 自己炎症性症候群 / 関節炎 / シグナル伝達 / リン酸化 / マウス遺伝学 / 炎症 / ENU |
|---|
| Research Abstract |
The Ali18 mutation in an kinase gene causes inflammatory arthritis in mice. However, its molecular mechanisms remains largely unknown. Here we show that Ali18; W/Wv double mutant mice show no inflammatory arthritis. These results indicate the effects of the Ali18 mutation on mast cells trigger the initiation of inflammation.
|
Report
(4 results)
Research Products
(26 results)
-
-
[Journal Article] Hrabe de Angelis M. A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cg2 causes inflammatory arthritis, metabolic defects, and male fertility in vitro in a murine model2011
Author(s)
阿部幸一郎, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev, Klaften M, Adler T, Calazada-Wack, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Kingenspor M, Wolf E, Wurst W, Gailus-Durner V, Ka
-
Journal Title
Arthritis & Rheumatism
Volume: 63
Issue: 5
Pages: 1301-1311
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] ホスホリパーゼCγ2 の新規機能亢進型変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010
Author(s)
阿部幸一郎, Fuchs H, Boersma A, Yu P, Kalaydjiev S, Klaften M, Adler T, Hans W, Rathkolb B, Prehn C, Adamski J, Busch D, Wolf E, Gailus-Druner, Katan M, Marschall S, Wagner S, Hrabe de Angelis M
Organizer
日本実験動物学会総会
Place of Presentation
京都
Year and Date
2010-05-12
Related Report
-
-
-
-
-
-
-
-
-
-
-
