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Analysis of the inflammatory mechanisms caused by the Ali18 mutation in molecular and cellular levels

Research Project

Project/Area Number 22500392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionTokai University

Principal Investigator

ABE Koichiro  東海大学, 医学部, 講師 (90294123)

Co-Investigator(Renkei-kenkyūsha) TAKAMATSU Nobuhiko  北里大学, 理学部, 教授 (40206876)
ITO Michihiko  北里大学, 理学部, 准教授 (90240994)
KIMURA Minoru  東海大学, 医学部, 教授 (10146706)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords疾患モデル / 実験動物学 / 病態モデル / 自己炎症性症候群 / 関節炎 / シグナル伝達 / リン酸化 / マウス遺伝学 / 炎症 / ENU
Research Abstract

The Ali18 mutation in an kinase gene causes inflammatory arthritis in mice. However, its molecular mechanisms remains largely unknown. Here we show that Ali18; W/Wv double mutant mice show no inflammatory arthritis. These results indicate the effects of the Ali18 mutation on mast cells trigger the initiation of inflammation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Remarks (8 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012

    • Author(s)
      Abe, K. et al.
    • Journal Title

      Genesis

      Volume: 50 Issue: 10 Pages: 758-765

    • DOI

      10.1002/dvg.22035

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hrabe de Angelis M. A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cg2 causes inflammatory arthritis, metabolic defects, and male fertility in vitro in a murine model2011

    • Author(s)
      阿部幸一郎, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev, Klaften M, Adler T, Calazada-Wack, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Kingenspor M, Wolf E, Wurst W, Gailus-Durner V, Ka
    • Journal Title

      Arthritis & Rheumatism

      Volume: 63 Issue: 5 Pages: 1301-1311

    • DOI

      10.1002/art.30280

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between Wnt/b-catenin and TGF-b/BMP signals in the intervertebral disc cell2011

    • Author(s)
      Hiyama A, Skai D, 阿部幸一郎, Mochida J
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Issue: 5 Pages: 1139-1148

    • DOI

      10.1002/jcp.22438

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell2011

    • Author(s)
      Hiyama A., Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J(7人中6番目)
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Pages: 1139-1148

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel N-ethyl-N-nitrosourea-induced mutation in Phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model2011

    • Author(s)
      Abe K, Fuchs H, Boersoma A, et al., (28人中1番目)
    • Journal Title

      Arthritis & Rheumatism

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell2011

    • Author(s)
      Hiyama A.Sakai D, Tanaka M, Arai F, Nakajima D, Abe K, Mochida J, (7人中6番目)
    • Journal Title

      Journal of Cellular Physiology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of intervertebral disc cell senescence by Wnt/b-catenin signaling-induced matrix2010

    • Author(s)
      Hiyama A, Sakai D, Risbud MV, Tanaka M, Arai F, 阿部幸一郎, Mochida J
    • Journal Title

      Arthritis & Rheumatism

      Volume: 62 Issue: 10 Pages: 3036-3047

    • DOI

      10.1002/art.27599

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of intervertebral disc cell senescence by Wnt/β-catenin signaling-induced matrix metalloproteinase expression2010

    • Author(s)
      Hiyama A.Sakai D, Risbud MV, Tanaka M, Arai F, Abe K, Mochida J, (7人中6番目)
    • Journal Title

      Arthritis & Rheumatism

      Volume: 62 Pages: 3036-3047

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sktcreマウス系統を用いた脊柱椎間板におけるコンディショナルノックアウトシステムの構築2012

    • Author(s)
      阿部幸一郎,荒木喜美,谷河麻耶,仙波圭,安藤卓,佐藤正宏,酒井大輔,檜山明彦,持田讓治,山村研一
    • Organizer
      日本実験動物科学・技術九州2012
    • Place of Presentation
      別府
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] レチノイド投与による炎症性関節炎モデルマウスへの薬理作用2012

    • Author(s)
      阿部幸一郎,谷河麻耶,内藤佳津子,石川久美子,谷口真沙美
    • Organizer
      日本実験動物科学・技術 九州2012
    • Place of Presentation
      別府
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Sktcreマウス系統を用いた椎間板コンディショナルノックアウトシステムの構築2012

    • Author(s)
      阿部幸一郎
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府国際コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] レチノイド投与による炎症性関節炎モデルマウスへの薬理効果2012

    • Author(s)
      阿部幸一郎
    • Organizer
      第46回日本実験動物技術者協会総会
    • Place of Presentation
      別府国際コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ali14変異マウスを用いた受精におけるホスホリパーゼCγ2の機能解析2011

    • Author(s)
      荻原早苗、Auke Boersma, 本杉奈美、中村健司、Susan Marschall, Martin Hrabe de Angelis, 木村穣、阿部幸一郎
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intervertebral disc-specific expression of Cre recombinase in Sktcreknock-in mice2011

    • Author(s)
      阿部幸一郎, Araki K, Tanigawa M, Semba K, Imai K, Yamamura K-I
    • Organizer
      Cartilage Biology & Pathology (Gordon Research Conference)
    • Place of Presentation
      Ventura, California, USA
    • Year and Date
      2011-03-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ホスホリパーゼCγ2 の新規機能亢進型変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010

    • Author(s)
      阿部幸一郎, Fuchs H, Boersma A, Yu P, Kalaydjiev S, Klaften M, Adler T, Hans W, Rathkolb B, Prehn C, Adamski J, Busch D, Wolf E, Gailus-Druner, Katan M, Marschall S, Wagner S, Hrabe de Angelis M
    • Organizer
      日本実験動物学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ホスホリパーゼCg2新規機能亢進型突然変異であるAli14はマウスにおいて炎症性関節炎を引き起こす2010

    • Author(s)
      阿部幸一郎、Fuchs H, Boersma A, ら, (18人中1番目)
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Remarks] 東海大学 医学部 阿部幸一郎研究室

    • URL

      http://abe.med.u-tokai.ac.jp/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 東海大学 TWAVE

    • URL

      http://www.u-tokai.ac.jp/tweve/volume02_2/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 東海大学 TWAVE_PDF

    • URL

      http://www.u-tokai.ac.jp/international/about/twave.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 東海大学 医学部 阿部幸一郎研究室

    • URL

      http://abe.med.u-tokai.ac.jp/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東海大学 TWAVE

    • URL

      http://www.u-tokai.ac.jp/tweve/volume02_2/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東海大学 TWAVE_PDF

    • URL

      http://www.u-tokai.ac.jp/international/about/twave.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://abe.med.u-tokai.ac.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://abe.med.u-tokai.ac.jp/index.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 炎症性疾患又は骨粗鬆症のスクリーニング方法2010

    • Inventor(s)
      阿部幸一郎、マーティン フラベデ アンゲリス、ヘルムット フックス
    • Industrial Property Rights Holder
      学校法人東海大学
    • Filing Date
      2010-07-23
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 炎症性疾患又は骨粗鬆症の治療剤のスクリーニング方法2010

    • Inventor(s)
      阿部幸一郎, (他2名)
    • Industrial Property Rights Holder
      東海大学
    • Industrial Property Number
      2010-165551
    • Filing Date
      2010-07-23
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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