Analysis of relationship between age-dependent phenotype change and gene
| Project/Area Number |
22500396
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKAHASHI Eiki 独立行政法人理化学研究所, 動物資源開発支援ユニット, 支援ユニットリーダー (40446521)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 老化 / 表現型解析 / マウス / 行動解析 / QTL解析 / 運動量 / 記憶能力 / アルコール嗜好性 / 老化促進モデルマウス / 記憶 / 体外受精 / 加齢依存的表現型 |
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| Research Abstract |
In this study to examine the relationship between aging and behavioral changes, we used senescence-accelerated mouse (SAM) strain, behavioral tests including motor activity, memory, and alcohol preference tests, and QTL analyses. We have found chromosomal regions involved in age-dependent phenotype changes in the behavioral test. We are trying to identify the causative gene(s) using the database and other mutant strains.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation2012
Author(s)
Li W, Zhou Y, Tian X, Kim TY, Ito N, Watanabe K, Tsuji A, Aoyama Y, Niimi K, Arai T, Takahashi E
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Journal Title
PLoS ONE
Volume: 7
Issue: 8
Pages: e44230-e44230
DOI
Related Report
Peer Reviewed
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