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Immunosensor with Fluid Control Mechanism for Salivary Cortisol Analysis

Research Project

Project/Area Number 22500400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionIwate University

Principal Investigator

YAMAGUCHI Masaki  岩手大学, 工学部, 教授 (50272638)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords計測工学 / 生物・生体工学 / 分子認識 / 流体工学 / ストレス
Research Abstract

The clinical utility of salivary cortisol measurements has been restricted by the lack of appropriate technology platforms that allow near real-time" detection and quantification of salivary cortisol. Integrating early identification and risk stratification in patients with stress-related diseases will require that care providers have timely access to salivary stress biomarker data. The purpose of this research is to demonstrate a new design for a cortisol immunosensor for the noninvasive and quantitative analysis of salivary cortisol. We propose a cortisol immunosensor with a fluid control mechanism which has both a vertical flow and a lateral flow. The detected current resulting from a competitive reaction between the sample cortisol and a glucose oxidase-labeled cortisol conjugate was found to be inversely related to the concentration of cortisol in the sample solution. The measurement could be accomplished within 35 minutes and the cortisol immunosensor could be reused. Additionally, a novel saliva collection kit that can fix the saliva volume with only a four-step action was proposed. Used for evaluation of human salivary cortisol levels, the cortisol immunosensor measurement corresponded closely with commercially available ELISA method R^2 = 0.92) for a range of the concentrations of native salivary cortisol (0.1 . 10 ng/ml). Our results indicate the promise of the new cortisol immunosensor for noninvasive, point-of care measurement of human salivary cortisol levels.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (77 results)

All 2013 2012 2011 2010 Other

All Journal Article (34 results) (of which Peer Reviewed: 24 results) Presentation (26 results) (of which Invited: 1 results) Book (8 results) Remarks (4 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] 震災復興に貢献する唾液コルチゾール測定器の開発2013

    • Author(s)
      山口 昌樹,丹羽 大介
    • Journal Title

      機能材料

      Volume: Vol.33, No.1 Pages: 57-61

    • Related Report
      2012 Final Research Report
  • [Journal Article] 唾液ストレスマ-カ-と非侵襲的診断2012

    • Author(s)
      山口 昌樹
    • Journal Title

      Bio Industry

      Volume: Vol.29, No.10 Pages: 25-30

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunosensor with Fluid Control Mechanism for Salivary Cortisol Analysis2012

    • Author(s)
      Masaki Yamaguchi, Yohei Matsuda, Shohei Sasaki, Makoto Sasaki, Yoshihiro Kadoma, Yoshikatsu Imai, Daisuke Niwa, Vivek Shetty
    • Journal Title

      Biosensors & Bioelectronics

      Volume: Vol.41 Pages: 186-191

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of a Salivary Biosensor for Objective Assessment of Surgery-Related Stress2012

    • Author(s)
      Theodore F. Robles, Rassilee Sharma, Kwan-Soo Park, Lauren Harrell, Masaki Yamaguchi, and Vivek Shetty
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: Vol.70, No.10 Pages: 2256-2263

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Evaluation of the Chronic Influence of Local Air Velocity from an Air Conditioner using Salivary Cortisol and Skin Caspase-14 as Biomarkers of Psychosomatic and Environmental Stress2012

    • Author(s)
      M Yamaguchi and H Nishimiya
    • Journal Title

      The Journal of International Medical Research

      Volume: Vol.40, No.4 Pages: 1429-1437

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 唾液アミラーゼ活性を用いた月経周期に伴う女性のストレス評価2012

    • Author(s)
      中川 朝美,佐々木 誠,山口 昌樹
    • Journal Title

      ライフサポート

      Volume: Vol.24, No.3 Pages: 123-127

    • NAID

      10031117507

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patterns of Salivary Cortisol Levels Can Manifest Work Stress in Emergency Care Providers2012

    • Author(s)
      Yasushi Nakajima, Takayuki Takahashi, Vivek Shetty, Masaki Yamaguchi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: Vol.62, No.3 Pages: 191-197

    • NAID

      10030742235

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 唾液バイオマーカーによる精油の嗜好と生理反応の関連性の検証2012

    • Author(s)
      中野 敦行,長山 優,佐々木 誠,山口 昌樹
    • Journal Title

      アロマテラピー学雑誌

      Volume: Vol. 12, No.1 Pages: 34-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Analytical Technique for Measuring Protein Carbonyl in the Stratum Corneum Using Surface Plasmon Resonance2012

    • Author(s)
      Akira Date, Tomoki Shimakura, Makoto Sasaki, and Masaki Yamaguchi
    • Journal Title

      International Journal of Cosmetic Science

      Volume: Vol.34 Pages: 81-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patterns of Salivary Cortisol Levels Can Manifest Work Stress in Emergency Care Providers2012

    • Author(s)
      Yasushi Nakajima, Masaki Yamaguchi
    • Journal Title

      The Journal of Physiological Sciences

      Volume: Vol. 62 Issue: 3 Pages: 191-197

    • DOI

      10.1007/s12576-012-0197-8

    • NAID

      10030742235

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 唾液アミラーゼ活性を用いた月経周期に伴う女性のストレス評価2012

    • Author(s)
      中川 朝美,佐々木 誠,山口 昌樹
    • Journal Title

      ライフサポート

      Volume: Vol. 24 Pages: 123-127

    • NAID

      10031117507

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of a Salivary Biosensor for Objective Assessment of Surgery-Related Stress2012

    • Author(s)
      Theodore F., Masaki Yamaguchi, Vivek Shetty
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: Vol.70 Issue: 10 Pages: 2256-2263

    • DOI

      10.1016/j.joms.2012.03.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 唾液ストレスマ-カ-と非侵襲的診断2012

    • Author(s)
      山口 昌樹
    • Journal Title

      Bio Industry

      Volume: Vol. 29 Pages: 25-30

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 震災復興に貢献する唾液コルチゾール測定器の開発2012

    • Author(s)
      山口 昌樹,丹羽 大介
    • Journal Title

      機能材料

      Volume: Vol. 33 Pages: 57-61

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 唾液ベイオマーカーによる精油の嗜好と生理反応の関連性の検証2012

    • Author(s)
      中野敦行, 山口昌樹
    • Journal Title

      アロマテラピー学雑誌

      Volume: Vol.12(in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオマスプラスチックの医療用具への応用に向けて2011

    • Author(s)
      山口 昌樹
    • Journal Title

      プラスチックス

      Volume: Vol.62, No.6 Pages: 1-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] Salivary Sensors for Quantification of Stress Response Biomarker2011

    • Author(s)
      Masaki YAMAGUCHI and Vivek SHETTY
    • Journal Title

      Electrochemistry

      Volume: Vol.79, No.6 Pages: 442-446

    • NAID

      10028111829

    • Related Report
      2012 Final Research Report
  • [Journal Article] 唾液アミラーゼによるストレスの評価2011

    • Author(s)
      中野 敦行,山口 昌樹
    • Journal Title

      バイオフィードバック研究

      Volume: Vol.38, No.1 Pages: 3-9

    • NAID

      110008723109

    • Related Report
      2012 Final Research Report
  • [Journal Article] 救急医療従事者の夜間勤務が唾液アミラーゼ活性の日内変動へもたらす影響2011

    • Author(s)
      中島 康,高橋 貴之,山口 昌樹
    • Journal Title

      日本救急医学会雑誌

      Volume: Vol. 22, No.3 Pages: 117-124

    • NAID

      10029087029

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental validation of a point-of-care, salivary α-amylase biosensor2011

    • Author(s)
      Vivek Shetty, Corwin Zigler, Theodore F. Robles, David Elashoff, Masaki Yamaguchi
    • Journal Title

      Psychoneuroendocrinology

      Volume: Vol.36, No.2 Pages: 193-199

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Facial Expression of Mother on 15-21-Month-Old Infants Using Salivary Biomarker2011

    • Author(s)
      Akiko Tange, Megumi Mino, Kiyoshi Miyazawa, Kazuo Hiraki, Syohji Itakura and Masaki Yamaguchi
    • Journal Title

      Sensors and Materials

      Volume: Vol. 23, No.1 Pages: 87-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The feasibility of ambulatory biosensor measurement of salivary alpha amylase: Relationships with self-reported and naturalistic psychological stress2011

    • Author(s)
      Theodore F. Robles, Vivek Shetty, Corwin M. Zigler, Dorie A. Glover, David Elashoff, Debra Murphy, Masaki Yamaguchi
    • Journal Title

      Biological Psychology

      Volume: Vol. 86, No.1 Pages: 50-56

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 救急医療従事者の夜間勤務が唾液アミラーゼ活性の日内変動へもたらす影響2011

    • Author(s)
      中島康, 山口昌樹
    • Journal Title

      日本救急医学会雑誌

      Volume: Vol.22 Pages: 117-124

    • NAID

      10029087029

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 唾液アミラーゼによるストレスの評価2011

    • Author(s)
      中野敦行, 山口昌樹
    • Journal Title

      バイオフィードバック研究

      Volume: Vol.38 Pages: 3-9

    • NAID

      110008723109

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Salivary Sensors for Quantification of Stress Response Biomarker2011

    • Author(s)
      Masaki YAMAGUCHI, Vivek SHETTY
    • Journal Title

      Electrochemistry

      Volume: Vol.79 Pages: 442-446

    • NAID

      10028111829

    • Related Report
      2011 Annual Research Report
  • [Journal Article] バイオマスプラスチックの医療用具への応用に向けて2011

    • Author(s)
      山口昌樹
    • Journal Title

      プラスチックス

      Volume: Vol.62 Pages: 1-4

    • Related Report
      2011 Annual Research Report
  • [Journal Article] An Analytical Technique for Measuring Protein Carbonyl in the Stratum Comeum Using Surface Plasmon Resonance2011

    • Author(s)
      Akira Date, Masaki Yamaguchi
    • Journal Title

      International Journal of Cosmetic Science

      Volume: Vol.34 Issue: 1 Pages: 81-85

    • DOI

      10.1111/j.1468-2494.2011.00684.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The feasibility of ambulatory biosensor measurement of salivary alpha amylase: Relationships with self-reported and naturalistic psychological stress2011

    • Author(s)
      Theodore F.Robles, Masaki Yamaguchi
    • Journal Title

      Biological Psychology

      Volume: Vol.86 Pages: 50-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Facial Expression of Mothcr on 15-21-Month-Old Infants Using Salivary Biomarker2011

    • Author(s)
      Akiko Tange, Masaki Yamaguchi
    • Journal Title

      Sensors and Materials

      Volume: Vol.23 Pages: 87-94

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental validation of apoint-of-care, salivary α-amylase biosensor2011

    • Author(s)
      Vivek Shetty, Masaki Yamaguchi
    • Journal Title

      Psychoneuroendocrinology

      Volume: Vol.36 Pages: 193-199

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunochromatographic cortisol biosensor using enzyme-labeled conjugate2010

    • Author(s)
      Yusuke Tahara, Suguru Yoshikawa, Vivek Shetty, and Masaki Yamaguchi
    • Journal Title

      Sensors and Materials

      Volume: Vol. 22, No.8 Pages: 427-437

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of local air velocity from air conditioner evaluated by salivary and skin biomarkers2010

    • Author(s)
      Masaki Yamaguchi, Takayuki Takahashi, Yuichiro Yoshino, Makoto Sasaki, Hajime Nishimiya
    • Journal Title

      Building & Environment

      Volume: Vol.45, No.11 Pages: 2539-2544

    • NAID

      120002519152

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of local air velocity from air conditioner evaluated by salivary and skin biomarkers2010

    • Author(s)
      Masaki Yamaguchi
    • Journal Title

      Building & Environment

      Volume: Vol.45 Pages: 2539-2544

    • NAID

      120002519152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunochromatographic cortisol biosensor using enzyme-labeled conjugate2010

    • Author(s)
      Yhsuke Tahara, Masaki Yamaguchi
    • Journal Title

      Sensors and Materials

      Volume: Vol.22 Pages: 427-437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ホルモン分析の自動化を目指した唾液採取器具の提案2012

    • Author(s)
      手塚 勇希,佐々木 翔平,松田 陽平,今井 義勝,丹羽 大介,佐々木 誠,山口 昌樹
    • Organizer
      第46回日本生体医工学会東北支部大会講演論文集,ME-B1-1
    • Place of Presentation
      東北大学 (仙台市)
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 内分泌系の尺度に用いる唾液コルチゾール測定器の開発2012

    • Author(s)
      丹羽 大介,今井 義勝,浜地 健次,佐々木 誠,山口 昌樹
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2012講演論文集 ,OS2-7-2
    • Place of Presentation
      名古屋大学 (名古屋市)
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Fabrication of Semi-invasive Micro-needle Array Using Gradation Exposure2012

    • Author(s)
      M. Yamaguchi, Y. Sasaki, Y. Kimura, M. Sasaki
    • Organizer
      Pacific Rim Meeting on Electrochemical and Solid-state Science (PRiME2012)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, HI (USA)(ECS Transactions: Chemical Sensors 8, No. 2029, The Electrochemical Society)
    • Year and Date
      2012-10-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Detected Current Characteristics of Cortisol Sensor with Fluid Controlling Mechanism2012

    • Author(s)
      Shohei Sasaki, Yohei Matuda, Imai Yoshikatu, Daisuke Niwa, Masaki Yamaguchi
    • Organizer
      日本生体医工学会大会プログラム・論文集 ,Vol.50,Suppl.1,O2-05-2
    • Place of Presentation
      福岡国際会議場 (福岡市)
    • Year and Date
      2012-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液マーカーを用いたストレス可視化技術2012

    • Author(s)
      山口 昌樹
    • Organizer
      日本繊維製品消費科学会 第43回快適性を考えるシンポジウム
    • Place of Presentation
      京都市産業技術研究所 (京都市)
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Detected Current Characteristics of Cortisol Sensor with Fluid Controlling Mechanism2012

    • Author(s)
      Shohei Sasaki, Masaki Yamaguchi
    • Organizer
      第45回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場 (福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fabrication of Semi-invasive Micro-needle Array Using Gradation Exposure2012

    • Author(s)
      M. Yamaguchi, Y. Sasaki, Y. Kimura, M. Sasaki
    • Organizer
      Pacific Rim Meeting on Electrochemical and Solid-state Science (PRiME2012)
    • Place of Presentation
      Honolulu, HI (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 内分泌系の尺度に用いる唾液コルチゾール測定器の開発2012

    • Author(s)
      丹羽 大介,山口 昌樹
    • Organizer
      生活生命支援医療福祉工学系学会連合大会
    • Place of Presentation
      名古屋大学 (名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非侵襲バイオマーカーを用いた空調機器の快適性評価2011

    • Author(s)
      山口 昌樹,吉野 雄一朗,佐々木 誠,西宮 肇
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2011講演論文集 ,O1-1 (2011)
    • Place of Presentation
      芝浦工業大学 (港区)
    • Year and Date
      2011-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 非侵襲バイオマーカーを用いた空調機器の快適性評価2011

    • Author(s)
      山口昌樹
    • Organizer
      生活生命支援医療福祉工学系学会連合大会
    • Place of Presentation
      東京電機大学(東京都)
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 物質輸送と抗原抗体反応の連成解析によるイムノセンサの基礎設計2011

    • Author(s)
      木村 勇太,佐々木 誠,山口 昌樹
    • Organizer
      第45回日本生体医工学会東北支部大会講演論文集,ME-o3-1 (2011)
    • Place of Presentation
      岩手大学 (盛岡市)
    • Year and Date
      2011-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 流体制御機構を備えたコルチゾールセンサの検出電流の評価2011

    • Author(s)
      佐々木 翔平,松田 陽平,今井 義勝,丹羽 大介,佐々木 誠,山口 昌樹
    • Organizer
      第45回日本生体医工学会東北支部大会講演論文集,ME-o1-3
    • Place of Presentation
      岩手大学 (盛岡市)
    • Year and Date
      2011-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 流体制御機構を備えたコルチゾールセンサの検出電流の評価2011

    • Author(s)
      山口昌樹
    • Organizer
      第45回日本生体医工学会東北支部大会
    • Place of Presentation
      岩手医科大学(盛岡市)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 物質輸送と抗原抗体反応の連成解析によるイムノセンサの基礎設計2011

    • Author(s)
      山口昌樹
    • Organizer
      第45回日本生体医工学会東北支部大会
    • Place of Presentation
      岩手医科大学(盛岡市)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Novel Analytical Technique of Skin Photo-stress Biomarker Using Surface Plasmon Resonance2010

    • Author(s)
      Masaki Yamaguchi, Tomoki Shimakura, Akira Date, Makoto Sasaki
    • Organizer
      5th Cairo International Biomedical Engineering Conference (CIBEC2010), 3050 (December, 2010) 240-243
    • Place of Presentation
      Sheraton Cairo Hotel, Cairo (Egypt)
    • Year and Date
      2010-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液による非侵襲的な生体情報計測2010

    • Author(s)
      山口 昌樹
    • Organizer
      次世代センサ協議会 次世代センサ総合シンポジウム
    • Place of Presentation
      東京ビッグサイト (江東区)
    • Year and Date
      2010-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液による非侵襲的な生体情報計測2010

    • Author(s)
      山口昌樹
    • Organizer
      次世代センサ総合シンポジウム
    • Place of Presentation
      東京ビッグサイト(江東区)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Novel Analytical Technique of Skin Photo-stress Biomarker Using Surface Plasmon Resonance2010

    • Author(s)
      Masaki Yamaguchi
    • Organizer
      5th Cairo International Biomedical Engineering Conference(CIBEC2010)
    • Place of Presentation
      Cairo, Egypt
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 唾液ストレス検査の展望2010

    • Author(s)
      山口 昌樹
    • Organizer
      第38回日本バイオフィードバック学会学術総会教育講演
    • Place of Presentation
      岩手大学 (盛岡市)
    • Year and Date
      2010-07-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液ストレス検査の展望2010

    • Author(s)
      山口昌樹
    • Organizer
      第38回日本バイオフィードバック学会学術総会
    • Place of Presentation
      岩手大学(盛岡市) 招待講演
    • Year and Date
      2010-07-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Digital Simulation of Immunosensor for Hormone Measurement Using Finite Element Method2010

    • Author(s)
      M. Yamaguchi, T. Takahashi, Y. Tahara, M. Sasaki, V. Shetty
    • Organizer
      The 13th International Meeting on Chemical Sensors (IMCS13)
    • Place of Presentation
      The University of Western Australia, Perth, Australia
    • Year and Date
      2010-07-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Digital Simulation of Immunosensor of Hormone Measurement Using Finite Element Metyod2010

    • Author(s)
      Masaki Yamaguchi
    • Organizer
      The 13th International Meeting on Chemical Sensors(IMCS13)
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 唾液ストレスマーカーの種類と使い方2010

    • Author(s)
      山口 昌樹
    • Organizer
      社団法人自動車技術会音質評価技術部門委員会
    • Place of Presentation
      中央大学 (文京区)
    • Year and Date
      2010-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液ストレスマーカーの種類と使い方2010

    • Author(s)
      山口昌樹
    • Organizer
      社団法人自動車技術会
    • Place of Presentation
      中央大学(文京区) 招待講演
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 唾液マーカーを用いたストレス可視化技術

    • Author(s)
      山口 昌樹
    • Organizer
      日本繊維製品消費科学会 第43回快適性を考えるシンポジウム
    • Place of Presentation
      京都市産業技術研究所 (京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ホルモン分析の自動化を目指した唾液採取器具の提案

    • Author(s)
      手塚 勇希,山口 昌樹
    • Organizer
      日本生体医工学会東北支部大会
    • Place of Presentation
      東北大学 (仙台市)
    • Related Report
      2012 Annual Research Report
  • [Book] Human Olfactory Displays and Interfaces: Odor Sensing and Presentation, - Evaluating the Psychobiologic Effects of Fragrances through Salivary Biomarkers -2012

    • Author(s)
      Takamichi Nakamoto Eds., Masaki Yamaguchi and Vivek Shetty
    • Publisher
      IGI Global, Hershey
    • Related Report
      2012 Final Research Report
  • [Book] Human Olfactory Displays and Interfaces: Odor Sensing and Presentation, -Evaluating the Psychobiologic Effects of Fragrances through Salivary Biomarkers-2012

    • Author(s)
      Takamichi Nakamoto Eds., Masaki Yamaguchi and Vivek Shetty
    • Publisher
      IGI Global
    • Related Report
      2012 Annual Research Report
  • [Book] 災害ストレスの対処法2011

    • Author(s)
      山口 昌樹,中島 康,中山 友紀
    • Publisher
      講談社サイエンティフィク,東京
    • Related Report
      2012 Final Research Report
  • [Book] 災害ストレスの対処法2011

    • Author(s)
      山口昌樹, 中島康, 中山友紀
    • Total Pages
      136
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2011 Annual Research Report
  • [Book] 体外診断用医薬品の開発と承認申請,第10章12節 唾液バイオマーカーによる非侵襲検査のニーズとシーズ2010

    • Author(s)
      菅原 隆編,山口 昌樹(分担執筆)
    • Publisher
      (株)報協会,東京
    • Related Report
      2012 Final Research Report
  • [Book] Oral and Maxillofacial Surgery Clinics of North America, Collaborative Care of the Facial Injury Patient, - Salivary Biosensors for Screening Trauma related Psychopathology-2010

    • Author(s)
      Vivek Shetty and Grant N. Marshall Eds., Vivek Shetty and Masaki Yamaguchi
    • Publisher
      Elsevier, Inc., New York
    • Related Report
      2012 Final Research Report
  • [Book] Oral and Maxillofacial Surgery Clinics of North America, Collaborative Care of the Facial Injury Patient, -Salivary Biosensors for Screelling Trauma related Psychopathology-2010

    • Author(s)
      Vivek Shetty, Grant N. Marshall Eds., Vivek Shetty, Masaki Yhmaguchi(分担執筆)
    • Publisher
      Elsevier, Inc.
    • Related Report
      2010 Annual Research Report
  • [Book] 体外診断用医薬品の開発と承認申請,第10章12節 唾液バイオマーカーによる非侵襲検査のニーズとシーズ2010

    • Author(s)
      菅原隆編, 山口昌樹(分担執筆)
    • Publisher
      (株)技術情報協会
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.mech.iwate-u.ac.jp/~yamaguchi/

    • Related Report
      2012 Final Research Report
  • [Remarks] 岩手大学 山口・佐々木研究室

    • URL

      http://www.mech.iwate-u.ac.jp/~yamaguchi/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.mech.iwate-u.ac.jp/~yamaguchi/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.mech.iwate-u.ac.jp/~yamaguchi/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 共振型質量センサ2013

    • Inventor(s)
      山口 昌樹
    • Industrial Property Rights Holder
      岩手大学
    • Industrial Property Number
      2013-028481
    • Filing Date
      2013-02-16
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] 検体採取器具2012

    • Inventor(s)
      今井 義勝,丹羽 大介,山口 昌樹
    • Industrial Property Rights Holder
      ローム(株),岩手大学
    • Industrial Property Number
      2012-085188
    • Filing Date
      2012-04-04
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 検体採取器具2012

    • Inventor(s)
      今井 義勝,丹羽 大介,山口 昌樹
    • Industrial Property Rights Holder
      ローム㈱,岩手大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-085188
    • Filing Date
      2012-04-04
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 金型,その製造方法,金型を用いた樹脂成形体の製造方法並びにその製造方法によって製造された樹脂成形体2010

    • Inventor(s)
      山口 昌樹,佐々木 誠,廣瀬 宏一
    • Industrial Property Rights Holder
      岩手大学
    • Industrial Property Number
      2010-211444
    • Filing Date
      2010-09-21
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 金型,その製造方法,金型を用いた樹脂成形体の製造方法用並びにその製造方法によつて並製造された樹脂成形体2010

    • Inventor(s)
      山口昌樹, 佐々木誠, 廣瀬宏一
    • Industrial Property Rights Holder
      岩手大学
    • Industrial Property Number
      2010-211444
    • Filing Date
      2010-09-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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