| Project/Area Number |
22500409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SAEKI Souichi 山口大学, 大学院・医学系研究科, 准教授 (50335767)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 多機能OCT / バイオメカニクス / バイオマテリアル / 複合材料工学 / 生体情報計測 / バイオイメージング / 生体材料学 / 医用生体工学 / スキンメカニクス / 軟骨ダイナミクス / 実験力学 / 人間医工学 / 生体材料科学 / 光可視化工学 |
|---|
| Research Abstract |
In this study, based on micro-tomographical visulalizing capability of OCT, multi-functional OCT was developed, which could extract a variety of biological functional information from low-coherence interference signals of tissue. OCSA and OCSE were constructed as two diagnostic systems of micro bio-mechanical properties, e.g. strain and stress, respectively. Furthermore, OCM were also built up as a biochemical monitoring system of water content in tissue. After some validation studies, OCSA and OCM were in vivo applied to skin and cartilage tissue to observe OCSE was applied to engineering polymer materials so as to verify stress visualization. As a result, the proposed multi-function OCT was proven to be an effective tool of biological diagnosis.
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