| Project/Area Number |
22500411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University |
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Principal Investigator |
SHIMODA Seiya 熊本大学, 大学院・生命科学研究部, 講師 (60398203)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Noboru 熊本大学, 大学院・生命科学研究部, 准教授 (90335795)
ARAKI Eiichi 熊本大学, 大学院・生命科学研究部, 教授 (10253733)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 人工臓器工学 / 再生医工学 / 人工膵島 / ブドウ糖センサ / インスリン注入アルゴリズム / インスリン注入ポンプ / 皮下注入アルゴリズム |
|---|
| Research Abstract |
We applied the artificial endocrine pancreas (AEP) system with PIsensor and a closed-loop subcutaneous insulin infusion algorithm developed for glycemiccontrol in diabetic dogs. The use of the WAEP system resulted in excellent glycemic controlafter a meal load of 80 kcal/kg (post-challenge blood glucose levels: from 70.2 to 181.8mg/dL), without any hypoglycemia. Thus, the new AEP with PI sensor and a closed-loopsubcutaneous insulin infusion algorithm developed is potentially suitable for clinicalapplication.
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