Imaging of oxidant stress in brain ischemia using an electromagnetic horn type ESR spectrometer
| Project/Area Number |
22500412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Oita University |
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Principal Investigator |
KAMIDA Tohru 大分大学, 医学部脳神経外科, 講師 (90315333)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tadashi 大分大学, 工学部, 名誉教授 (30100936)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 医用 / 生体画像 / 電磁ホーン型ESRイメージング装置 / 3次元局所ESR信号検出方式ESR / 悪性脳腫瘍 / スピンラベル剤 / 電磁ホーン型ESR装置 / 3次元局所ESR信号検出方式ESRイメージング装置 / マウス脳腫瘍モデル / フリーラジカル / L-band電磁ホーン型ESR装置 / マウス痙攣重積モデル / 生体試料上下移動装置 |
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| Research Abstract |
Imaging of a free radical in the living body is useful at diagnosis of the disease of oxidant stress origin, etc. In order to perform ESR measurement of a living specimen in a status epilepticus and a brain tumor models, L-band electromagnetic horn type ESR spectrometer was developed, and compared with the conventional loop gap resonator. Although ESR measurement was completed in each model at the latter, it was difficult for a low sensitivity in the former. Combining Q-band electromagnetic horn type ESR spectrometer with a three-dimensional local ESR signal detecting ESR imaging spectrometer was devised as a remedy.
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Report
(4 results)
Research Products
(10 results)
