| Project/Area Number |
22500422
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Toyama Industrial Technology Center, |
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Principal Investigator |
OHNAGA Takashi 富山県工業技術センター, 中央研究所, 研究員 (10416133)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Yutaka 富山大学, 大学院医学薬学研究部, 准教授 (30216072)
KISHI Hiroyuki 富山大学, 大学院医学薬学研究部, 准教授 (60186210)
OBATA Tsutomu 富山県工業技術センター, 中央研究所, 研究員 (30416143)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生体情報・計測 / 腫瘍細胞 / マイクロ流体チップ / 血中循環腫瘍細胞 / マイクロ流体デバイス / 光硬化性樹脂 / 上皮細胞接着分子 / 抗体 / 癌 / 転移 / マイクロチップ / 癌細胞株 / 細胞捕捉率 / 末梢血 / 単離 / EpCAM抗体 |
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| Research Abstract |
We developed polymeric microfluidic chips for isolation of rare circulating tumor cells (CTCs) in blood. The chips exhibited capture efficiency more than 90% owing to their specific surface functionality. Cost and productivity of the chip were so practical that the chips have been commercially available at a price less than one tenth of that of the conventional chips. CTCs from patient blood were confirmed to be captured with the chip.
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