Development of image guided radiation therapy system using synchrotron radiation

• Project/Area Number: 22500423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: 公益財団法人高輝度光科学研究センター (2012); Japan Synchrotron Radiation Research Institute (2010-2011)
• Principal Investigator: UMETANI Keiji 公益財団法人高輝度光科学研究センター, 利用研究促進部門, 主幹研究員 (50344396)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 医用 / 生体画像 / 放射線治療 / 照射野確認画像 / 放射光 / 屈折コントラストイメージング

Research Abstract

High-dose radiation destroys cancer cells in radiation therapy. Verification imaging is performed to adjust the patient’s osition to precisely target the tumor. We have applied a refraction contrast imaging technique to verification imaging to improve the accuracy of radiation treatment. The edge enhancement effect in refraction contrast imaging can produces higher contrast ages than those in conventional imaging. In this study, laboratory-animal images were obtained by the refraction contrast imaging and conventional imaging for the aluation of image quality improvement.

Research Products

• [Journal Article] Rat coronary microangiography system for preclinical imaging using synchrotron radiation (2013)
  • Author(s): Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai
  • Journal Title: Proc. SPIE Medical Imaging Volume: 8668 Pages: 866864-866864
  • DOI: 10.1117/12.2006570
  • Peer Reviewed
• [Journal Article] Stochastic tracking of small pulmonary vessels in human lung alveolar walls using synchrotron radiation micro CT images (2013)
  • Author(s): Yoshiki Kawata, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hironobu Ohamatsu, Noriyuki Moriyama, Harumi Itoh
  • Journal Title: Proc. SPIE Medical Imaging Volume: 8672 Pages: 867211-867211
  • DOI: 10.1117/12.2006895
  • Peer Reviewed
• [Journal Article] X-ray intravital microscopy for functional imaging in rat hearts using synchrotron radiation coronary microangiography (2013)
  • Author(s): Keiji Umetani, Kazuhito Fukushima
  • Journal Title: Rev Sci Instrum Volume: 84(3) Issue: 3
  • DOI: 10.1063/1.4795830
  • Peer Reviewed
• [Journal Article] Synchrotro radiation imaging for advancing our understanding of ardiovascular function (2013)
  • Author(s): Mikiyasu Shirai, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Keiji Umetani, Naoto Yagi, James T. Pearson
  • Journal Title: Circ Res Volume: 112(1) Issue: 1 Pages: 209-221
  • DOI: 10.1161/circresaha.111.300096
  • Peer Reviewed
• [Journal Article] A method for determining the modulation transfer function from thick microwire profiles measured with x-ray microcomputed tomography (2012)
  • Author(s): Y.Nakaya, Y.Kawata, N.Niki, K.Umetani, H.Ohmatsu, N.Moriyama
  • Journal Title: Medical Physics Volume: Vol.39, No.7 Issue: 7Part1 Pages: 4347-4364
  • DOI: 10.1118/1.4729711
  • Peer Reviewed
• [Journal Article] Evaluating the peak-to-valley dose ratio of synchrotron microbeams using PRESAGE fluorescence (2012)
  • Author(s): N. Annabell, N. Yagi, K. Umetani, C. Wong, M. Geso
  • Journal Title: J Synchrotron Rad Volume: 19 Issue: 3 Pages: 332-339
  • DOI: 10.1107/s0909049512005237
  • Peer Reviewed
• [Journal Article] Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo (2012)
  • Author(s): Jenkins MJ, Edgley AJ, Sonobe T, Umetani K, Schwenke DO, Fujii Y, Brown RD, Kelly DJ, Shirai M, Pearson JT
  • Journal Title: Arterioscler Thromb Vase Biol Volume: 32 Issue: 2 Pages: 370-377
  • DOI: 10.1161/atvbaha.111.237172
  • Peer Reviewed
• [Journal Article] Refraction Contrast Imaging Using Synchrotron Radiation for Image-Guided Radiation Therapy (2012)
  • Author(s): 梅谷啓二，近藤 威
  • Journal Title: The Journal of The Institute of Image Information and Television Engineers Volume: 66 Issue: 7 Pages: J230-J232
  • DOI: 10.3169/itej.66.J230
  • NAID: 130002111336
  • ISSN: 1342-6907, 1881-6908
  • Peer Reviewed
• [Journal Article] Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo (2012)
  • Author(s): M.J.Jenkins, A.J.Edgley, T.Sonobe, K.Umetani, et al
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 32 Pages: 370-377
  • Peer Reviewed
• [Journal Article] Micro-scale dose distribution of microbeam X rays: measurement and MC calculation (2011)
  • Author(s): N. Nariyama, K. Umetani, K. Shinohara, T. Kondoh, A. Kurihara, M. Fukumoto
  • Journal Title: Prog Nucl Sci Technol Volume: 2 Pages: 312-317
  • URL: http://www.aesj.or.jp/publication/pnst002/data/312-317.pdf
  • Peer Reviewed
• [Journal Article] Exogenous ghrelin improves blood flow distribution in pulmonary hypertension-assessed using synchrotron radiation microangiography (2011)
  • Author(s): Schwenke DO, Gray EA, Pearson JT, Sonobe T, Ishibashi-Ueda H, Campillo I, Kangawa K, Umetani K, Shirai M
  • Journal Title: Pflugers Arch Volume: 462 Issue: 3 Pages: 397-406
  • DOI: 10.1007/s00424-011-0992-8
  • Peer Reviewed
• [Journal Article] Development of synchrotron radiation X-ray intravital microscopy for in vivo imaging of rat heart vascular function (2011)
  • Author(s): Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai
  • Journal Title: Proc. 33rd Annual Internationa Conference of the IEEE EMBS Pages: 7791-7794
  • DOI: 10.1109/iembs.2011.6091920
  • Peer Reviewed
• [Journal Article] Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography (2011)
  • Author(s): Sonobe T, Schwenke DO, Pearson JT, Yoshimoto M, Fujii Y, Umetani K, Shirai M
  • Journal Title: J Appl Physiol Volume: 111 Issue: 1 Pages: 75-80
  • DOI: 10.1152/japplphysiol.00205.2011
  • Peer Reviewed
• [Journal Article] Narrow microbeam is more effective for tumor growth suppression than wide microbeam : experimental study using human glioma cells (2011)
  • Author(s): Atsushi Uyama, Takeshi Kondoh, Nobuteru Nariyama, Keiji Umetani, Ai Kurihara, Manabu Fukumoto, Kunio Shinohara, Eiji Kohmura
  • Journal Title: J Synchrotron Rad Volume: 18 Issue: 4 Pages: 671-678
  • DOI: 10.1107/s090904951101185x
  • Peer Reviewed
• [Journal Article] Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of the secondary pulmonary lobule (2011)
  • Author(s): Yoshiki Kawata
  • Journal Title: Proc.SPIE Medical Imaging Volume: 7965 Pages: 79651P-79651P
  • DOI: 10.1117/12.877938
  • Peer Reviewed
• [Journal Article] Role of rho kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension (2011)
  • Author(s): Daryl Schwenke, James Pearson, Takashi Sonobe, Hatsue Ishibashi-Ueda, Akito Shimouchi, Kenji Kangawa, Keiji Umetani, Mikiyasu Shirai
  • Journal Title: J Appl Physiol Volume: 110 Issue: 4 Pages: 901-908
  • DOI: 10.1152/japplphysiol.01318.2010
  • Peer Reviewed
• [Journal Article] Development of Synchrotron Radiation X-ray Intravital Microscopy for In Vivo Imaging of Rat Heart Vascular Function (2011)
  • Author(s): K.Umetani, J.T.Pearson, D.O.Schwenke, M.Shirai
  • Journal Title: Proc.33rd Annual International Conference of the IEEE EMBS Pages: 7791-7794
  • Peer Reviewed
• [Journal Article] Micro-Scale Dose Distribution of Microbeam X Rays : Measurement and MC Calculation (2011)
  • Author(s): N.Nariyama, K.Umetani, et al
  • Journal Title: Progress in Nuclear Science and Technology Volume: 2 Pages: 312-317
  • Peer Reviewed
• [Journal Article] Narrow microbeam is more effective for tumor growth suppression than wide microbeam : experimental study using human glioma cells (2011)
  • Author(s): A.Uyama, T.Kondoh, N.Nariyama, K.Umetani
  • Journal Title: Journal of Synchrotron Radiation Volume: 18 Pages: 671-678
  • Peer Reviewed
• [Journal Article] Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography (2011)
  • Author(s): T.Sonobe, D.O.Schwenke, J.T.Pearson, M.Yoshimoto, Y.Fujii, K.Umetani, M.Shirai
  • Journal Title: Journal of Applied Physiology Volume: 111 Pages: 75-80
  • Peer Reviewed
• [Journal Article] Role of Rho Kinase Signaling and Endothelial Dysfunction in Modulating Blood Flow Distribution in Pulmonary Hypertension (2011)
  • Author(s): Daryl Schwenke, James Pearson, Keiji Umetani, et al.
  • Journal Title: Journal of Applied Physiology Volume: 110 Pages: 901-908
  • Peer Reviewed
• [Journal Article] Coronary vascular dysfunction promoted by oxidative-nitrative tress in SHRSP.Z-Lepr(fa) (2010)
  • Author(s): Satomi Kagota, Kazuhito Fukushima, Keiji Umetani, Yukari Tada, Namie Nejime, Kazuki Nakamura, Hidezo Mori, Kazuro Sugimura, Masaru Kunitomo, Kazumasa Shinozuka
  • Journal Title: IzmDmcr rats with metabolic syndrome, Clin Exp Pharmacol Physiol Volume: 37(11) Issue: 11 Pages: 1035-1043
  • DOI: 10.1111/j.1440-1681.2010.05432.x
  • Peer Reviewed
• [Journal Article] Observation of intravascular changes of superabsorbent polymer microsphere (SAP-MS) with monochromatic X-ray imaging (2010)
  • Author(s): Daigo Tanimoto, Katsuyoshi Ito, Akira Yamamoto, Teruki Sone, Makito Kobatake, Tsutomu Tamada, Keiji Umetani
  • Journal Title: Cardiovasc Intervent Radiol Volume: 33(5) Issue: 5 Pages: 1016-1021
  • DOI: 10.1007/s00270-010-9857-3
  • Peer Reviewed
• [Journal Article] Coronary vascular dysfunction promoted by oxidative-nitrative stress in SHRSP.Z-Lepr(fa) /IzmDmcr rats with metabolic syndrome (2010)
  • Author(s): Satomi Kagota, Kazuhito Fukushima, Keiji Umetani, et al.
  • Journal Title: Clinical and Experimental Pharmacology and Physiology Volume: 37 Pages: 1035-1043
  • Peer Reviewed
• [Journal Article] Observation of Intravascular Changes of Superabsorbent Polymer Microsphere (SAP-MS) with Monochromatic X-Ray Imaging (2010)
  • Author(s): Daigo Tanimoto, Katsuyoshi Ito, Keiji Umetani, et al.
  • Journal Title: Cardiovascular and Interventional Radiology Volume: 33 Pages: 1016-1021
  • Peer Reviewed
• [Presentation] Rat coronary microangiography system for preclinical imaging using synchrotron radiation (2013)
  • Author(s): Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: Disney's Coronado Springs Resort, Orlando, Florida, USA
  • Year and Date: 2013-02-13
• [Presentation] Stochastic tracking of small pulmonary vessels in human lung alveolar walls using synchrotron radiation micro CT images (2013)
  • Author(s): Yoshiki Kawata, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hironobu Ohamatsu, Noriyuki Moriyama, Harumi Itoh
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: Disney's Coronado Springs Resort, Orlando, Florida, USA.
  • Year and Date: 2013-02-11
• [Presentation] マイクロビーム放射線治療での照射位置確認のための屈折コントラスト法による白色X線イメージング (2013)
  • Author(s): 梅谷啓二,成山展照,近藤 威
  • Organizer: 第26回日本放射光学会年会・放射光科学合同シンポジウム
  • Place of Presentation: 名古屋大学,愛知県名古屋市
  • Year and Date: 2013-01-14
• [Presentation] Rat coronary microangiography system for preclinical imaging using synchrotron radiation (2013)
  • Author(s): Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: Orlando, Florida
• [Presentation] 放射光生体顕微鏡によるラット心での前臨床イメージン (2013)
  • Author(s): 梅谷啓二、James T. Pearson、Daryl O. Schwenke、白井幹康
  • Organizer: 映像情報メディア学会年次大会
  • Place of Presentation: 広島市
• [Presentation] 放射光生体顕微鏡によるラット心での前臨床イメージング会年次大会 (2012)
  • Author(s): 梅谷啓二,ジェームズ ティー ピアーソン, ダリル オー シュウェンケ,白井幹康
  • Organizer: 2012 年映像情報メディア学会年次大会
  • Place of Presentation: 広島市立大学,広島県広島市
  • Year and Date: 2012-08-31
• [Presentation] 放射光での画像誘導放射線治療のための屈折コントラスト法による撮影 (2012)
  • Author(s): 梅谷啓二,近藤 威
  • Organizer: 第31回日本医用画像工学会大会
  • Place of Presentation: 札幌厚生病院,北海道札幌市
  • Year and Date: 2012-08-05
• [Presentation] 放射光を使ったX線生体顕微法による微小循環系の画像観察 (2012)
  • Author(s): 梅谷啓二,ジェームズ ティー ピアーソン,ダリル オー シュウェンケ,白井幹康
  • Organizer: 第51回日本生体医工学会大会
  • Place of Presentation: 福岡国際会議場,福岡県福岡市
  • Year and Date: 2012-05-10
• [Presentation] 前臨床試験のためのX線生体顕微法の開発 (2012)
  • Author(s): 梅谷啓二,James T. Pearson,Daryl O. Schwenke,白井幹康
  • Organizer: 第25回日本放射光学会年会・放射光科学合同シンポジウム
  • Place of Presentation: 鳥栖市民文化会館,佐賀県鳥栖市
  • Year and Date: 2012-01-08
• [Presentation] 放射光での画像誘導放射線治療のための屈折コントラスト法による撮影 (2012)
  • Author(s): 梅谷啓二、近藤 威
  • Organizer: 日本医用画像工学会大会
  • Place of Presentation: 札幌市
• [Presentation] 放射光を使ったＸ線生体顕微法による微小循環系の画像観察 (2012)
  • Author(s): 梅谷啓二、James T. Pearson、Daryl O. Schwenke、白井幹康
  • Organizer: 日本生体医工学会大会
  • Place of Presentation: 福岡市
• [Presentation] Development of synchrotron radiation X-ray intravital microscopy for in vivo imaging of rat heart vascular function (2011)
  • Author(s): Keiji Umetani, James T. Pearson, Daryl O. Schwenke, Mikiyasu Shirai
  • Organizer: 33rd Annual International Conference of the IEEE EMBS
  • Place of Presentation: Boston Marriott Copley Place, Boston, Massachusetts, USA
  • Year and Date: 2011-09-03
• [Presentation] Development of Synchrotron Radiation X-ray Intravital Microscopy for In Vivo Imaging of Rat Heart Vascular Function (2011)
  • Author(s): K.Umetani, J.T.Pearson, D.O.Schwenke, M.Shirai
  • Organizer: 33rd Annual International Conference of the IEEE EMBS
  • Place of Presentation: Boston, Massachusetts USA
  • Year and Date: 2011-09-03
• [Presentation] 画像誘導放射線治療での放射光屈折強調イメージングによる高精度化 (2011)
  • Author(s): 梅谷啓二,成山展照,近藤 威
  • Organizer: 2011 年映像情報メディア学会年次大会
  • Place of Presentation: 成蹊大学,東京都武蔵野市
  • Year and Date: 2011-08-26
• [Presentation] 放射光生体顕微鏡によるラット冠状動脈観察 (2011)
  • Author(s): 梅谷啓二,James T. Pearson,Daryl O. Schwenke,白井幹康
  • Organizer: 第30回日本医用画像工学会大会
  • Place of Presentation: 国際医療福祉大学,栃木県大田原市
  • Year and Date: 2011-08-05
• [Presentation] Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of the secondary pulmonary lobule (2011)
  • Author(s): Yoshiki Kawata, Takuya Hosokawa, Noboru Niki, Keiji Umetani, Yasutaka Nakano, Hironobu Ohmatsu, Noriyuki Moriyama, Harumi Itoh
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: Disney's Coronado Springs Resort, Orlando, Florida, USA
  • Year and Date: 2011-02-15
• [Presentation] マイクロビーム放射線治療のための高画質照射野確認画像 (2011)
  • Author(s): 梅谷啓二,成山展照,近藤 威,栗原 愛,福本 学,菓子野元郎,小野公二,丸橋 晃,田中浩基,篠原邦夫
  • Organizer: 第24回日本放射光学会年会・放射光科学合同シンポジウム
  • Place of Presentation: つくば国際会議場,茨城県つくば市
  • Year and Date: 2011-01-09
• [Presentation] Rat coronary microangiography system for preclinical imaging using synchrotron radiation (2010)
  • Author(s): Keiji Umetani, James T. Pearson, and Mikiyasu Shirai
  • Organizer: 2010 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Knoxville Convention Center,Knoxville, Tennessee, USA
  • Year and Date: 2010-11-06
• [Presentation] Rat Coronary Microangiography System for Preclinical Imaging Using Synchrotron Radiation (2010)
  • Author(s): Keiji Umetani, James T.Pearson, Mikiyasu Shirai
  • Organizer: 2010 IEEE Nuclear Science Symposium and Medical Imaging Conferenc
  • Place of Presentation: Knoxville, Tennessee, USA
  • Year and Date: 2010-11-05
• [Remarks] SPring-8 大型放射光施設、利用事例・研究成果
  • URL: http://www.spring8.or.jp/ja/science/
• [Remarks] SPring-8 大型放射光施設 メディカルバイオ利用事例
  • URL: http://www.spring8.or.jp/ja/science/medicalbio/
• [Remarks] SPring-8大型放射光施設、利用事例・研究成果
  • URL: http://www.spring8.or.jp/ja/science/