Preparation of retina-targeted siRNA delivery system possessing stability in blood
| Project/Area Number |
22500429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬物送達システム / siRNA / 核酸デリバリー / リポソーム / 網膜色素上皮細胞 / 網膜疾患 |
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| Research Abstract |
The transferrin(Trf)-modified liposomes which encapsulates nucleic acids such as siRNA and has stability in blood stream is developed for effective gene delivery to the posterior segment of eye (particularly retina) which has been known to be hard to deliver substances from blood stream. The results in vivo and in vitro study suggestthat the system is available as non-invasive application such as eye drop and could be added light- and thermo-activating function by improving components of lipids.
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Report
(4 results)
Research Products
(21 results)
