| Project/Area Number |
22500437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSUNOSE Kenya 徳島大学, 病院, 助教 (70507649)
TOMITA Noriko 徳島大学, 病院, 医員 (10533127)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心エコードプラ法 / 慢性心不全 / 僧帽弁口血流速波形 / 左室拡張末期圧 / 左室拡張不全 / 予後 / 下肢陽圧負荷心エコー検査 / 心不全 / 心エコー・ドプラ法 / 前負荷 / 負荷検査 / 左室拡張能 / 下肢陽圧負荷 |
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| Research Abstract |
Preload stress echocardiography was applied with leg-positive pressure (LPP) in patients with mild heart failure. Patients were classified into 3 groups based on transmitral flow velocity pattern: restrictive or pseudontrmal (PN) at rest, impaired relaxation (IR) at rest and during LPP (stable IR), and IR at rest and PN during LPP (unstable IR). All-cause cardiac event rate was higher in unstable IR than in stable IR, and was similar in PN group. Event-free survival was lower in unstable IR than stable IR. Preload stress echocardiography provides additional prognostic information in mild heart failure patients beyond conventional echocardiographic parameters.
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