| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We investigated whether the cardioprotective effects of edaravone and pifithrin were increased with ultrasound exposure. In addition, clinical research about early detection of anthracycline-induced cardiotoxicity was performed using left ventricular end-systolic wall stress-velocity of circumferential fiber shortening relationship (WS-Vcf relationship). Significant enhancement of the cardioprotective effects of these agents with ultrasound exposure was not seen. We plan the further investigation about the condition of ultrasound exposure. In the clinical research, WS-Vcf relationship was useful for the detection of the early anthracycline-induced cardiotoxicity.
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