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Experimental research to elucidate the pathogenesis and develop treatment for pain due to inactivity

Research Project

Project/Area Number 22500455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagoya University

Principal Investigator

SUZUKI Shigeyuki  名古屋大学, 医学系研究科(保健), 教授 (60179215)

Co-Investigator(Kenkyū-buntansha) 坂野 裕洋  日本福祉大学, 健康科学部, 准教授 (00351205)
Co-Investigator(Renkei-kenkyūsha) 岩田 全広  日本福祉大学, 健康科学部, 准教授 (60448264)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords疼痛 / 骨格筋 / ギプス固定 / 不活動 / ストレッチング
Research Abstract

As experimental research with the goal of elucidating the pathogenesis and developing treatments for pain due to inactivity, we created a rat model using cast immobilization of the hindlimbs to evaluate the relationship to pain and the influence of mechanical stimulation.Pain due to inactivity was evaluated as follows. Behavioral evaluation included measurement of painthresholds using the gastrocnemius muscle and measurement of the number of escape responses of hind foot pad. Histopathological evaluation included measuring the number of necrotic fibers in the gastrocnemius muscle. Molecular biological evaluation included RNA extraction and real-time polymerase chain reaction using specimens of the dorsal root ganglion and dorsal horn of the L4 -6 spinal cord.Results: A decreased pain threshold of gastrocunemius and increased number of escape responses of hind foot pad were observed immediately after immobilization, but these parameters tended to normalize early in the intervention group with mechanical stimulation. Histopathological evaluation showed marked muscle injury in the immobilization group compared to the intervention group. In addition, molecular biological evaluation showed higher expression of brain-derived neurotrophic factor mRNA in the dorsal horn in the immobilization group.These findings show that the development of pain is due to inactivity in both muscle and skin, and that BDNF mRNA expression plays a role in the pathogenesis of this pain.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (33 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (24 results) Book (2 results)

  • [Journal Article] 熱流速、総熱量測定による痛覚評価の検討2012

    • Author(s)
      下和広,鈴木重行,牛田享宏
    • Journal Title

      PAIN RESEARCH

      Volume: 27 Pages: 17-26

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アクティブIDストレッチングが筋機能に及ぼす影響2012

    • Author(s)
      中村浩一
    • Journal Title

      理学療法科学

      Volume: 27 Pages: 687-691

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性疼痛症候群と理学療法2011

    • Author(s)
      鈴木重行
    • Journal Title

      理学療法

      Volume: 28 Pages: 776-781

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 背部痛の理学療法 ‐評価と治療‐2011

    • Author(s)
      岩田全広,鈴木重行,他
    • Journal Title

      理学療法学

      Volume: 38 Pages: 631-632

    • NAID

      110008898348

    • Related Report
      2012 Final Research Report
  • [Journal Article] 背部痛の理学療法-評価と治療-2011

    • Author(s)
      岩田全広, 鈴木重行, 他
    • Journal Title

      理学療法学

      Volume: 38 Pages: 631-632

    • NAID

      110008898348

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Upregulation of P2X3 and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats2010

    • Author(s)
      HORI Kiyomi, OZAKI Noriyuki, SUZUKI Shigeyuki, SUGIURA Yasuo
    • Journal Title

      PAIN

      Volume: 149 Pages: 393-405

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] セラピューティック・ストレッチングの適応となる筋の病態生理学2010

    • Author(s)
      鈴木重行, 井上貴行, 坂野裕洋, 岩田全広, 松原貴子
    • Journal Title

      理学療法

      Volume: 27 Pages: 955-966

    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱刺激によるデキサメタゾン誘導性筋萎縮の進行抑制効果とheat shock protein 27の発現状況2011

    • Author(s)
      岩田全広, 鈴木重行, 他3名
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレッチング時間の違いが他動的トルク、筋力、可動性に与える影響2011

    • Author(s)
      松尾真吾, 鈴木重行, 他3名
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 立位時の床面前後移動における刺激伝導パターンに関する研究2011

    • Author(s)
      浅井友詞, 鈴木重行, 他4名
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Heat Shock on Dexamethasone-induced Muscle Atrophy in Cultured Skeletal Muscle Cells2011

    • Author(s)
      Tsuchida W, Suzuki S, et al
    • Organizer
      16^<th> World Congress for Physical Therapy
    • Place of Presentation
      Amsterdam
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Body weight support treadmill training improves maximum walking speed in persons with incomplete spinal cord injury2011

    • Author(s)
      Hasegwa T, Suzuki S, et al
    • Organizer
      16^<th> World Congress for Physical Therapy
    • Place of Presentation
      Amsterdam
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Relationship between gait and delayed onset muscle soreness following eccentric contraction of triceps surae muscle2011

    • Author(s)
      Banno Y, Suzuki S, et al
    • Organizer
      16^<th> World Congress for Physical Therapy
    • Place of Presentation
      Amsterdam
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of transcutaneous electrical muscle stimulation on glucose tolerance and insulin sensitivity in rats2011

    • Author(s)
      Watanabe H, Suzuki S, et al
    • Organizer
      16^<th> World Congress for Physical Therapy
    • Place of Presentation
      Amsterdam
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大腿骨近位部骨折術後患者の患肢荷重率と歩行能力の関連性について2011

    • Author(s)
      岩崎真美, 鈴木重行, 他9名
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酸性食塩水投与によって作製される疼痛モデル動物に対するトレッドミル運動の影響2011

    • Author(s)
      井上貴行, 林和寛, 犬飼菜海, 井本晶太, 鈴木重行
    • Organizer
      第4回痛みの理学療法研究会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋伸張時間の違いが静的トルク,動的トルク,可動性に与える影響2011

    • Author(s)
      松尾真吾, 鈴木重行, 岩田全広, 坂野裕洋, 井上貴行
    • Organizer
      第4回痛みの理学療法学研究会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ギプス固定モデルラットの腓腹筋における筋圧痛閾値の変化の検討2011

    • Author(s)
      井上貴行,鈴木重行,他 5 名
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 酸性食塩水投与によって作製される痛みモデル動物に対する運動介入の影響2011

    • Author(s)
      林和寛,鈴木重行,他 3 名
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 骨格筋経皮的電気刺激がラットのインスリン感受性に及ぼす影響2011

    • Author(s)
      渡辺裕之,鈴木重行,他 3 名
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 熱流束および総熱量を指標とした冷覚および痛覚の定量的感覚検査の試み2011

    • Author(s)
      下 和弘,鈴木重行
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮崎
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Relationship between gait and delayed onset muscle soreness following eccentric contraction of triceps surae muscle2011

    • Author(s)
      Banno Y, Suzuki S, et al
    • Organizer
      16thWorld Congress for Physical Therapy .
    • Place of Presentation
      Amsterdam
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of transcutaneous electrical muscle stimulation on glucose tolerance and insulin sensitivity in rats2011

    • Author(s)
      Watanabe H, Suzuki S, et al
    • Organizer
      16thWorld Congress for Physical Therapy
    • Place of Presentation
      Amsterdam
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱流束、総熱量測定による痛覚評価の検討2011

    • Author(s)
      下 和弘,鈴木重行,他 3 名
    • Organizer
      第33回日本疼痛学会
    • Place of Presentation
      松山
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 熱刺激によるデキサメタゾン誘導性筋萎縮の進行抑制効果と heat shock protein 27 の発現状況2011

    • Author(s)
      岩田全広,鈴木重行,他 3 名
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of ion channels in muscle hyperalgesia in a new rat model of chronic post-ischemia pain2010

    • Author(s)
      HORI K, OZAKI N, SUZIKI S, SUGIURA Y.
    • Organizer
      13th World Congress on pain
    • Place of Presentation
      モントリオール
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋伸張時間の違いが各種パラメータに与える影響を確認するための方法論の検討2010

    • Author(s)
      松尾真吾, 岩田全広, 鈴木重行
    • Organizer
      第6回日本ペインリリース研究会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱流束を指標としたQuantitative Sensory Testingによる痛覚閾値測定の試み2010

    • Author(s)
      下和弘, 鈴木重行
    • Organizer
      第6回日本ペインリリース研究会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経皮的電気刺激の繰り返しがラット骨格筋の糖取り込みに及ぼす影響2010

    • Author(s)
      渡辺裕之, 坂本圭, 鈴木重行
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 熱流束方式温冷覚閾値計を用いた痛覚閾値測定の試み2010

    • Author(s)
      下和弘, 鈴木重行, 松原貴子, 牛田享宏
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Treadmill exercise reverses mechanical hyperalgesia in acid-injected rats

    • Author(s)
      Kazuhiro Hayashi
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Mirano
    • Related Report
      2012 Annual Research Report
  • [Book] 理学療法診療ガイドライン第1 版(2011)2011

    • Author(s)
      鈴木重行,坂野裕洋,他
    • Publisher
      (社)日本理学療法士協会
    • Related Report
      2012 Final Research Report
  • [Book] 理学療法診療ガイドライン第1版(2011)2011

    • Author(s)
      鈴木重行, 坂野裕洋, 他
    • Total Pages
      1223
    • Publisher
      (社)日本理学療法士協会
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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