| Project/Area Number |
22500469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
|
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YAMANO Mariko 大阪府立大学, 総合リハビリテーション学部, 准教授 (80192409)
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| Co-Investigator(Kenkyū-buntansha) |
KOUZAI Hana 大阪府立大学, 総合リハビリテーション学部, 講師 (00382242)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | リハビリテーション医学 / 糖尿病モデル動物 / 運動療法 / オレキシン神経 / 糖尿病モデルマウス / 栄養療法 / 骨格筋 / 中枢効果 / 糖尿病マウス / 中枢神経 / 摂食中枢 / 神経活動 |
|---|
| Research Abstract |
The effects of exercise on hypothalamic orexin(OX) neurons were assessed in type 2 diabetic model mice. Orexin controls the feeding behavior as well as the arousal level. C-Fos expression in hyothalamic orexin neurons is decreased in db/db mice. We found that exercise by treadmill running (6 m/min, 30 min) for 4 days increased c-Fos expression in orexin neurons of both db/db and db/m mice. Orexin mRNA levels in the hypothalamus tended to be increased in EX groups of both db/db and db/m mice.
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