| Project/Area Number |
22500476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kitasato University |
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Principal Investigator |
SAKAMOTO Miki 北里大学, 医療衛生学部, 講師 (40365177)
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| Co-Investigator(Kenkyū-buntansha) |
岡 和之 東邦大学, 医学部, 准教授 (10120247)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | リハビリテーション医学 / 廃用性筋萎縮 / 走査型電子顕微鏡 / 骨格筋 / 筋膜 / 形態的変化 |
|---|
| Research Abstract |
This study analyzed the histological and ultrastructural changes of atrophied muscle fibers using scanning electron microscopy (SEM) and immunohistochemistry. We used an animal model of disused muscle atrophy. In muscle fibers of the immobilization group, wave-like structure was observed: it appeared as a groove, and was thought to be endomysium inserted into the cytoplasm of the muscle fiber. The wave-like structure was positive for anti-collagen IV antibody. Based on these results, the structure which inserted into the cytoplasm and formed a groove was confirmed to be endomysium. Moreover, myofibrillar disruption and MMP expression were not observed at region of the wave-like structure.
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