Investigation of neurochemical mechanism for the effect of trans-cranial direct current stimulation using multi-modal neuroimaging techniques
| Project/Area Number |
22500479
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | リハビリテーション医学 / ニューロリハビリテーション / 機能的近赤外線スペクトロスコピー / ドーパミンD2受容体 / 脳可塑性 / ポジトロンCT(PET) / ドーパミンD2 |
|---|
| Research Abstract |
we aimed to investigate the neurochemical mechanism for the effect of trans-cranial Direct Current Stimulation (t-DCS) using f-NIRS (functional near-infrared spectroscopy) combined with functional Magnetic Resonance Imaging (f-MRI) and Positron Emission Tomography (PET). We confirmed that the upper limb representation in primary motor area, referred to the international 10/20 system for EEG electrode placement, matched well with the motor map derived from f-MRI. Also, f-NIRS results demonstrated that the increase of [oxy-Hb] during a motor task (repetitive grip and release) was enhanced by anodal t-DCS effect, but after exposure to sulpiride, a dopamine D2 antagonist, the enhancement was interfered. The fact may suggest that the effect of t-DCS could be modulated by dopamine system. The findings might contribute to the improvement of t-DCS effect, in terms of its augmentation and persistency.
|
Report
(4 results)
Research Products
(28 results)
-
-
-
-
-
-
[Journal Article] Preparation of acute living hippocampal slice from commonmarmoset (Callithrix jacchus) for synaptic function analysis2012
Author(s)
Oh-Nishi, A. , Obayashi, S., T.Minamimoto, Y., Nagai, Y., Hori, T., Suhara
-
Journal Title
Neuroscience Research
Volume: 72(3)
Pages: 275-278
Related Report
-
-
-
[Journal Article] reparation of acute living hippocampal slice from common marmoset (Callithrix jacchus) for synaptic function analysis2012
Author(s)
Oh-Nishi, A. , Obayashi, S., T. Minamimoto, Y., Nagai, Y., Hori, T., Suhara
-
Journal Title
Neuroscience Research
Volume: 72(3)
Issue: 3
Pages: 275-278
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
