| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
we aimed to investigate the neurochemical mechanism for the effect of trans-cranial Direct Current Stimulation (t-DCS) using f-NIRS (functional near-infrared spectroscopy) combined with functional Magnetic Resonance Imaging (f-MRI) and Positron Emission Tomography (PET). We confirmed that the upper limb representation in primary motor area, referred to the international 10/20 system for EEG electrode placement, matched well with the motor map derived from f-MRI. Also, f-NIRS results demonstrated that the increase of [oxy-Hb] during a motor task (repetitive grip and release) was enhanced by anodal t-DCS effect, but after exposure to sulpiride, a dopamine D2 antagonist, the enhancement was interfered. The fact may suggest that the effect of t-DCS could be modulated by dopamine system. The findings might contribute to the improvement of t-DCS effect, in terms of its augmentation and persistency.
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