| Project/Area Number |
22500487
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Suzuka University of Medical Science |
|---|
Principal Investigator |
ASADA Keiji 鈴鹿医療科学大学, 保健衛生学部, 講師 (10440851)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAKI Miyako 奈良県立医科大学, 医学部, 特任教授 (00033358)
OBATA Koji 岐阜大学, 医学系研究科, 助教 (40378229)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 細胞 / メカニカルストレス / 神経 / カルシウムイオン / 伝達 / 骨芽細胞 / サテライト細胞 |
|---|
| Research Abstract |
The aim of the present study was to investigate the sensory mechanism from osteoblasts to sensory neurons in co-culture system using MS of osteoblasts. The result indicated that MS of the osteoblast elicited afferent P2X receptor-mediated purinergic transmission to sensory neurons in all stages of a mouse development. Ultrastructural observation of the contact between the neurite and the osteoblast supported this finding. This afferent transmission varied with aging. Satellite cells may have protective actions on sensory neurons and could modulate this transmission.
|
