Mechanismsforthedisusemuscleatrophy

• Project/Area Number: 22500497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: 独立行政法人労慟者健康福祉機構総合せき損センター (2012); Spinal Injuries Center (2010-2011)
• Principal Investigator: UETA Takayoshi 独立行政法人労働者健康福祉機構総合せき損センター, 研究部, 研究員 (00574138)
• Co-Investigator(Renkei-kenkyūsha): OHKAWA Yasuyuki 九州大学, 医学研究院, 准教授 (80448430) ; OKADA Seiji 九州大学, 医学研究院, 医学研究院 (30448435)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 筋萎縮 / 脊髄損傷 / エピジェネティクス / 廃用性筋萎縮 / トランスクリプトーム解析

Research Abstract

To address the mechanisms underlying muscle atrophy, we produced three different mouse atrophy models by disuse and denervation. In these models, transcriptome analysis reveled that the drastic changes of chromatin remodeling factors and cell cycle regulators were observed at the acute phase, indicating that muscle atrophy is the active rather than passive cellular responses. In addition, epigenetic regulation of the satellite cell is essential for the muscle regeneration after injury and atrophy.

Research Products

• [Journal Article] Subarachnoid-ubarachnoid bypass: a new surgical technique for posttraumatic syringomyelia (2013)
  • Author(s): Hayashi T, Ueta T, Kubo M, Maeda T, Shiba K.
  • Journal Title: J Neurosurg Spine Volume: 18(4) Pages: 382-7
• [Journal Article] Clinical relationship between cervical spinal canal stenosis and traumatic cervical spinal cord injury without major fracture or dislocation (2013)
  • Author(s): Takao T, Morishita Y, Okada S, Maeda T, Katoh F, Ueta T, Mori E, Yugue I, Kawano 0, Shiba K.
  • Journal Title: Eur Spine J. Volume: (in press)
• [Journal Article] Rate of Complications Among the Recipients of Intrathecal Baclofen Pump in Japan: A Multicenter Study (2012)
  • Author(s): Taira T, Ueta T, Katayama Y, Kimizuka M, Nemoto A, Mizusawa H, Liu M, Koito M, Hiro Y, Tanabe H.
  • Journal Title: Neuromodulation Volume: (in press)
• [Journal Article] Analysis of the risk factors for tracheostomy in traumatic cervical spinal cord injury (2012)
  • Author(s): Yugue I, Okada S, Ueta T, Maeda T, Mori E, Kawano 0, Takao T, Sakai H, Masuda M, Hayashi T, Morishita Y, Shiba K.
  • Journal Title: Spine Volume: 37(26)
• [Journal Article] Soft-tissue damage and segmental instability in adult patients with cervical spinal cord injury without major bone injury (2012)
  • Author(s): Maeda T, Ueta T, Mori E, Yugue I, Kawano 0, Takao T, Sakai H, Okada S, Shiba K
  • Journal Title: Spine Volume: 37(25)
• [Journal Article] Comparison of the amounts of canal encroachment between semisitting and supine position of computed tomography-myelography for vertebral fractures of the elderly involving the posterior vertebral wall. (2012)
  • Author(s): Hayashi T, Maeda T, Ueta T, Shiba K, Iwamoto Y.
  • Journal Title: Spine Volume: 37(19)
• [Journal Article] Age-related changes in osseous anatomy, alignment, and range of motion of the cervical spine. Part I: Radiographic data from over 1,200 asymptomatic subjects. (2012)
  • Author(s): Yukawa Y, Kato F, Suda K, Yamagata M, Ueta T.
  • Journal Title: Eur Spine J. Volume: 21(8) Pages: 1492-8
• [Journal Article] Normal morphology, age-related changes and abnormal findings of the cervical spine. Part II: Magnetic resonance imaging of over 1, 200 asymptomatic subjects. (2012)
  • Author(s): Kato F, Yukawa Y, Suda K, Yamagata M, Ueta T.
  • Journal Title: Eur Spine J. Volume: 21(8) Pages: 1499-507
• [Journal Article] Spinous process-splitting open pedicle screw fusion provides favorable results in patients with low back discomfort and pain compared to conventional open pedicle screw fixation over 1 year after surgery (2012)
  • Author(s): Mori E, Okada S, Ueta T, Itaru Y, Maeda T, Kawano 0, Shiba K.
  • Journal Title: Eur Spine J. Volume: 21(4) Pages: 745-53
• [Journal Article] Solitary epidural amyloidoma of C2-4 without osteolysis of the spine in a multiple myeloma patient (2012)
  • Author(s): Hayashi T, Shirasawa K, Maeda T, Ueta T, Shiba K, Iwamoto Y.
  • Journal Title: J Orthop Sci. Volume: 17(3) Pages: 319-22
• [Journal Article] Direct isolation and RNA祐eq reveal environment妖ependent properties of ngrafted neural stem/progenitor ells (2012)
  • Author(s): Kumamaru H, Ohkawa Y, Saiwai H, Yamada H, Kubota K, Kobayakawa K, Akashi K, Okano H, Iwamoto Y, Okada S.
  • Journal Title: Nat Commun Volume: 3 Pages: 1140-1140
• [Journal Article] Chd2 interacts with H3. 3 todetermine myogenic cell fate (2012)
  • Author(s): Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y
  • Journal Title: EMBO J. Volume: 31 Pages: 2994-3007
• [Journal Article] Soft tissue damage and segmental instability in adult patients with cervical spinal cord injury without major bone injury (2012)
  • Author(s): Maeda T, Ueta T, Mori E, Yugue I, Kawano O, Takao T, Sakai H, Okada S, Shiba K
  • Journal Title: Spine Volume: 37 Issue: 25 Pages: 1560-6
  • DOI: 10.1097/brs.0b013e318272f345
  • Peer Reviewed
• [Journal Article] Age-related changes in osseous anatomy, alignment, and range of motion of the cervical spine. Part I : Radiographic data from over 1,200 asymptomatic subjects. (2012)
  • Author(s): Yukawa Y, Kato F, Suda K, Yamagata M, Ueta T.
  • Journal Title: European Spine Journal Volume: 21 Issue: 8 Pages: 1492-8
  • DOI: 10.1007/s00586-012-2167-5
  • Peer Reviewed
• [Journal Article] Solitary epidural amyloidoma of C2-4 without osteolysis of the spine in a multiple myeloma patient. (2012)
  • Author(s): Hayashi T, Shirasawa K, Maeda T, Ueta T, Shiba K, Iwamoto Y.
  • Journal Title: Journal of orthopaedic science Volume: 17 Issue: 3 Pages: 319-22
  • DOI: 10.1007/s00776-011-0086-7
  • Peer Reviewed
• [Journal Article] Age-related changes in osseous anatomy, alignment, and range of motion of the cervical spine. Part I : Radiographic data from over 1,200 asymptomatic subjects (2012)
  • Author(s): Yukawa Y, Kato F, Suda K, Yamagata M, Ueta T
  • Journal Title: European Spine Journal Volume: (In press)
  • Peer Reviewed
• [Journal Article] Normal morphology, age-related changes and abnormal findings of the cervical spine. Part II : magnetic resonance imaging of over 1,200 asymptomatic subjects (2012)
  • Author(s): Kato F, Yukawa Y, Suda K, Yamagata M, Ueta T
  • Journal Title: European Spine Journal Volume: (In press)
  • Peer Reviewed
• [Journal Article] Spinous process-splitting open pedicle screw fusion provides favorable resuits in patients with low back discomfort and pain compared to conventional open pedicle screw fixation over 1 year after surgery (2012)
  • Author(s): Mori E, Okada S, Ueta T, Itaru Y, Maeda T, Kawano O, Shiba K
  • Journal Title: European Spine Journal Volume: 21 Pages: 745-53
  • Peer Reviewed
• [Journal Article] Analysis of the risk factors for severity of neurologic status in 216 patients with thoracolumbar and lumbar burst fractures (2011)
  • Author(s): Yugue I, Aono K, Shiba K, Ueta T, Maeda T, Mori E, Kawano 0.
  • Journal Title: Spine Volume: 36(19) Pages: 1563-9
  • NAID: 10030717288
• [Journal Article] Analysis of the risk factors for severity of neurological status in 216 patients with thoracolumbar and lumbar burst fractures. (2011)
  • Author(s): Yugue I, Aono K, Shiba K, Ueta T, Maeda T, Mori E, Kawano O.
  • Journal Title: Spine. Volume: (In press)
  • NAID: 10030717288
  • Peer Reviewed
• [Journal Article] Outcome of decompression surgery for cervical spinal cord injury without bone and disc injury in patients with spinal cord compression: a multicenter prospective study (2010)
  • Author(s): Kawano 0, Ueta T, Shiba K, Iwamoto Y.
  • Journal Title: Spinal Cord Volume: 48(7) Pages: 548-53
• [Journal Article] Outcome of decompression surgery for cervical spinal cord injury without bone and disc injury in patients with spinal cord compression : a multicenter prospective study. (2010)
  • Author(s): Kawano O, Ueta T, Shiba K, Iwamoto Y.
  • Journal Title: Spinal Cord. Volume: 48 Pages: 548-553
  • Peer Reviewed
• [Journal Article] 非骨傷性頸髄損傷の予防法と早期治療体系の確立に係わる研究・開発,普及:日本人の正常頸髄・硬膜管形態について (2010)
  • Author(s): 加藤文彦, 湯川泰紹, 須田浩太, 山縣正庸, 植田尊善
  • Journal Title: 日本職業・災害医学会会誌 Volume: 58 Pages: 52-64
  • NAID: 10029837924
  • Peer Reviewed
• [Presentation] 脊髄損傷の臨床 (2012)
  • Author(s): 植田尊善
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-06-01
• [Presentation] 脊髄損傷の治療 (2012)
  • Author(s): 植田尊善
  • Organizer: 第49回日本リハビリテーション医学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-06-01
• [Presentation] 脊椎脊髄損傷の臨床(本邦の疫学調査を中心) (2011)
  • Author(s): 植田尊善
  • Organizer: 第46回日本脊髄障害医学会
  • Place of Presentation: 関西国際会議場
  • Year and Date: 2011-11-19
• [Presentation] 脊髄脊髄損傷の臨床本邦の疫学調査を中心に (2011)
  • Author(s): 植田尊善
  • Organizer: 第46回日本脊髄障害医学会教育講演
  • Place of Presentation: 関西空港会議場
  • Year and Date: 2011-11-19
• [Presentation] 脊椎脊髄損傷の臨床一救急室から社会復帰、車椅子スポーツまでの実績一 (2010)
  • Author(s): 植田尊善
  • Organizer: 第326回九州大学整形外科Monthly Orthopaedic Conference
  • Place of Presentation: アクロス福岡国際議場
  • Year and Date: 2010-05-17
• [Presentation] 脊椎脊髄損傷の臨床-救急室から社会復帰、車椅子スポーツまでの実績- (2010)
  • Author(s): 植田尊善
  • Organizer: 第326回九州大学整形外科Monthly Orthopaedic Conference
  • Place of Presentation: アクロス福岡国際会議場(福岡)
  • Year and Date: 2010-05-17
• [Remarks]
  • URL: http://www.sekisonh.rofuku.go.jp/