oles of orexin neuron on the reward based spontaneous voluntary behavior

• Project/Area Number: 22500527
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical education
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: INOKAWA Hitoshi 京都府立医科大学, 医学研究科, 講師 (40285250)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 報酬 / 大脳基底核 / ドーパミン / オレキシン / アセチルコリン / 傍細胞記録 / 視床下部 / 黒質

Research Abstract

To understand the role of the striatum in value- and strategy-based decision-making and hypothalamic orexin neuron in reward based spontaneous ehavior, we recorded striatal and the orexin neurons in macaque monkeys and rats Large subsets of striatal neurons encoded positive and negative outcome feedbacks of individual decisions and actions. Juxtacellular recording was made in hypothalamic area and investigate orexin neuron by means of immunohistochemical method. This sample is presently being analyzed. These activity profiles as a heterogeneous representation of decision variables may underlie a part of the process for reinforcement- and strategy-based evaluation of selected actions in the striatum.

Research Products

• [Journal Article] Coding of the long-term value of multiple future rewards in the primate striatum (2013)
  • Author(s): Yamada H, Inokawa H, Matsumoto N, Ueda Y, Enomoto K, Kimura M
  • Journal Title: J Neurophysiol Volume: 109(4) Issue: 4 Pages: 1140-51
  • DOI: 10.1152/jn.00289.2012
  • Peer Reviewed
• [Journal Article] Neuronal basis for evaluating selected action in the primate striatum (2011)
  • Author(s): Yamada H, Inokawa H, Matsumoto N, Ueda Y, Kimura M
  • Journal Title: Eur J Neurosci. 2011 Aug Volume: 34 (3) Issue: 3 Pages: 489-506
  • DOI: 10.1111/j.1460-9568.2011.07771.x
  • Peer Reviewed
• [Presentation] カンナビノイド(CB1)受容体阻害剤の線条体注入による、試行錯誤学習課題に及ぼす影響 (2012)
  • Author(s): 岡崎哲、上田康雅、山中航、榎本一紀、井之川仁, 他4名
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野県松本市
  • Year and Date: 2012-03-31
• [Presentation] タスク戦略の適応転換における線条体アセチルコリン伝達の役割 (2010)
  • Author(s): 井之川仁
  • Organizer: 第33回日本神経科学学会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-03