Interaction of regular exercise and caloric restriction for the DNA repair system
| Project/Area Number |
22500607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | スポーツ生化学 / 運動 / カロリー制限 / DNA 修復システム / DNA修復酵素 / DNA酸化損傷 / 活性酸素種 / DNA修復 |
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| Research Abstract |
The purpose of this study was to investigate the interaction of low intensity regularexercise and 40% caloric restriction for DNA repair system. Oxidative stress level innuclear DNA was elevated by exercise or caloric restriction alone, and it disappearedby the combination of both. Additionally, a regular exercise itself markedly attenuatesoxidative damage in mitochondrial DNA, regardless of a caloric restriction. However,there were no significant changes in DNA repair enzyme expression by the 12-weekintervention. It is conceivable that the habitual low intensity exercise and caloricrestriction may not have an influence on the responsiveness of the enzyme expression ina DNA repair system.
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Report
(4 results)
Research Products
(6 results)
