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Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system

Research Project

Project/Area Number 22500609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionTottori University

Principal Investigator

MIYOSHI Michio  鳥取大学, 医学部, 助教 (20093627)

Co-Investigator(Kenkyū-buntansha) WATANABE Tatsuo  鳥取大学, 医学部, 教授 (60182929)
KOBA Satoshi  鳥取大学, 医学部, 講師 (40565743)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords運動とトレーニング / 慢性運動 / ストレス / 交感神経 / 高血圧 / トレーニング / ノルエピネフリン / SHRラット / 運動療法 / アドレナリン / ノルアドレナリン / 運動 / 糖尿病
Research Abstract

We investigated effects of 4-weeks’ running training on the increases in blood pressure (BP) and catecholamine levels induced by a novel stress (immobilization stress) in spontaneously hypertensive rats (SHR). The rats’ sensitivity to exogenously infused norepinephrine (NE) was investigated too. The present results suggest that the stress-induced activation of the sympathetic nervous system and the sensitivity to NE were each attenuated after 4-weeks’ running training, with a consequent reduction in the BP response to a novel stress.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (10 results) Remarks (3 results)

  • [Journal Article] Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II. American Journal of Physiology2013

    • Author(s)
      Koba, S., Watanabe, R., Kano, N. and Watanabe, T
    • Journal Title

      Heart and Circulatory Physiology

      Volume: 304 Issue: 1 Pages: H142-H153

    • DOI

      10.1152/ajpheart.00423.2012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise pressor reflex function in female rats fluctuates with the estrous cycle.2012

    • Author(s)
      Koba, S., Yoshinaga, K., Fujita, S., Miyoshi, M. and Watanabe, T.
    • Journal Title

      Journal of Applied Physiology

      Volume: 113(5) Issue: 5 Pages: 719-726

    • DOI

      10.1152/japplphysiol.00396.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans2012

    • Author(s)
      Fukada M., et al
    • Journal Title

      Chemical Senses

      Volume: 37 Issue: 4 Pages: 347-356

    • DOI

      10.1093/chemse/bjr108

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Green odor and depressive-like state in rats: Toward an evidence-based alternative medicine?2011

    • Author(s)
      Watanabe, T., Fujihara, M., Murakami, E., Miyoshi, M., Tanaka, Y., Koba, S. andTachibana, H.
    • Journal Title

      Behavioural Brain Res

      Volume: 224(2) Issue: 2 Pages: 290-296

    • DOI

      10.1016/j.bbr.2011.06.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of ginger against aspirin-induced gastric ulcers in rats.2011

    • Author(s)
      Wang, Z., Hasegawa, J., Wang, X.,Matsuda, A., Tokuda, T., Miura, N. and Watanabe, T.
    • Journal Title

      Yonago Acta medica

      Volume: 54 Pages: 11-19

    • NAID

      120002890329

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Green odor and depressive-like state in rats : Toward an evidence-based alternative medicine?2011

    • Author(s)
      Watanabe T., et al
    • Journal Title

      Behavioural Brain Research

      Volume: 224 Pages: 290-296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress in rats suppresses sweet and umami taste responses and lingual expression of T1R3 mRNA2010

    • Author(s)
      Okamoto, A., Miyoshi, M., Imoto, T., Ryoke, K., and Watanabe, T.
    • Journal Title

      Neuroscience Letters

      Volume: 486(3) Issue: 3 Pages: 211-214

    • DOI

      10.1016/j.neulet.2010.09.055

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Green odor inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring2010

    • Author(s)
      Fujita, S., Ueki, S., Miyoshi, M., and Watanabe, T.
    • Journal Title

      Hormones and Behav

      Volume: 58(2) Issue: 2 Pages: 264-272

    • DOI

      10.1016/j.yhbeh.2010.03.007

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats.2010

    • Author(s)
      Miyoshi, M. and Watanabe, T.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 109(1) Issue: 1 Pages: 49-57

    • DOI

      10.1007/s00421-009-1157-8

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring.2010

    • Author(s)
      Sayaka Fujita
    • Journal Title

      Hormones and Behavior

      Volume: 58(2) Pages: 264-272

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress in rats suppresses sweet and umami taste responses and lingual expression of T1R3 mRNA.2010

    • Author(s)
      Atsuhiro Okamoto
    • Journal Title

      Neuroscience Letters

      Volume: 486(3) Pages: 211-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 活動筋反射:運動骨格筋による交感神経刺激のメカニズム2013

    • Author(s)
      木場 智史
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] バラの香りを吸入するとストレスによる皮膚バリア障害が抑制される ~ラットとヒトを用いた検討~2013

    • Author(s)
      弓岡 英里、深田 美香、渡邊達生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 心筋梗塞ラットの運動トレーニングは中枢性交感神経賦活応答を抑制する2012

    • Author(s)
      木場 智史、井上 裕美子、久留 一郎、渡邊 達生
    • Organizer
      第64回日本生理学会中国四国地方会
    • Place of Presentation
      高知
    • Year and Date
      2012-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] うつ病に対する緑の香りの予防・治療効果について ~ラットを用いた検討~2012

    • Author(s)
      渡邊達生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 緑の香りはラットのうつ病様状態を緩和する2011

    • Author(s)
      橘広人、渡邊達生
    • Organizer
      第50回日本生気象学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] アンジオテンシンII由来高血圧ラットの活動筋反射は活性酸素によって増強される2011

    • Author(s)
      木場智史、渡辺亮介、狩野尚香、渡邊達生
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島
    • Year and Date
      2011-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 性周期は活動筋反射に影響する2010

    • Author(s)
      木場智史、吉永健嗣、藤田小矢香、渡邊達生
    • Organizer
      第62回日本生理学会中国四国地方会
    • Place of Presentation
      出雲
    • Year and Date
      2010-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 発熱とアンジオテンシンII ~炎症性サイトカイン産生促進作用について~2010

    • Author(s)
      渡邊達生
    • Organizer
      日本麻酔学会中国・四国支部第47回学術集会
    • Place of Presentation
      米子
    • Year and Date
      2010-09-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 妊娠ラットの香料吸入で胎生期ストレスによる仔の内分泌・行動異常を抑制できるか?2010

    • Author(s)
      藤田小矢香、上木史織、三好美智夫、渡邊達生
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 妊娠ラットの香料吸入で胎生期ストレスによる仔の内分泌・行動異常を抑制できるか?2010

    • Author(s)
      藤田小矢香
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民情報交流センター(盛岡市)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/intgphys/6005.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/intgphys/6005.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/1/3/4/5/9.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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