| Project/Area Number |
22500611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
TAMAKI Hiroyuki 新潟医療福祉大学, 医療技術学部, 教授 (40253926)
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| Co-Investigator(Kenkyū-buntansha) |
YOTANI Kengo 鹿屋体育大学, 体育学部, 助教 (10581142)
KIRIMOTO Hikari 新潟医療福祉大学, 医療技術学部, 准教授 (40406260)
ONISHI Hideaki 新潟医療福祉大学, 医療技術学部, 教授 (90339953)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨 / 運動 / 磁場 / メカニカルストレス / 骨格筋 / 老化 / 電気刺激 / コラーゲン / 遺伝子 / 筋細胞 |
|---|
| Research Abstract |
We examined the in vivo effects of repetitive pulsed magnetic stimulation (rPMS) and exercise training with mechanical stress on muscle and bone formation in young and aged rat. The rPMS stimulated mRNA levels of BMP-2 and TGF-β2 after 24 h of treatment compared to the contralateral hindlimb in young rats. In old rats, rPMS at higher intensity did not up-regulate mRNA expression levels of osteoblast marker genes. The beneficial effects of rPMS on gene expression levels related to bone formation may thus be associated with age and/or stimulation intensity.
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