Antidepressant and anxiolytic effects of physical exercise and brain plasticity
| Project/Area Number |
22500612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
KITA Ichiro 首都大学東京, 人間健康科学研究科, 教授 (10186223)
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| Co-Investigator(Kenkyū-buntansha) |
西島 壮 首都大学東京, 人間健康科学研究科, 助教 (10431678)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 行動神経科学 / 運動 / ストレス / うつ病 / 脳機能 / 免疫組織化学 / 運動条件 / うつ病モデル / 脳神経活動 / セロトニン神経 / CRF神経 / HPA軸 |
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| Research Abstract |
A great number of studies have suggested that physical exercise can reduce the incidence and symptoms of stress-related psychiatric disorders such as depression and anxiety through exercise-induced neuroplasticity, but the underlying neural mechanisms are not yet fully understood. In the present study, we examined how physical exercise mediates the stress-related psychiatric disorders, and considered the exercise parameters that result in the most favorable changes in brain plasticity. The results of this study suggested that physical exercise with less stress, such as mild or voluntary exercise, may be most efficient for preventing the incidence of stress-related psychiatric disorders.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS.2010
Author(s)
Nishijima T, Piriz J, Duflot S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Garcia Verdugo JM, Leroy F, Soya H, Nunes A, Torres-Aleman I.
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Journal Title
Neuron
Volume: 67
Pages: 834-846
Related Report
Peer Reviewed
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