Study on physical and mental fatigue using biomarkers in urine and brain.
Project/Area Number |
22500614
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Daito Bunka University |
Principal Investigator |
OSHIRO Satoru 大東文化大学, スポーツ・健康科学部, 教授 (30160485)
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Co-Investigator(Kenkyū-buntansha) |
YANASE Sumino 大東文化大学, スポーツ・健康科学部, 准教授 (90249061)
TAKAYAMA Shigenobu 大東文化大学, スポーツ・健康科学部, 教授 (50407657)
MORIOKA Masaki 東京大学, 医学部附属病院, 特任助教 (30351589)
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Research Collaborator |
IWASAWA Yuya 大東文化大学, スポーツ・健康科学研究科, 大学院生
SUGASAWA Takehito 大東文化大学, スポーツ・健康科学研究科, 大学院生
NISHIYAMA Nobuo 大東文化大学, スポーツ・健康科学研究科, 大学院生
UEDA Yasuhisa 大東文化大学, スポーツ・健康科学研究科, 大学院生
REN Jing 大東文化大学, スポーツ・健康科学研究科, 大学院生
SHIBUYA Takumi 大東文化大学, スポーツ・健康科学研究科, 大学院生
YOSHIKOSHI Chinatsu 大東文化大学, スポーツ・健康科学研究科, 大学院生
SUGA Naohiro 大東文化大学, スポーツ・健康科学研究科, 大学院生
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | スポーツ生化学 / 肉体疲労 / 精神疲労 / 疲労マーカー / 活性酸素 / 過酸化水素 / 疲労 / c-fos / RNA-seq / 神経科学 / DNA酸化物質8-OHdG / 概日リズム / 神経化学 |
Research Abstract |
It is said that approximately two thirds of working population in Japan may be tired of working. The study of fatigue makes a contribution to the quality of life of the people. In this study, to investigate the difference between physical and mental fatigue, and the degree of both fatigue, we examined these biomarkers. The analysis of urine from physical or mental stress-loaded experimental animals, rats suggests that hydrogen peroxide, a reactive oxygen species is at least a kind of biomarker for physical fatigue. We will also analyze marker proteins and gene expressions related to fatigue using RNA-seq of mRNA from rat brain.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Relation between Physical and Mental Fatigue in Urine Biomarker, Hydrogen Peroxide2011
Author(s)
Oshiro, S. Morioka M.S., Iwasawa,Y.,Ueda.Y.,Ren,J.,Yanase, S., Takayama, N
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Journal Title
J Neurochem(Supple.)
Volume: 118
Pages: 239-240
Related Report
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[Journal Article] Relation between physical and mental fatigue in urine biomarker, hydrogen peroxide2011
Author(s)
Oshiro, S., Morioka, M.S., Iwasawa, Y., Ueda, Y., Ren, J., Yanase, S., Takayama, S.
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Journal Title
Journal of Neurochemistry
Volume: 118
Pages: 239-240
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[Presentation] Studies on biomarkers for physical and mental fatigues2013
Author(s)
Sugasawa, T., Iwasawa, Y., Nishiyama,N., Morioka, M.S.,Takayama, S.,Yanase, S and Oshiro, S.
Organizer
第86回日本生化学会(発表予定)
Place of Presentation
パシフィコ横浜
Related Report
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[Presentation] Relation between physical and mental fatigue in urine biomarker, hydrogen peroxide2011
Author(s)
Oshiro, S., Morioka, M.S., Iwasawa, Y., Ueda, Y., Ren, J., Yanase, S., Takayama, S.
Organizer
The 23^<rd> Biennial meeting of international and European Society of Neurochemistry
Place of Presentation
Athens, Greece
Year and Date
2011-08-31
Related Report
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