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Relationships between lumber disc degeneration and genetic factors in athletes

Research Project

Project/Area Number 22500615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionNippon Sport Science University

Principal Investigator

HIRANUMA Kenji  日本体育大学, 大学院・体育科学研究科, 教授 (30434153)

Co-Investigator(Kenkyū-buntansha) 小山 浩司  東京有明医療大学, 保健医療学部, 講師 (70563469)
Co-Investigator(Renkei-kenkyūsha) 中里 浩一  日本体育大学, 体育学部, 教授 (00307993)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsスポーツ障害 / 椎間板変性 / 遺伝子 / 身体特性 / スポーツ / TGFbeta / CILP / アスポリン / 遺伝子多型
Research Abstract

In this study, we surveyed susceptible gene polymorphism for lumber disc degeneration (LDD). We also examined relationship between low back pain (LBP) and radiological abnormalities in lumber region. As a result, we found that COL11A1 gene polymorphism is susceptible for limbus vertebra (LV) in collegiate gymnasts. We also found the possibilities that LV eventually induce LDD. Furthermore, we found that significant association exists between LV and LBP in gymnasts. We finally developed a novel model for LBP occurrence concomitant with genetic polymorphism and radiological abnormalities.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Radiological Abnormalities and Low Back Pain in Gymnasts2013

    • Author(s)
      K. koyama, K. nzkazato, SK. Min, K. Gushiken, Y. Hatakeda, K. Seo, K. Hiranuma.
    • Journal Title

      Int J Sports Med

      Volume: 34巻 Pages: 218-222

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COL11A1 gene is associated with limbus vertebra in Gymnasts.2012

    • Author(s)
      Koyama K, Nakazato K, Min SK, Gushiken K, Hatakeda Y, Seo K, Hiranuma K.
    • Journal Title

      Int JSports Med.

      Volume: 33(7) Pages: 586-590

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lumbar disc degeneration : Clinical and genetic risk factors in athletes2011

    • Author(s)
      Min, et al
    • Journal Title

      J of Exer Nutr and Biochem

      Volume: 14(invited review) Pages: 113-130

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Cartilage intermediate layer protein gene is associated with lumbar disc degeneration in male, but not female collegiate athletes2011

    • Author(s)
      Min, et al
    • Journal Title

      Am J Sports Med

      Volume: 38[12] Pages: 2552-2557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lumbar disc degeneration:Clinical and genetic risk factors in athletes.2010

    • Author(s)
      Min SK, Koyama K, Hiranuma K, Nakazato K.
    • Journal Title

      The Korean journal of Exercise Nutrition. (Invited review)

      Volume: 14(3) Pages: 113-120

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cartilage Intermediate Layer Protein Gene is Associated With Lumbar Disc Degeneration in Male, but Not Female, Collegiate Athletes.2010

    • Author(s)
      Seok-ki min, koichi Nakazato, Yousuke Yamamoto, Kouji Gusiken, Hideo Fujishiro, Yuri Kobayakawa and Kenji Hiranuma
    • Journal Title

      Am J Sports Med

      Volume: 38(12) Pages: 2552-2557

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiological Abnormalities and Low Back Pain in Gymnasts.

    • Author(s)
      Koyama K,Nakazato K,Min SK,Gushiken K,Hatakeda Y, Seo K, Hiranuma K.
    • Journal Title

      Int JSports Med.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] COL11A1 Gene is Associated with Limbus Vertebrae in Gymnasts

    • Author(s)
      K.koyama, K.nzkazato, SK.Min, K.Gushiken, Y.Hatakeda, K.Seo, K.Hiranuma
    • Journal Title

      Int J Sports Med

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大学体操競技選手における胸腰椎画像異常所見とCOL11AI遺伝子多型の関連性2011

    • Author(s)
      小山浩司、中里浩一、閔石基、具志堅幸司、畠田好章、瀬尾京子、平沼憲治
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 大学体操競技選手における胸腰椎画像異常所見とCOL11A I遺伝子多型の関連性2011

    • Author(s)
      小山浩司、中里浩一、閔石基、具志堅幸司、畠田好章、瀬尾京子、平沼憲治
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cartilage intermediate layer prote in gene is associated with lumbar disc degen eration in male, but not female collegiate at hletes2011

    • Author(s)
      Min et al
    • Organizer
      The international Science Conference of Sport Actual problems of the development of physical culture and modern sports
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2011-04-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Cartilage intermediate layer protein gene is associated with lumbar disc degeneration in male, but not female collegiate athletes2011

    • Author(s)
      Min, et al
    • Organizer
      The international Science Conference of Sport Actual problems of the development of physical culture and modern sports.
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2011-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] スポーツ選手における椎間板変性の危険因子についてー身体特性および遺伝的な影響についてー2011

    • Author(s)
      平沼憲治
    • Organizer
      第242回北九州整形外科医会(特別講演)
    • Place of Presentation
      ステーションホテル小倉
    • Year and Date
      2011-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] スポーツ選手における椎間板変性の危険因子について-身体特性および遺伝的な影響について-2011

    • Author(s)
      平沼憲治
    • Organizer
      第242回北九州整形外科医会
    • Place of Presentation
      ステーションホテル小倉(特別講演)
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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