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Effect of Changes in Central Hemodynamics on the RespiratoryChemorelfex Feedback System Controlling Ventilation in Humans.

Research Project

Project/Area Number 22500617
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionMorinomiya University of Medical Sciences

Principal Investigator

MIYAMOTO Tadayoshi  森ノ宮医療大学, 大学院・保健医療学研究科, 教授 (40294136)

Co-Investigator(Kenkyū-buntansha) OGOH Shigehiko  東洋大学, 理工学部, 教授 (80553841)
NAKAHARA Hidehiro  森ノ宮医療大学, 大学院・保健医療学研究科, 講師 (90514000)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsシステム生理学 / 運動 / 呼吸調節 / 負帰還系 / 換気量 / 化学受容器反射 / 呼吸 / 生理学 / システム制御工学 / 循環調節 / 中心循環 / フィードバックシステム / 脳循環 / 呼吸器 / 循環器
Research Abstract

Although previous findings indicate that central blood volume (CBV) shift influences the respiratory regulation, the major regulatory mechanisms in the respiratory chemoreflex system which determine the operating arterial partial pressure of CO2 and minute ventilation responses to changes in CBV remain unclear. Using respiratory equilibrium diagram analysis, we evaluated the effect of CBV shift on the respiratory chemoreflex system divided into two subsystems: a controller (controlling system) and a plant (controlled system). Our findings first provide that CBV shift are related to the alteration in the properties of both controller and plant subsystems, and thus alter the operation mechanism of respiratory regulation under CBV shift. The equilibrium diagram analysis clearly indicates that resetting of the controller, rather than the plant, contributes predominantly to shift in the operating point under CBV shift.The respiratory controller resetting and/or plant dysfunction induced by CBV shift may be contributing to ventilatory abnormalities in CHF.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (62 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 19 results) Presentation (32 results) Book (5 results) Remarks (4 results)

  • [Journal Article] Cerebral hypoperfusion modifies the respiratory chemoreflex during orthostatic stress.2013

    • Author(s)
      Ogoh S, Nakahara H, Okazaki K, Bailey DM, Miyamoto T.
    • Journal Title

      Clin Sci.

      Volume: 125 Pages: 37-44

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries.2013

    • Author(s)
      Ogoh S, Sato K, Nakahara H, Okazaki K,Subudhi AW, Miyamoto T.
    • Journal Title

      Exp Physiol

      Volume: 98 Pages: 692-698

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manipulation of central blood volumeand implications for respiratorychemoreflex function.2013

    • Author(s)
      Miyamoto T. Bailey DM, Nakahara H, OgohS.
    • Journal Title

      Exp Physiol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral hypoperfusion modifies the respiratory cheraoreflex during orthostatic stress.2013

    • Author(s)
      Ogoh S, Nakahara H, Okazaki K, Bailey DM, Miyamoto T.
    • Journal Title

      Clinical Science

      Volume: 125 Pages: 37-44

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries.2013

    • Author(s)
      Ogoh S, Sato K, Nakahara H, Okazaki K, Subudhi AW, Miyamoto T.
    • Journal Title

      Experimental Physiology

      Volume: 98.(Epub 2012 Nov 9.) Issue: 3 Pages: 692-698

    • DOI

      10.1113/expphysiol.2012.068015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes.2012

    • Author(s)
      Miyamoto T, Inagak M, Takaki H, Kawada T,Shishido T, Kamiya A, Sugimachi M.
    • Journal Title

      Eur J Appl Physiol.

      Volume: 112 Pages: 237-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸化学調節系の運動適応機構-運動時換気亢進メカニズムのシステム的理解2012

    • Author(s)
      宮本忠吉
    • Journal Title

      森ノ宮医療大学紀要

      Volume: 3・4 Pages: 9-38

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes.2012

    • Author(s)
      Miyamoto T, Inagak M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 112(Epub 2011 May 3.) Pages: 237-251

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸化学調節系の運動適応機構-運動時換気亢進メカニズムのシステム的理解-2012

    • Author(s)
      宮本忠吉
    • Journal Title

      森ノ宮医療大学紀要

      Volume: 3,4 Pages: 9-38

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes2012

    • Author(s)
      Miyamoto T, Inagak M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M
    • Journal Title

      Eur J Appl Physiol

      Volume: 112 Pages: 237-251

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training augments the dynamic heart rate response to vagal but not sympathetic stimulation in rats.2011

    • Author(s)
      Mizuno M, Kawada T, Kamiya A, Miyamoto T,Shimizu S, Shishido T, Smith SA, SugimachiM.
    • Journal Title

      Am JPhysiol Regul Integr Comp Physiol.

      Volume: 300

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Physical Load while Propelling Manual Wheelchair on a Slope2011

    • Author(s)
      Hashizume T, Kitagawa H, Mohri T, Ueda H, Miyamoto T, Yoneda I, Fujisawa S
    • Journal Title

      Assistive Technology Research Series

      Volume: 29 Pages: 796-803

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of the respiratory controller contributes to the attenuation of exercise hyperpnea in endurance-trained athletes.2011

    • Author(s)
      Miyamoto T, Inagak M, Takaki H, Kawada T, Shishido T, Kamiya A, Sugimachi M.
    • Journal Title

      Eur J Appl Physiol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise training augments the dynamic heart rate response to vagal but not sympathetic stimulation in rats.2011

    • Author(s)
      Mizuno M, Kawada T, Kamiya A, Miyamoto T, Shimizu S, Shishido T, Smith SA, Sugimachi M.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 300 Pages: 969-977

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸循環制御の動作原理から見た慢性心不全病態の定量的理解.2010

    • Author(s)
      宮本忠吉,中原英博,宍戸稔聡,川田徹.
    • Journal Title

      第25回生体・生理工学シンポジウム論文集

      Pages: 229-232

    • Related Report
      2012 Final Research Report
  • [Journal Article] The effect of oxygen on dynamic cerebral autoregulation; critical role of hypocapnia.2010

    • Author(s)
      Ogoh S, Nakahara H, Ainslie PN, Miyamoto T.
    • Journal Title

      J Appl Physiol.

      Volume: 108 Pages: 538-543

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 低周波鍼通電刺激がヒトの心拍反応に及ぼす影響-再現性及び鍼刺入深度による影響の検討-2010

    • Author(s)
      中原英博, 川田徹, 山本裕美, 杉町勝, 宮本忠吉.
    • Journal Title

      循環制御

      Pages: 229-232

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic characteristics of heart rate control by the autonomic nervous system in rats.2010

    • Author(s)
      Mizuno M, Kawada T, Kamiya A, Miyamoto T, Shimizu S, Shishido T, Smith SA, Sugimachi M.
    • Journal Title

      Exp Physiol.

      Volume: 95 Pages: 919-925

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of oxygen on dynamic cerebral autoregulation ; critical role of hypocapnia.2010

    • Author(s)
      Ogoh S, Nakahara H, Ainslie PN, Miyamoto T.
    • Journal Title

      J Appl Physiol.

      Volume: 108 Pages: 538-543

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 短期間・低頻度の高強度持続的インターバルトレーニングが呼吸循環機能に及ぼす影響2010

    • Author(s)
      中原英博, 宮本忠吉.
    • Journal Title

      第25回生体・生理工学シンポジウム論文集

      Pages: 117-120

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 呼吸循環制御の動作原理から見た慢性心不全病態の定量的理解2010

    • Author(s)
      宮本忠吉, 中原英博, 宍戸稔聡, 川田徹
    • Journal Title

      第25回生体・生理工学シンポジウム論文集

      Pages: 229-232

    • Related Report
      2010 Annual Research Report
  • [Presentation] Distribution of blood flows toward head during whole body heating.2013

    • Author(s)
      Shibasaki M, Sato K, Okazaki K, Miyamoto T, Hirasawa A, Ogoh S.
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston-USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of cerebral blood flow on central chemoreflex during orthstatic stress.2012

    • Author(s)
      Ogoh S, Nakahara H, Okazaki K, Miyamoto T.
    • Organizer
      AMERICAN COLLEGE OF SPORTS MEDICINE ANNUAL MEETING, San Francisco
    • Place of Presentation
      California-USA
    • Related Report
      2012 Final Research Report
  • [Presentation] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function.2012

    • Author(s)
      Saku K, Hosokawa K, Sakamoto T Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K.
    • Organizer
      AMERICAN HEART ASSOCIATION CONFERENCE,Washington
    • Place of Presentation
      D. C-USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Central chemoreflex activation resets the setpoint pressure of baroreflex without compromising its function.2012

    • Author(s)
      Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Ide T,Miyamoto T, Sunagawa K.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego-USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 中心循環血液量の変化が呼吸調節機序に及ぼす影響.2012

    • Author(s)
      宮本忠吉,中原英博,上田真也,小河繁彦.
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Effect of changes in central hemodynamics on the Respiratory chemoreflex system controlling ventilation in humans.2012

    • Author(s)
      Miyamoto. T, Nakahara H.
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Blood flow response to carbon dioxide in human internal and external carotid arteries during hyperthermic condition.2012

    • Author(s)
      Ogoh S, Kohei Sato K, Hirasawa A, Okazaki, Miyamoto T, Shibasaki M
    • Organizer
      The second International Conference on Cerebral Autoregulation. Nijmegen
    • Place of Presentation
      The Netherlands
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of cerebral blood flow on central chemoreflex during orthstatic stress.2012

    • Author(s)
      Ogoh S, Nakahara H, Okazaki K, Miyamoto T.
    • Organizer
      AMERICAN COLLEGE OF SPORTS MEDICINE
    • Place of Presentation
      San Francisco, California-USA,
    • Related Report
      2012 Annual Research Report
  • [Presentation] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function.2012

    • Author(s)
      Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K.
    • Organizer
      AMERICAN HEART ASSOCIATION CONFERENCE,
    • Place of Presentation
      Washington, D. C-USA.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Central chemoreflex activation resets the setpoint pressure of baroreflex without compromising its function.2012

    • Author(s)
      Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Ide T, Miyamoto T, Sunagawa K.
    • Organizer
      Experimental Biology,
    • Place of Presentation
      San Diego-USA,
    • Related Report
      2012 Annual Research Report
  • [Presentation] フェニレフリン投与が外頸動脈血流量に及ぼす影響.2012

    • Author(s)
      小河繁彦, 佐藤耕平, 岡崎和伸, 宮本忠吉
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低酸素環境下での二酸化炭素分圧に対する脳血流反応.2012

    • Author(s)
      小河繁彦、中原英博、宮本忠吉.
    • Organizer
      第26回呼吸研究会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中心循環血液量の変化が呼吸化学調節系の動作点決定機序に及ぼす影響2012

    • Author(s)
      宮本忠吉, 川田徹, 杉町勝.
    • Organizer
      第13回Neurocardiology Workshop
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中枢呼吸化学受容器反射は動脈圧受容器反射の血圧安定化機能を変えることなく交感神経活動を修飾する2012

    • Author(s)
      朔啓太, 細川和也, 坂本隆史, 鬼塚健, 戸伏倫之, 坂本和生, 藤野剛雄, 柿野貴盛, 池田昌隆, 井手友美, 宮本忠吉, 砂川賢二.
    • Organizer
      第13回Neurocardiology Workshop
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中枢呼吸化学受容器反射は動脈圧受容器反射のリセツティングを介して交感神経活動を修飾する.2012

    • Author(s)
      朔啓太, 細川和也, 坂本隆史, 鬼塚健, 戸伏倫之, 坂本和生, 藤野剛雄, 柿野貴盛, 池田昌隆, 井手友美, 宮本忠吉, 砂川賢二
    • Organizer
      第33回日本循環制御医学会総会
    • Place of Presentation
      栃木
    • Related Report
      2012 Annual Research Report
  • [Presentation] 暑熱負荷時の脳血流量分配.2012

    • Author(s)
      芝崎学、佐藤耕平、岡崎和伸、宮本忠吉、小河繁彦.
    • Organizer
      温熱生理研究会
    • Place of Presentation
      愛知
    • Related Report
      2012 Annual Research Report
  • [Presentation] 暑熱負荷時における二酸化炭素分圧(PCO2)変化に対する外・内頸動脈血流反応.2012

    • Author(s)
      平澤愛, 佐藤耕平, 岡崎和伸, 宮本忠吉, 小河繁彦, 芝崎学
    • Organizer
      第51回日本生気象学会
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] 暑熱負荷における脳血流量低下に対する外頸動脈血流量の関係性.2012

    • Author(s)
      佐藤耕平, 平澤愛, 岡崎和伸, 宮本忠吉, 小河繁彦, 芝崎学
    • Organizer
      第51回日本生気象学会
    • Place of Presentation
      長野
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemoreflex activation markedly increases sympathetic nerve activity without changing baroreflex function in stabilizing arterial pressure against pressure disturbances2012

    • Author(s)
      Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K
    • Organizer
      FASEB
    • Place of Presentation
      USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Changes in Central Hymodynamics on the Respiratory Chemoreflex System Controlling Centilation in Humans2012

    • Author(s)
      Miyamoto T., Nakahara H
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] Feed-forward mechanism by central command during pre-exercise preparatory Period Plays a significant role in enhancing cardio-respiratory performance to dynamic exercise.2011

    • Author(s)
      Miyamoto. T, Nakahara H.
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 低頻度・高強度インターバルトレーニングが呼吸化学調節系の換気決定機構に及ぼす影響2011

    • Author(s)
      宮本忠吉, 中原英博
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低頻度・高強度インターバルトレーニングが漸増負荷運動時の呼吸循環動態に及ぼす影響2011

    • Author(s)
      中原英博, 宮本忠吉
    • Organizer
      第66回日本体力医学会
    • Place of Presentation
      下関
    • Related Report
      2011 Annual Research Report
  • [Presentation] Feed-Forward Mechanism by Central Command during Pre-Exercise Preparatory Period Plays a Significant Role in Enhancing Cardio-Respiratory Performance to Dynamic Exercise2011

    • Author(s)
      Miyamoto T., Nakahara H
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Aerobic Interval Exercise Training Attenuates the Respiratory Drive during Heavy Exercise through Desensitization of the Respiratory Central Controller2011

    • Author(s)
      Miyamoto T., Nakahara H
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 呼吸・循環系のシステム同定とその応用2011

    • Author(s)
      宮本忠吉
    • Organizer
      基礎体力研究所研究セミナー
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 呼吸循環制御の動作原理から見た慢性心不全病態の定量的理解.2010

    • Author(s)
      宮本忠吉
    • Organizer
      生体・生理工学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 運動時における呼吸化学調節系の動作原理の解明-システム生理学的アプローチの重要性-2010

    • Author(s)
      宮本忠吉
    • Organizer
      大阪大学バイオメックフォーラム21研究会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動的運動に対する呼吸循環系の見込み応答2010

    • Author(s)
      中西康弘, 中原英博, 外林大輔, 宮本忠吉
    • Organizer
      第25回生体生理工学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低頻度・超高強度持続的インターバルトレーニンダは呼吸循環機能を向上させる2010

    • Author(s)
      中原英博, 宮本忠吉
    • Organizer
      第25回生体生理工学シンポジウム
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低頻度の全力インターバルトレーニングが呼吸循環機能に及ぼす影響2010

    • Author(s)
      中原英博, 宮本忠吉
    • Organizer
      第65回日本体力医学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高位中枢による予測的・見込み的な呼吸循環制御の運動生理学的意義2010

    • Author(s)
      宮本忠吉、外林大輔、中西康人、中原英博
    • Organizer
      第65回日本体力医学会
    • Place of Presentation
      千葉
    • Related Report
      2010 Annual Research Report
  • [Book] フローチャートで学ぶ運動生理学実習.2012

    • Publisher
      建帛社
    • Related Report
      2012 Final Research Report
  • [Book] 身体運動と呼吸・循環機能-呼吸調節のシステム-2012

    • Publisher
      真興交易(株)医書
    • Related Report
      2012 Final Research Report
  • [Book] 特集呼吸器の救急救命治療,呼吸循環系の動作原理:The Lung perspectives.2012

    • Publisher
      MEDICAL R E VIEW社
    • Related Report
      2012 Final Research Report
  • [Book] 身体運動と呼吸・循環機能 -呼吸調節のシステム-2012

    • Author(s)
      宮本忠吉
    • Publisher
      宮村実晴編著、真興交易(株)医書出版部
    • Related Report
      2012 Annual Research Report
  • [Book] 特集呼吸器の救急救命治療,呼吸循環系の動作原理2012

    • Author(s)
      宮本忠吉
    • Total Pages
      104
    • Publisher
      The Lung perspectives. MEDICAL REVIEW社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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