Effect of Changes in Central Hemodynamics on the RespiratoryChemorelfex Feedback System Controlling Ventilation in Humans.
| Project/Area Number |
22500617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Morinomiya University of Medical Sciences |
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Principal Investigator |
MIYAMOTO Tadayoshi 森ノ宮医療大学, 大学院・保健医療学研究科, 教授 (40294136)
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| Co-Investigator(Kenkyū-buntansha) |
OGOH Shigehiko 東洋大学, 理工学部, 教授 (80553841)
NAKAHARA Hidehiro 森ノ宮医療大学, 大学院・保健医療学研究科, 講師 (90514000)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | システム生理学 / 運動 / 呼吸調節 / 負帰還系 / 換気量 / 化学受容器反射 / 呼吸 / 生理学 / システム制御工学 / 循環調節 / 中心循環 / フィードバックシステム / 脳循環 / 呼吸器 / 循環器 |
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| Research Abstract |
Although previous findings indicate that central blood volume (CBV) shift influences the respiratory regulation, the major regulatory mechanisms in the respiratory chemoreflex system which determine the operating arterial partial pressure of CO2 and minute ventilation responses to changes in CBV remain unclear. Using respiratory equilibrium diagram analysis, we evaluated the effect of CBV shift on the respiratory chemoreflex system divided into two subsystems: a controller (controlling system) and a plant (controlled system). Our findings first provide that CBV shift are related to the alteration in the properties of both controller and plant subsystems, and thus alter the operation mechanism of respiratory regulation under CBV shift. The equilibrium diagram analysis clearly indicates that resetting of the controller, rather than the plant, contributes predominantly to shift in the operating point under CBV shift.The respiratory controller resetting and/or plant dysfunction induced by CBV shift may be contributing to ventilatory abnormalities in CHF.
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Report
(4 results)
Research Products
(62 results)
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[Presentation] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function.2012
Author(s)
Saku K, Hosokawa K, Sakamoto T Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K.
Organizer
AMERICAN HEART ASSOCIATION CONFERENCE,Washington
Place of Presentation
D. C-USA
Related Report
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[Presentation] The central chemoreflex activation induces sympathoexcitation and resets the arterial baroreflex without compromising its pressure stabilizing function.2012
Author(s)
Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K.
Organizer
AMERICAN HEART ASSOCIATION CONFERENCE,
Place of Presentation
Washington, D. C-USA.
Related Report
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[Presentation] Central chemoreflex activation resets the setpoint pressure of baroreflex without compromising its function.2012
Author(s)
Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Ide T, Miyamoto T, Sunagawa K.
Organizer
Experimental Biology,
Place of Presentation
San Diego-USA,
Related Report
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[Presentation] 中枢呼吸化学受容器反射は動脈圧受容器反射の血圧安定化機能を変えることなく交感神経活動を修飾する2012
Author(s)
朔啓太, 細川和也, 坂本隆史, 鬼塚健, 戸伏倫之, 坂本和生, 藤野剛雄, 柿野貴盛, 池田昌隆, 井手友美, 宮本忠吉, 砂川賢二.
Organizer
第13回Neurocardiology Workshop
Place of Presentation
東京
Related Report
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[Presentation] 中枢呼吸化学受容器反射は動脈圧受容器反射のリセツティングを介して交感神経活動を修飾する.2012
Author(s)
朔啓太, 細川和也, 坂本隆史, 鬼塚健, 戸伏倫之, 坂本和生, 藤野剛雄, 柿野貴盛, 池田昌隆, 井手友美, 宮本忠吉, 砂川賢二
Organizer
第33回日本循環制御医学会総会
Place of Presentation
栃木
Related Report
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[Presentation] Chemoreflex activation markedly increases sympathetic nerve activity without changing baroreflex function in stabilizing arterial pressure against pressure disturbances2012
Author(s)
Saku K, Hosokawa K, Sakamoto T, Onitsuka K, Sakamoto K, Tobushi T, Fujino T, Kakino T, Ikeda M, Miyamoto T, Ide T, Sunagawa K
Organizer
FASEB
Place of Presentation
USA
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