| Project/Area Number |
22500618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Fukuoka University |
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Principal Investigator |
HIGAKI Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hiroaki 福岡大学, スポーツ科学部, 教授 (00078544)
KIYONAGA Akira 福岡大学, スポーツ科学部, 教授 (70177955)
TOBINA Takuro 長崎県立大学, 看護栄養学部, 講師 (60509678)
SUDO Mizuki 福岡大学, 身体活動研究所, ポストドクター (10585186)
ANDO Soichi 福岡大学, スポーツ科学部, 助教 (50535630)
山田 陽介 福岡大学, グローバルFUプログラム, ポストドクター (60550118)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 一酸化窒素合成酵素 / エピジェネティクス / メチル化 / トレーニング / 一酸化窒素 / 不活動 / 萎縮 / 一過性の運動 |
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| Research Abstract |
Rat skeletal muscle expresses NO synthase and that activity varies among several muscles. We hypothesized that NO as one of reactive oxygen intermediates modulates skeletal muscle glucose transport. First, we tried to make available methods for the model of training and inactivity in mice. Next, to determine if an epigenetic modification of NOS gene involves in mediating glucose transport in skeletal muscle, methylation of cytosines at CpG sites in promoter region of NOS gene was analyzed in these samples. Our results demonstrate that DNA methylation of the NOS promoter may be involved in the regulation of glucose metabolism in skeletal muscle.
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