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To elucidate effects of a low-protein diet under molecular levels, aiming at constructing the nutrition education.

Research Project

Project/Area Number 22500650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKagoshima Prefectural College

Principal Investigator

ARIMURA Emi  鹿児島県立短期大学, 生活科学科, 助教 (40552964)

Co-Investigator(Kenkyū-buntansha) HORIUCHI Masahisa  鹿児島大学, 医歯(薬)学総合研究科, 教授 (50264403)
Co-Investigator(Renkei-kenkyūsha) KAWAGUCHI Hiroaki  鹿児島大学, 獣医学部, 准教授 (60325777)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords栄養指導 / 食事療法 / 糖尿病 / 糖尿病腎症 / 食事たんぱく質 / 動物モデル / インスリン分泌不全 / レプチン受容体
Research Abstract

Patients with diabetic nephropathy (DN) is increased remarkably, leading to the increased number of patients with dialysis as a primary cause. Diet therapy for diabetes is high-protein diet, leading to restriction of carbohydrate. Thus, the increased numbers of DN might be related to the diet therapy. We examined how dietary protein contents affect renal manifestations and glucose levels under diabetes conditions. Under the same contentof energy and fat, a diet composed of low-protein and high-carbohydrate improved more on not only the renal manifestations but also the carbohydrate metabolism, compared to a diet composed of high-protein and low-carbohydrate.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Products Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice2013

    • Author(s)
      Emi Arimura、Masahisa Horiuchi、Hiroaki Kawaguchi、Noriaki Miyoshi、Kohji Aoyama、Toru Takeuchi
    • Journal Title

      European Journal of Nutrition

      Volume: Vol.52(2) Issue: 2 Pages: 813-824

    • DOI

      10.1007/s00394-012-0387-4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acupucture improves sleep conditions of minipigs representing diurnalanimals through an anatomically similar point to the acupoint(GV20)effective for humans2012

    • Author(s)
      Ka-ihiro Takeishi、Masahisa Horiuchi、 Hiroaki Kawaguchi、Yoshiki Deguchi、 Hiroyuki Izumi、Emi Arimura、SatoshiKuchiwa、Akihide Tanimoto、Toru Takeuchi
    • Journal Title

      Evidence-Based Complementaryand Alternative Medicine

      Volume: 2012 Pages: 472982-472982

    • DOI

      10.1155/2012/472982

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice2011

    • Author(s)
      Haruko Takeshita、Masahisa Horiuchi、Kimiko Izumo、Hiroaki Kawaguchi、Emi Arimura、 Kohji Aoyama、Toru Takeuchi
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: Vol.17(4) Issue: 4 Pages: 275-284

    • DOI

      10.1007/s12199-011-0249-3

    • NAID

      10030945703

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice

    • Author(s)
      Emi Arimura, Masahisa Horiuchi, Hiroaki Kawaguchi, Noriaki Miyoshi Kohji Aoyama, Toru Takeuchi
    • Journal Title

      European Journal of Nutrition

    • Description
      in press
    • Related Report
      Products Report
    • Peer Reviewed
  • [Presentation] Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice2012

    • Author(s)
      Emi Arimura
    • Organizer
      4th Scientific Meeting of theAsian Association for the Studyof Diabetes
    • Place of Presentation
      Kyoto International Conference Center(京都府)
    • Year and Date
      2012-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 食事療法の意義~合併症発症・進展予防へ向けて~、第27 回糖尿病合併症学会2012

    • Author(s)
      有村恵美
    • Organizer
      第18回日本糖尿病眼学会総会合同学会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 低たんぱく食が 2 型糖尿病の糖代謝・腎機能に及ぼす影響について2012

    • Author(s)
      有村恵美
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 低たんぱく食が2型糖尿病の糖代謝・腎機能に及ぼす影響について2012

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低たんぱく食が2型糖尿病の糖代謝・腎機能に及ぼす影響:dbマウスを用いた解析2012

    • Author(s)
      有村恵美
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-01-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 低たんぱく食が2型糖尿病の糖代謝・腎機能に及ぼす影響:dbマウスを用いた解析2012

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第14回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2012-01-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食事療法の意義~合併症発症・進展予防へ向けて~2012

    • Author(s)
      有村恵美
    • Organizer
      第27回日本糖尿病合併症学会・第18回日本糖尿病眼学会総会合同学会
    • Place of Presentation
      アクロス福岡(福岡県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice2012

    • Author(s)
      Emi Arimura
    • Organizer
      4th Scientific Meeting of the Asian Association for the Study of Diabetes
    • Place of Presentation
      Kyoto International Conference Center(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低蛋白食が 2 型糖尿病の糖代謝・腎機能に及ぼす影響について2011

    • Author(s)
      有村恵美
    • Organizer
      第23回日本糖尿病性腎症研究会
    • Place of Presentation
      ベルサーチ神田(東京都)
    • Year and Date
      2011-12-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 低蛋白食が2型糖尿病の糖代謝・腎機能に及ぼす影響について2011

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第23回日本糖尿病性腎症研究会
    • Place of Presentation
      ベルサーチ神田(東京都)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質摂取量と腎機能・糖 代謝の関わり:dbマウス(2型糖尿病モデル)を用いた解析2011

    • Author(s)
      有村恵美
    • Organizer
      第14回日本病態栄養学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-01-16
    • Related Report
      2012 Final Research Report
  • [Presentation] タンパク質摂取量と腎機能・糖代謝の関わり:dbマウス(2型糖尿病モデル)を用いた解析2011

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)(招待講演)
    • Year and Date
      2011-01-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛋白質量が 2 型糖尿病腎症発 症・進展に及ぼす影響:マウスモデル確立と機序解明2010

    • Author(s)
      有村恵美
    • Organizer
      第22回日本糖尿病性腎症研究会
    • Place of Presentation
      東京慈恵医科大学(東京都)
    • Year and Date
      2010-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛋白質量が2型糖尿病腎症発症・進展に及ぼす影響:マウスモデル確立と機序解明2010

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第22回日本糖尿病性腎症研究会
    • Place of Presentation
      東京慈恵医科大学(東京都)
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食事タンパク質量が 2 型糖尿病腎症発症・進展に及ぼす影響:マウスモデル確立と機序解明2010

    • Author(s)
      有村恵美
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 食事タンパク質量が2型糖尿病腎症発症・進農に及ぼす影響:マウスモデル確立と機序解明2010

    • Author(s)
      有村恵美, 堀内正久
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.k-kentan.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.k-kentan.ac.jp/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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