Large-scale longitudinal cohort study for the evaluation of genetic polymorphisms on the risk of lifestyle related diseases and applied prevention.

• Project/Area Number: 22500657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Chiba University
• Principal Investigator: WATANABE Miyuki 千葉大学, 大学院・医学研究院, 技術職員 (70571355)
• Co-Investigator(Kenkyū-buntansha): SUWAZONO Yasushi 千葉大学, 大学院・医学研究院, 准教授 (90302546) ; UETANI Mirei 千葉大学, 大学院・医学研究院, 講師 (30376371) ; NOGAWA Kazuhiro 千葉大学, 大学院・医学研究院, 助教 (00612194)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 生活習慣病 / 遺伝子多型 / 高血圧 / 高脂血症 / 糖尿病 / 大規模縦断追跡研究 / 追跡調査

Research Abstract

The aim of this study was to evaluate the risk for lifestyle related diseases and applied prevention based on genetic polymorphism in a large-scale longitudinal cohort study. This study suggested that the genetic polymorphisms for estrogen receptor(XbaI: rs9340799、PvuII: rs2234693) are associated with the risk for the hypertension, low serum HDL level and high serum γ-GTP level.