| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
To elucidate the possible role of glycogen synthase kinase 3β (GSK-3β) in sarcopenia, we investigated the relationship between its phosphorylation levels and the differentiation potential of satellite cells in vitro. The level of phosphorylation of GSK-3β was slightly decreased in satellite cells derived from old mice compared with adult mice. No significant difference in differentiation potential was observed between old and adult satellite cells, suggesting that satellite cells retain sufficient capacity to myogenic differentiation, irrespective of ageing. Additionally, we investigated whether inhibition of GSK-3β activity by lithium promote cell differentiation. This treatment almost equally accelerated myotube formation in both old and adult satellite cells. Taken together, inhibition of GSK-3β may contribute toattenuate age-related decline in skeletal muscle mass.
|
