| Project/Area Number |
22500660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Aichi University of Education |
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Principal Investigator |
SUZUKI Hideki 愛知教育大学, 教育学部, 教授 (40235990)
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| Co-Investigator(Kenkyū-buntansha) |
IMAIZUMI Kazuhiko 早稲田大学, 人間科学学術院, 教授 (60145068)
TSUJIMOTO Hisaya 久留米大学, 健康スポーツセンター, 教授 (70299519)
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| Co-Investigator(Renkei-kenkyūsha) |
TACHIYASHIKI Kaoru 上越教育大学, 副学長 (20119324)
SHIRATO Ken 早稲田大学, 人間科学学術院, 助手 (60559384)
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| Research Collaborator |
SATO Shogo 杏林大学, 医学部, 博士研究員
MITSUHASHI Ryosuke 早稲田大学, 人間科学研究科, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | クレンブテロール / ギプス固定 / β2 アドレナリン受容体 / 骨格筋 / β2アドレナリン受容体 / 筋委縮 / 筋萎縮 |
|---|
| Research Abstract |
The β2-agonist clenbuterol increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation. This study was to investigate the effect of clenbuterol administration on immobilization atrophy in rat skeletal muscle. The findings of the present study showed that clenbuterol attenuated the decrease in muscle mass and single fiber cross-sectional area in the extensor digitorum longus muscle, but did not in soleus muscle. These results suggested that antiatrophic effects are specific for the fast-twitch muscle on the immobilization atrophy in rat skeletal muscle.
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