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A new predicting method and health guidance for the progression of subclinical atherosclerosis using new lifestyle-related serum markers.

Research Project

Project/Area Number 22500663
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionOsaka University

Principal Investigator

NISHIDA Makoto  大阪大学, 保健センター, 准教授 (00379273)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords動脈硬化 / 危険因子 / 生活習慣 / 酸化ストレス / アポ蛋白 / 特定健診 / タバコ
Research Abstract

New serum markers which may indicate carotid atherosclerosis were evaluated with life-style in annual health checkup. ApoB48, a marker for lipids absorbed from intestine, did not correlate with atherosclerosis in all subjects, but significantly correlated in non-obese subjects. It shows apoB48 can be an useful marker detecting atherosclerosis in non-obese subjects. Other new markers including oxidative stress did not associate with progression of atherosclerosis, but with risk factors. Notably, smoking significantly associated progression of atherosclerosis even in a short period. It emphasizes the importance to stop smoking early.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop.2013

    • Author(s)
      Murakami M, Harada M, Kamimura D
    • Journal Title

      Cell Reports

      Volume: 3 Issue: 3 Pages: 946-59

    • DOI

      10.1016/j.celrep.2013.01.028

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smoking Promotes Subclinical Atherosclerosis in Apparently Healthy Men2012

    • Author(s)
      Sanada S, Nishida M, 他4名
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 12 Pages: 2884-2891

    • DOI

      10.1253/circj.CJ-11-1506

    • NAID

      10031126062

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low serum free testosterone level is associated with carotid intima-media thickness in middle-aged Japanese men2012

    • Author(s)
      Tsujimura A, Nishida M, 他11名
    • Journal Title

      Endocrine Journal

      Volume: 59 Issue: 9 Pages: 809-815

    • DOI

      10.1507/endocrj.EJ12-0060

    • NAID

      10031123124

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported Sleep Duration and Prediction of Proteinuria: A Retrospective Cohort Study.2012

    • Author(s)
      Yamamoto R, Nishida M, 他10名
    • Journal Title

      Am J Kidney Dis

      Volume: 59(3) Issue: 3 Pages: 343-55

    • DOI

      10.1053/j.ajkd.2011.08.032

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 大阪大学における学生喫煙率の推移と課題2012

    • Author(s)
      林 ルミ 西田 誠 他
    • Organizer
      第50回全国大学保健管理研究集会
    • Place of Presentation
      兵庫県
    • Year and Date
      2012-10-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 48 level is associated with subclinical atherosclerosis in non-obese men2012

    • Author(s)
      Makoto Nishida, et al.
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      Sydney Convention and Exhibition Centre,オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Serum apolipoprotein B-48 level is associated with subclinical atheroscle rosis in non-obese men2012

    • Author(s)
      Makoto Nishida, et al
    • Organizer
      XVI International Symposium on Atherosclerosis
    • Place of Presentation
      Sydney Convention and Exhibition Centre,シドニー,オーストラリア
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevention of Subclinical Athero- sclerosis: Search for Gender-specific Risk Factors and Salutary Interventions Against its Progression2012

    • Author(s)
      Shoji Sanada, Makoto Nishida, et al.
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      日マリンメッセ福岡 福岡県
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevention of Subclinical Atherosclerosis : Search for Gender-specific Risk Factors and Salutary Interventions Against its Progression2012

    • Author(s)
      Shoji Sanada, Makoto Nishida, et al
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      マリンメッセ福岡(福岡県)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serum Apolipoprotein B-48 Level Is Associated with Subclinical Athero- sclerosis in Non-obese Men2011

    • Author(s)
      Makoto Nishida, et al.
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌 北海道
    • Year and Date
      2011-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Serum Apolipoprotein B-48 Level Is Associated with Subclinical Atheros clerosis in Non-obese Men2011

    • Author(s)
      Makoto Nishida, et al
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Serum Apolipoprotein B-48 Level, But Not Remnant-like Particle Cholesterol Level, is Associated with Subclinical Atherosclerosis in Non-obese Men2011

    • Author(s)
      西田誠 他
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-03-20
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Oxidative Stress Predicts Worsening of Metabolic Risk Factors Independent of Adiposity2011

    • Author(s)
      西田誠 他
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-03-19
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 大阪大学における学生喫煙率の推移と課題

    • Author(s)
      林 ルミ 宮川理沙 西田 誠 熊谷一代 村井教子 川村淳子 大濱 透 真田昌爾 杉田義郎 守山敏樹 瀧原圭子
    • Organizer
      第50回全国大学保健管理研究集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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