| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Several epidemiological data suggest the deleterious influence of postprandial hemodynamic changes, including heart rate, blood pressure and cardiac autonomic activity. Improving the knowledge of such hemodynamicchanges should lead to advise diet modifications and to offer treatments able to limitmeal-induced deleterious hemodynamic consequences. The purpose of the investigation was threefold:
(1) to clarify the effect of meal amount on postprandial hemodynamic changes
(2) to compare the difference of postprandial hemodynamic changes at different dinner times of the day
(3) to compare postprandial hemodynamic changes in diabetics with those of healthy persons. The increase in insulin after nutrient intake was associated with postprandial hemodynamic changes and meal amount might play the important role on postprandial hemodynamic changes. Nocturnal eating (at 11pm) affected the rhythm of heart rate and cardiac autonomic activity during night resulting the high blood pressure in the morning. In patients with diabetes mellitus in the relatively early stage, postprandial decrease in central blood pressure as well as in brachial blood pressurewas observed.
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