| Project/Area Number |
22500665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAYAMA Fusako 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10236367)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Shigeru 岡山大学, 大学院・医歯薬学総合研究科, 特命教授, 名誉教授 (20033201)
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| Research Collaborator |
SUGIMOTO Shiho 岡山大学, 大学院・医歯薬学総合研究科, 博士前期課程・大学院生
MANKURA Mitsumasa 池田糖化工業株式会社, 理事
SATO Fumi 池田糖化工業株式会社, 研究室, 研究員
TOYODA Hiroshi 岡山協立病院, 病理部, 部長
WATANABE Ritsuko 岡山協立病院, 病理部, 主任
OKADA Shigeru 岡山大学, 大学院・医歯薬学総合研究科, 特命教授, 名誉教授
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NASH / 低酸素 / エネルギー代謝 / ミトコンドリア / 酸化ストレス / 炎症 / 鉄 / n-3 PUFA / 低酸素ストレス / DNA / EPA / コレステロール / 膜流動性 / 非アルコール性脂肪性肝炎 / ラジカル / 酸素欠乏 |
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| Research Abstract |
This study showed that DHA cholesteryl ester and EPA one were useful industrially, as both exerted higher effects to retard the NASH progress approximately 10 times than the respective ethyl ester. By evaluation system to reproduce NASH aggravation by choline deficient high fat diets and besides recurrent intermittent oxygen deficiency stress, it was exhibited that the efficacies resulted from relieving the decreased erythrocyte deformability and the persistent oxidative stress-inflammation.
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