Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease.

• Project/Area Number: 22500668
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Oita University
• Principal Investigator: YUFU Kunio 大分大学, 医学部, 助教 (00437930)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 心臓自律神経 / 魚油 / baroreflex sensitivity / Eicosapentaenoic acid / 心血管イベント / MACE / 自律神経 / N-3 Polyunsaturated Fatty Acids / Heart Rate Variability / autonomic function / 性差 / 2型糖尿病 / maior adverse cardiac and cerebrovascular events / 自律神経機能

Research Abstract

(1)BRS value could predict cardio- and cerebrovascular events in patients with type 2 diabetes. Therapeutic preventive strategies targeting the improvement of BRS should be considered in this population. (2)Depressed BRS value could predict cardiac cerebrovascular events especially in female patients with type 2 diabetes. Once diabetic, a female who developed an impaired BRS had a worse prognosis than similar male. Intensive management and/or therapy might be needed in this population. (3)Dietary EPA supplementation might increase serum levels of EPA and BRS value in patients with coronary artery disease. These effects might be one of reason why EPA had been associated with a reduced incidence of adverse cardiovascular events in patients with coronary artery disease.

Research Products

• [Journal Article] 糖尿病と心臓自律神経障害 (2013)
  • Author(s): 油布邦夫
  • Journal Title: 月刊糖尿病 糖尿病と心疾患 -基礎と臨床- Pages: 65-71
• [Journal Article] 糖尿病と心疾患 (2013)
  • Author(s): 油布邦夫
  • Journal Title: 糖尿病と心臓自律神経障害、月刊糖尿病 Volume: 5 Pages: 65-71
• [Journal Article] Gender difference in baroreflex sensitivity to predict cardiac and cerebrovascular events in type 2 diabetic patients (2011)
  • Author(s): Yufu K, Takahashi N, Okada N, Wakisaka O, Shinohara T, Nakagawa M, Hara M, Yoshimatsu H, Saikawa T
  • Journal Title: Circ J Volume: 75(6) Pages: 1418-1423
  • NAID: 10028148974
• [Journal Article] Gender difference in baroreflex sensitivity to predict cardiac and cerebrovasular events in type 2 diabetic patients (2011)
  • Author(s): Yufu K, Takahashi N, Okada N, Wakisaka O, Shinohara T, Hara M, Nakagawa M, Saikawa T
  • Journal Title: Circulation J Volume: 75 Pages: 1418-1423
  • Peer Reviewed
• [Journal Article] Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease (2010)
  • Author(s): Okada N,Takahashi N,Yufu K,Murozono Y,Wakisaka O,Shinohara T,Anan F, Nakagawa M,Hara M,Saikawa T,Yoshimatsu H
  • Journal Title: Circ J Volume: 74(7) Pages: 1379-1383
  • NAID: 10030695525
• [Journal Article] Baroreflex sensitivity predicts cardiovascular events in patients with type 2 diabetes mellitus without structural heart disease (2010)
  • Author(s): Okada N, Takahashi N, Yufu K, Murozono Y, Wakisaka O, Shinohara T, Anan F, Nakagawa M, Hara M, Saikawa T, Yoshimatsu H
  • Journal Title: Circulation J Volume: 74 Pages: 1379-1383
  • NAID: 10030695525
  • Peer Reviewed
• [Presentation] Tetsunori Saikawa.Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease (2013)
  • Author(s): Norihiro Okada, Naohiko Takahashi, Yuki Ebata, Tetsuji Shinohara, Kunio Yufu, Mikiko Nakagawa, Masahide Hara
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 神奈川
• [Presentation] Eicosapentaenoic acid supplementation on baroreflex sensitivity in patients with coronary artery disease. (2013)
  • Author(s): Norihiro Okada
  • Organizer: 第77回日本循環器学会学術集会 3.16-18,2012.
  • Place of Presentation: 神奈川
• [Presentation] Relationship between Serum Concentration of N-3 Polyunsaturated Fatty Acids and Heart Rate Variability Components (2012)
  • Author(s): Norihiro Okada, Naohiko Takahashi, Kunio Yufu, Tetsunori Saikawa
  • Organizer: 第76回日本循環器学会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] 犀川哲典心臓自律神経の2型糖尿病患者における脳心血管イベントの予測～性差について～ (2012)
  • Author(s): 油布邦夫、高橋尚彦、江畑有希、綾部礼佳、 岡田憲広、 篠原徹二 中川幹子、原政英
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] 心臓自律神経の2型糖尿病患者における脳心血管イベントの予測～性差について～ (2012)
  • Author(s): 油布邦夫
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡
• [Presentation] Cardiac 123I-MIBG scintigraphic findings predict cardiac and cerebrovascular events in type 2 diabetic patients without structural (2011)
  • Author(s): Yufu K, Takahashi N, Okada N, Wakisaka O, Shinohara T, Hara M, Nakagawa H, Saikawa T
  • Organizer: 第75回日本循環器学会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-03
• [Presentation] 心臓自律神経機能低下を伴う2型糖尿病患者の性差と脳心血管イベントの関連 (2010)
  • Author(s): 油布邦夫
  • Organizer: 第27回日本心電図学会・学術集会
  • Place of Presentation: 大分
  • Year and Date: 2010-10-08
• [Presentation] 犀川哲典心臓自律神経機能低下を伴う2 型糖尿病患者の性差と脳心血管イベントの関連 (2010)
  • Author(s): 油布邦夫、高橋尚彦、岡田憲広、脇坂収、中川幹子、原政英
  • Organizer: 第27回日本心電学会学術集会
  • Place of Presentation: 大分