Evaluation of vitamin C dynamics in the brain and its protection effect on neural cell system under the aging and oxidative stress load
| Project/Area Number |
22500672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Prefectural University of Hiroshima |
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Principal Investigator |
MUTO Norio 県立広島大学, 生命環境学部, 教授 (30112642)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 加齢 / 老化 / ビタミンC / 脳 / 神経細胞 / 栄養学 / 細胞・組織 / 免疫学 / 酸化ストレス障害 / ビタミンＣ / 脳神経疾患 |
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| Research Abstract |
By using ODS rats having no ability of vitamin C biosynthesis as a human model, the vitamin C dynamics in the brain and its role on the neural cells were evaluated. In the vitamin C-deficient group which mimics the physiological state of aging and oxidative stress, the levels of vitamin C in the serum and peripheral tissues significantly decreased, whereas that in the brain only tended to decrease. This indicates that vitamin C in the brain is retained by the specific mechanism distinct from that in other tissues. Vitamin C is proved to have both a promotion effect on the neural differentiation of PC12 cells and a protection effect on the oxidative stress -induced cell damage. Taken together, it is clearly demonstrated that vitamin C is an essential nutritional factor for regenerating and protecting the neural cells from the aging and oxidative stresses.
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Report
(4 results)
Research Products
(5 results)
