Effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis
| Project/Area Number |
22500674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kanagawa Institute of Technology (2012)
Josai University (2010-2011) |
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Principal Investigator |
CHIBA Hiroshige 神奈川工科大学, 応用バイオ科学部, 准教授 (30337779)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨粗鬆症 / フラボノイド / ヘスペリジン / 骨密度 / 骨吸収 / 骨組鬆症 |
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| Research Abstract |
The purpose of this study was to examine effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis. The concomitant intake of glucosylhesperidin and mevalonic acid had better effects in femur bone mineral density (BMD) and bone quality than glucosylhesperidin alone in ovariectomized mice. Hesperetin inhibited the osteoclast formation induced by RANKL in a dose-dependent manner in RAW 264 cells. These results indicate that hesperidin regulates the downstream signaling pathway of cholesterol synthesis, and the inhibition of bone resorption may contribute to the improvement bone metabolism.
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Report
(4 results)
Research Products
(22 results)
