Investigation for mechanisms of "resistance to lipid" in skeletal muscle
| Project/Area Number |
22500676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
KANAZAWA Akio 順天堂大学, 医学部, 准教授 (30407259)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Yoshifumi 順天堂大学, 医学部, 准教授 (80420834)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インスリン抵抗性 / 骨格筋細胞内脂質 |
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| Research Abstract |
The accumulation of intramyocellular lipid (IMCL) is regarded to be a cause of insulin resistance. On the other hand, increased accumulation of IMCL is also observed in insulin sensitive subjects (resistance to lipids). Thus, we aimed to clarify the mechanisms of the phenomenon. The IMCL levels were measured by 1H-magnetic resonance spectroscopy (MRS) and peripheral insulin sensitivity (GIR) was evaluated by clamp study. Muscle biopsy sample was obtained from vastus lateralis. Resistance to lipids is associated with increased expression level of lipid oxidation and uptake genes in skeletal muscle. These gene expressions may intermediate IMCL accumulation and insulin sensitivity.
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Report
(4 results)
Research Products
(6 results)
