| Project/Area Number |
22500678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
MURASE Norio 東京医科大学, 医学部, 講師 (10317894)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUMURA Toshihito 東京医科大学, 医学部, 教授 (80214352)
KIME Ryotaro 東京医科大学, 医学部, 講師 (90366120)
SHIGEMATSU Hiroshi 東京医科大学, 医学部, 教授 (40134556)
SHIMOMURA Kohsuke 東京医科大学, 医学部, 助教 (20453714)
WATANABE Yoshiko 東京医科大学, 医学部, 助教 (20366165)
OSADA Takuya 東京医科大学, 医学部, 講師 (60297281)
KOIZUMI Nobusato 東京医科大学, 医学部, 講師 (00328212)
NISHIBE Toshiya 東京医科大学, 医学部, 教授 (10261306)
OGINO Hitoshi 東京医科大学, 医学部, 教授 (60393237)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 閉塞性動脈硬化症 / 末梢動脈閉塞性疾患 / 運動療法 / 近赤外線分光法 / 筋酸素動態 / 最大歩行距離 / 自転車エルゴメータ / 無酸素性作業閾値 |
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| Research Abstract |
The purpose of this study was to establish the evaluation index of exercise therapyfor patients with peripheral arterial disease (PAD). The exercise therapy was conducted by using a bicycle ergometer at the intensity of the anoxic threshold (AT) provided by cardiopulmonary exercise tests (CPX) for three months. After considering maximum walkingdistance (MWD) and the relations of various indexes, the relationship between the improvement ratio of MWD before and after exercise therapy and that of recovery time (T1/2)of oxygen saturation followed by CPX in gastrocnemius muscle was significantly correlated. These results suggest that improvement of the muscle oxidative capacity in the gastrocnemius muscle contributed to improvement of walking ability, and it is thought to be an effective evaluation index.
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