| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To examine the effects of eccentric exercise (downhill walking) on the decline of muscular function with age, animals (rats)performed low intensity downhill walking for 2 years. As a result, the exercise reduced mitochondrial oxidative stress, which has been shown to have a negative impact on muscular function, and slowed the decline in muscular metabolism. Particularly, the effect of the exercise on the development of oxidative stress with age was clear in fast-twitch muscle. These results suggest that eccentric exercise can help to prevent a decline in muscular function with age.
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