Examination of the effect of eccentric exercise on fast-twitch muscle fiber metabolism over a lifespan
| Project/Area Number |
22500679
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 加齢 / 老化 / アンチエイジング / 酸化ストレス / ラット / ミトコンドリア / 骨格筋 / ミトコンドリア脱共役蛋白質 / ミトコンドリアDNA / DNA損傷 |
|---|
| Research Abstract |
To examine the effects of eccentric exercise (downhill walking) on the decline of muscular function with age, animals (rats)performed low intensity downhill walking for 2 years. As a result, the exercise reduced mitochondrial oxidative stress, which has been shown to have a negative impact on muscular function, and slowed the decline in muscular metabolism. Particularly, the effect of the exercise on the development of oxidative stress with age was clear in fast-twitch muscle. These results suggest that eccentric exercise can help to prevent a decline in muscular function with age.
|
Report
(4 results)
Research Products
(7 results)
